Mature bovine articular cartilage contains abundant aggrecan that is C-terminally truncated at Ala719-Ala720, a site which is readily cleaved by m-calpain.
about
Chondroitin sulfate N-acetylgalactosaminyltransferase 1 is necessary for normal endochondral ossification and aggrecan metabolismSuppression of MMP activity in bovine cartilage explants cultures has little if any effect on the release of aggrecanase-derived aggrecan fragments.Chondrocytes and meniscal fibrochondrocytes differentially process aggrecan during de novo extracellular matrix assembly.Matrix metalloproteinases are not essential for aggrecan turnover during normal skeletal growth and development.Adult bone marrow stromal cell-based tissue-engineered aggrecan exhibits ultrastructure and nanomechanical properties superior to native cartilageProteases involved in cartilage matrix degradation in osteoarthritis.Blocking aggrecanase cleavage in the aggrecan interglobular domain abrogates cartilage erosion and promotes cartilage repairBacterial calpains and the evolution of the calpain (C2) family of peptidasesSelective and non-selective metalloproteinase inhibitors reduce IL-1-induced cartilage degradation and loss of mechanical properties.Characterization of proteoglycan production and processing by chondrocytes and BMSCs in tissue engineered constructsAnalysis of ADAMTS4 and MT4-MMP indicates that both are involved in aggrecanolysis in interleukin-1-treated bovine cartilage.Calpain is involved in C-terminal truncation of human aggrecan.Investigating ADAMTS-mediated aggrecanolysis in mouse cartilage.MMP proteolysis of the human extracellular matrix protein aggrecan is mainly a process of normal turnover.
P2860
Q28594403-49A09900-3482-49C7-90CC-837BD8E67676Q33519701-CD1637CE-C3A2-4542-B7D9-493217010C9BQ33606423-6D715F1E-8A0B-42BA-AAAF-52624602881CQ33724459-E1715E11-644E-455A-81E2-EF52269A4A09Q34289098-9F6DEFDC-5A1F-4888-9C48-72CDF7783958Q35560686-E47357DE-D4AA-4A87-8987-EB23C68DFF35Q35785741-6CFC4BD2-D9B8-4273-AE7B-4F392B8F1876Q36243398-A535E9AD-5568-4B8A-9E9C-39D03F29995AQ36688890-2CBF8CF7-6435-4421-B520-395B7C318811Q37020871-C11998D6-5E28-4757-8215-A5360F61F89BQ37408063-8CE86AB9-8646-4329-828D-7B35A7F95C67Q45728839-83AB6BB6-D697-4E1B-ADD3-8D0A96D96E52Q50280462-E547EECE-58AB-4D06-A5FF-570C9E4A89C1Q53164462-9F1ACF9C-6FF9-49CF-A472-74075CBCCA71
P2860
Mature bovine articular cartilage contains abundant aggrecan that is C-terminally truncated at Ala719-Ala720, a site which is readily cleaved by m-calpain.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
@zh
2004年學術文章
@zh-hant
name
Mature bovine articular cartil ...... readily cleaved by m-calpain.
@en
Mature bovine articular cartil ...... readily cleaved by m-calpain.
@nl
type
label
Mature bovine articular cartil ...... readily cleaved by m-calpain.
@en
Mature bovine articular cartil ...... readily cleaved by m-calpain.
@nl
prefLabel
Mature bovine articular cartil ...... readily cleaved by m-calpain.
@en
Mature bovine articular cartil ...... readily cleaved by m-calpain.
@nl
P2093
P2860
P356
P1433
P1476
Mature bovine articular cartil ...... readily cleaved by m-calpain.
@en
P2093
Atsushi Akaike
Hidefumi Oshita
John D Sandy
Katsuji Shimizu
Kiichi Suzuki
Tomohiro Sasaki
P2860
P304
P356
10.1042/BJ20040113
P407
P577
2004-08-01T00:00:00Z