Primary and compensatory roles for RB family members at cell cycle gene promoters that are deacetylated and downregulated in doxorubicin-induced senescence of breast cancer cells.
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The transcription factor p53: not a repressor, solely an activatorPhysical and functional interaction between PML and TBX2 in the establishment of cellular senescenceTherapeutic targeting of replicative immortalityp53-mediated senescence impairs the apoptotic response to chemotherapy and clinical outcome in breast cancer.The p53-p21-DREAM-CDE/CHR pathway regulates G2/M cell cycle genesReduced expression of the retinoblastoma protein shows that the related signaling pathway is essential for mediating the antineoplastic activity of erufosineIscador Qu inhibits doxorubicin-induced senescence of MCF7 cellsDifferential patterns of allelic loss in estrogen receptor-positive infiltrating lobular and ductal breast cancer.Pro-proliferative FoxM1 is a target of p53-mediated repression.DEC1, a basic helix-loop-helix transcription factor and a novel target gene of the p53 family, mediates p53-dependent premature senescence.Tissue-specific and age-dependent effects of global Mdm2 lossInduction of cellular senescence by doxorubicin is associated with upregulated miR-375 and induction of autophagy in K562 cellsRestoring expression of wild-type p53 suppresses tumor growth but does not cause tumor regression in mice with a p53 missense mutation.Human papillomavirus E7 repression in cervical carcinoma cells initiates a transcriptional cascade driven by the retinoblastoma family, resulting in senescence.Butyrate mediates decrease of histone acetylation centered on transcription start sites and down-regulation of associated genesThe specific role of pRb in p16 (INK4A) -mediated arrest of normal and malignant human breast cellsCircadian Rhythms and Breast Cancer: The Role of Per2 in Doxorubicin-Induced Cell DeathThe p53-Mdm2 feedback loop protects against DNA damage by inhibiting p53 activity but is dispensable for p53 stability, development, and longevityRegulation of tissue- and stimulus-specific cell fate decisions by p53 in vivo.One function--multiple mechanisms: the manifold activities of p53 as a transcriptional repressor.The switch from pRb/p105 to Rb2/p130 in DNA damage and cellular senescence.Compensation: a contemporary regulatory machinery in cardiovascular diseases?Emerging roles of RB family: new defense mechanisms against tumor progression.Senescence regulation by the p53 protein familyGenetic compensation: A phenomenon in search of mechanisms.Teng-Long-Bu-Zhong-Tang induces p21-dependent cell senescence in colorectal carcinoma LS174T cells via histone acetylation.Census and evaluation of p53 target genes.The Regulation of Cellular Functions by the p53 Protein: Cellular Senescence.Expression of cyclin A, B1 and D1 after induction of cell cycle arrest in the Jurkat cell line exposed to doxorubicin.CREG1 enhances p16(INK4a) -induced cellular senescence.BMP4-Smad signaling pathway mediates adriamycin-induced premature senescence in lung cancer cellsDistinct roles for p107 and p130 in Rb-independent cellular senescence.Misidentified Human Gene Functions with Mouse Models: The Case of the Retinoblastoma Gene Family in Senescence.MRG15 activates the cdc2 promoter via histone acetylation in human cells.Contrasting effects of an Mdm2 functional polymorphism on tumor phenotypes.A decrease in cyclin B1 levels leads to polyploidization in DNA damage-induced senescence.Evaluation of the Neuroprotective Effect of Sirt3 in Experimental Stroke.Identification of a pyridine derivative inducing senescence in ovarian cancer cell lines via P21 activation.Cell cycle transcription control: DREAM/MuvB and RB-E2F complexes.Silencing of RB1 but not of RB2/P130 induces cellular senescence and impairs the differentiation potential of human mesenchymal stem cells.
P2860
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P2860
Primary and compensatory roles for RB family members at cell cycle gene promoters that are deacetylated and downregulated in doxorubicin-induced senescence of breast cancer cells.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Primary and compensatory roles ...... scence of breast cancer cells.
@en
Primary and compensatory roles ...... scence of breast cancer cells.
@nl
type
label
Primary and compensatory roles ...... scence of breast cancer cells.
@en
Primary and compensatory roles ...... scence of breast cancer cells.
@nl
prefLabel
Primary and compensatory roles ...... scence of breast cancer cells.
@en
Primary and compensatory roles ...... scence of breast cancer cells.
@nl
P2860
P1476
Primary and compensatory roles ...... scence of breast cancer cells.
@en
P2093
Olivia M Pereira-Smith
P2860
P304
P356
10.1128/MCB.26.7.2501-2510.2006
P407
P577
2006-04-01T00:00:00Z