Histone modification-dependent and -independent pathways for recruitment of checkpoint protein Crb2 to double-strand breaks. - Wikidata - wikimedia - TriplyDB

Histone modification-dependent and -independent pathways for recruitment of checkpoint protein Crb2 to double-strand breaks.

Histone modification-dependent and -independent pathways for recruitment of checkpoint protein Crb2 to double-strand breaks.

http://www.wikidata.org/entity/Q42150641

about

Nucleolar protein Spindlin1 recognizes H3K4 methylation and stimulates the expression of rRNA genes A polycomb group protein, PHF1, is involved in the response to DNA double-strand breaks in human cell Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair Structural and functional analysis of the Crb2-BRCT2 domain reveals distinct roles in checkpoint signaling and DNA damage repair γH2A binds Brc1 to maintain genome integrity during S-phase Phosphorylation-Dependent Assembly and Coordination of the DNA Damage Checkpoint Apparatus by Rad4TopBP1 Crystal structures of the human histone H4K20 methyltransferases SUV420H1 and SUV420H2 Rad9 BRCT domain interaction with phosphorylated H2AX regulates the G1 checkpoint in budding yeast.The checkpoint Saccharomyces cerevisiae Rad9 protein contains a tandem tudor domain that recognizes DNA Phosphorylation of the budding yeast 9-1-1 complex is required for Dpb11 function in the full activation of the UV-induced DNA damage checkpoint.Dpb11 coordinates Mec1 kinase activation with cell cycle-regulated Rad9 recruitment A chromatin-wide transition to H4K20 monomethylation impairs genome integrity and programmed DNA rearrangements in the mouse Telomeres avoid end detection by severing the checkpoint signal transduction pathway MMSET regulates histone H4K20 methylation and 53BP1 accumulation at DNA damage sites Sensing of replication stress and Mec1 activation act through two independent pathways involving the 9-1-1 complex and DNA polymerase ε Phosphorylation-dependent interactions between Crb2 and Chk1 are essential for DNA damage checkpoint Mdb1, a fission yeast homolog of human MDC1, modulates DNA damage response and mitotic spindle function Regulation of the DNA damage response and gene expression by the Dot1L histone methyltransferase and the 53Bp1 tumour suppressor Ctp1 is a cell-cycle-regulated protein that functions with Mre11 complex to control double-strand break repair by homologous recombination Evolution of SET-domain protein families in the unicellular and multicellular Ascomycota fungi.Preserving Yeast Genetic Heritage through DNA Damage Checkpoint Regulation and Telomere Maintenance.Mre11 nuclease activity and Ctp1 regulate Chk1 activation by Rad3ATR and Tel1ATM checkpoint kinases at double-strand breaks.Colocalization of sensors is sufficient to activate the DNA damage checkpoint in the absence of damage Rad3 decorates critical chromosomal domains with gammaH2A to protect genome integrity during S-Phase in fission yeast.Release of Ku and MRN from DNA ends by Mre11 nuclease activity and Ctp1 is required for homologous recombination repair of double-strand breaks.Dynamics of Rad9 chromatin binding and checkpoint function are mediated by its dimerization and are cell cycle-regulated by CDK1 activity A role for nuclear envelope-bridging complexes in homology-directed repair.Requirement for the phospho-H2AX binding module of Crb2 in double-strand break targeting and checkpoint activation TopBP1 functions with 53BP1 in the G1 DNA damage checkpoint.The Rad4(TopBP1) ATR-activation domain functions in G1/S phase in a chromatin-dependent manner.Maintenance of the DNA-damage checkpoint requires DNA-damage-induced mediator protein oligomerization.Tying the loose ends together in DNA double strand break repair with 53BP1.Interplay between histone H3 lysine 56 deacetylation and chromatin modifiers in response to DNA damage.Genetic Interaction Landscape Reveals Critical Requirements for Schizosaccharomyces pombe Brc1 in DNA Damage Response Mutants Regulation by polycomb and trithorax group proteins in Arabidopsis.Histone H3 lysine 14 acetylation is required for activation of a DNA damage checkpoint in fission yeast.Critical Function of γH2A in S-Phase Dimerization Mediated by a Divergent Forkhead-associated Domain Is Essential for the DNA Damage and Spindle Functions of Fission Yeast Mdb1.CRL4(Wdr70) regulates H2B monoubiquitination and facilitates Exo1-dependent resection.A new method to efficiently induce a site-specific double-strand break in the fission yeast Schizosaccharomyces pombe.

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P2860

Histone modification-dependent and -independent pathways for recruitment of checkpoint protein Crb2 to double-strand breaks.

http://www.wikidata.org/entity/Q42150641

description

2006 nî lūn-bûn

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2006年の論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

@zh-tw

2006年论文

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2006年论文

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2006年论文

@zh-cn

name

Histone modification-dependent ...... Crb2 to double-strand breaks.

@en

Histone modification-dependent ...... Crb2 to double-strand breaks.

@nl

type

label

Histone modification-dependent ...... Crb2 to double-strand breaks.

@en

Histone modification-dependent ...... Crb2 to double-strand breaks.

@nl

prefLabel

Histone modification-dependent ...... Crb2 to double-strand breaks.

@en

Histone modification-dependent ...... Crb2 to double-strand breaks.

@nl

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Genes & Development

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Histone modification-dependent ...... n Crb2 to double-strand breaks

@en

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Li-Lin Du

http://www.w3.org/2001/XMLSchema#string

Paul Russell

http://www.w3.org/2001/XMLSchema#string

P2860

The BRCT domain is a phospho-protein binding domain

A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin

Replication protein A-mediated recruitment and activation of Rad17 complexes

Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes

A generic protein purification method for protein complex characterization and proteome exploration

INO80 and gamma-H2AX interaction links ATP-dependent chromatin remodeling to DNA damage repair.

The DNA damage checkpoint response requires histone H2B ubiquitination by Rad6-Bre1 and H3 methylation by Dot1.

Role of Dot1-dependent histone H3 methylation in G1 and S phase DNA damage checkpoint functions of Rad9.

Accumulation of checkpoint protein 53BP1 at DNA breaks involves its binding to phosphorylated histone H2AX

BRCT repeats as phosphopeptide-binding modules involved in protein targeting

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1583-1596

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scholarly article

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10.1101/GAD.1422606

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12

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20

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Toru M Nakamura

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2006-06-01T00:00:00Z

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7005813

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16778077

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1482479

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