Blockade of the Bcr-Abl kinase activity induces apoptosis of chronic myelogenous leukemia cells by suppressing signal transducer and activator of transcription 5-dependent expression of Bcl-xL
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Mast cell homeostasis and the JAK-STAT pathwayGATA-1 and Gfi-1B interplay to regulate Bcl-xL transcriptionInterleukin-15 prevents mouse mast cell apoptosis through STAT6-mediated Bcl-xL expressionInhibitory effect of c-Myc on p53-induced apoptosis in leukemia cells. Microarray analysis reveals defective induction of p53 target genes and upregulation of chaperone genesTargeting NF-kappaB in hematologic malignanciesNuclear factor kappaB-dependent gene expression profiling of Hodgkin's disease tumor cells, pathogenetic significance, and link to constitutive signal transducer and activator of transcription 5a activityLactogens protect rodent and human beta cells against glucolipotoxicity-induced cell death through Janus kinase-2 (JAK2)/signal transducer and activator of transcription-5 (STAT5) signallingThe Src family kinase Hck couples BCR/ABL to STAT5 activation in myeloid leukemia cells.Progressive changes in the leukemogenic signaling in BCR/ABL-transformed cells.A novel role for signal transducer and activator of transcription 5b (STAT5b) in beta1-integrin-mediated human breast cancer cell migration.The BCL2 inhibitor ABT-199 significantly enhances imatinib-induced cell death in chronic myeloid leukemia progenitorsSynergy between proteasome inhibitors and imatinib mesylate in chronic myeloid leukemia.STAT5 regulation of BCL10 parallels constitutive NFkappaB activation in lymphoid tumor cells.CM363, a novel naphthoquinone derivative which acts as multikinase modulator and overcomes imatinib resistance in chronic myelogenous leukemiaMolecular characterization of c-Abl/c-Src kinase inhibitors targeted against murine tumour progenitor cells that express stem cell markers.Bcr/Abl interferes with the Fanconi anemia/BRCA pathway: implications in the chromosomal instability of chronic myeloid leukemia cells.Linkage between STAT regulation and Epstein-Barr virus gene expression in tumors.Proliferation-attenuating and apoptosis-inducing effects of tryptanthrin on human chronic myeloid leukemia K562 cell line in vitroJak2 is involved in c-Myc induction by Bcr-Abl.TET2 mutations are associated with specific 5-methylcytosine and 5-hydroxymethylcytosine profiles in patients with chronic myelomonocytic leukemia.Transforming and tumorigenic activity of JAK2 by fusion to BCR: molecular mechanisms of action of a novel BCR-JAK2 tyrosine-kinase.Interferon-alpha combined with cytarabine in chronic myelogenous leukemia - clinical benefits.Fusion tyrosine kinases induce drug resistance by stimulation of homology-dependent recombination repair, prolongation of G(2)/M phase, and protection from apoptosis.Global proteome quantification for discovering imatinib-induced perturbation of multiple biological pathways in K562 human chronic myeloid leukemia cellsSTAT proteins: novel molecular targets for cancer drug discovery.Two clinical phenotypes in polycythemia vera.A critical role of CDKN3 in Bcr-Abl-mediated tumorigenesisTargeting apoptosis in cancer chemotherapy.BCR-ABL as a target for novel therapeutic interventions.BCR/ABL regulates response to DNA damage: the role in resistance to genotoxic treatment and in genomic instability.Imatinib spells BAD news for Bcr/abl-positive leukemiasBim and Bad mediate imatinib-induced killing of Bcr/Abl+ leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic.High affinity molecules disrupting GRB2 protein complexes as a therapeutic strategy for chronic myelogenous leukaemia.Resveratrol induces apoptosis of human chronic myelogenous leukemia cells in vitro through p38 and JNK-regulated H2AX phosphorylation.Chronic myelogenous leukemia as a paradigm of early cancer and possible curative strategies.HS-543 induces apoptosis of Imatinib-resistant chronic myelogenous leukemia with T315I mutation.Structure-Based Screen Identifies a Potent Small Molecule Inhibitor of Stat5a/b with Therapeutic Potential for Prostate Cancer and Chronic Myeloid Leukemia.Apoptosis as a tool for therapeutic agents in haematological diseases.Expression of angiogenic factors in chronic myeloid leukaemia: role of the bcr/abl oncogene, biochemical mechanisms, and potential clinical implications.Dietary compounds as potent inhibitors of the signal transducers and activators of transcription (STAT) 3 regulatory network.
P2860
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P2860
Blockade of the Bcr-Abl kinase activity induces apoptosis of chronic myelogenous leukemia cells by suppressing signal transducer and activator of transcription 5-dependent expression of Bcl-xL
description
2000 nî lūn-bûn
@nan
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
2000年论文
@zh
2000年论文
@zh-cn
name
Blockade of the Bcr-Abl kinase ...... dependent expression of Bcl-xL
@en
Blockade of the Bcr-Abl kinase ...... dependent expression of Bcl-xL
@nl
type
label
Blockade of the Bcr-Abl kinase ...... dependent expression of Bcl-xL
@en
Blockade of the Bcr-Abl kinase ...... dependent expression of Bcl-xL
@nl
prefLabel
Blockade of the Bcr-Abl kinase ...... dependent expression of Bcl-xL
@en
Blockade of the Bcr-Abl kinase ...... dependent expression of Bcl-xL
@nl
P2093
P2860
P356
P1476
Blockade of the Bcr-Abl kinase ...... dependent expression of Bcl-xL
@en
P2093
E J Andreu
J L Fernandez-Luna
P2860
P304
P356
10.1084/JEM.191.6.977
P407
P577
2000-03-01T00:00:00Z