Age-related changes in the content of the C-terminal region of aggrecan in human articular cartilage
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Sites of aggrecan cleavage by recombinant human aggrecanase-1 (ADAMTS-4)The age-related changes in cartilage and osteoarthritisProteoglycan aggrecan conducting T cell activation and apoptosis in a murine model of rheumatoid arthritisWhy is osteoarthritis an age-related disease?Age-related changes in the musculoskeletal system and the development of osteoarthritis.The C-type lectin of the aggrecan G3 domain activates complement.Assessment of the clinical significance of gelatinase activity in patients with juvenile idiopathic arthritis using quantitative protein substrate zymography.Biomechanical considerations in the pathogenesis of osteoarthritis of the knee.The role of aggrecan in normal and osteoarthritic cartilage.Mapping the differential distribution of proteoglycan core proteins in the adult human retina, choroid, and sclera.Age-related nanostructural and nanomechanical changes of individual human cartilage aggrecan monomers and their glycosaminoglycan side chains.Aging and osteoarthritis: the role of chondrocyte senescence and aging changes in the cartilage matrix.Aggrecan is degraded by matrix metalloproteinases in human arthritis. Evidence that matrix metalloproteinase and aggrecanase activities can be independent.Recombinant production of proteoglycans and their bioactive domains.Age-related changes in the composition, the molecular stoichiometry and the stability of proteoglycan aggregates extracted from human articular cartilage.Age-related changes in the structure of the keratan sulphate chains attached to fibromodulin isolated from articular cartilage.Proteoglycans and catabolic products of proteoglycans present in ligament.Phenotypic diversity of neoplastic chondrocytes and extracellular matrix gene expression in cartilaginous neoplasms.Mature bovine articular cartilage contains abundant aggrecan that is C-terminally truncated at Ala719-Ala720, a site which is readily cleaved by m-calpain.Induction of arthritis in SCID mice by T cells specific for the "shared epitope" sequence in the G3 domain of human cartilage proteoglycan.Conserved basic residues in the C-type lectin and short complement repeat domains of the G3 region of proteoglycans.Age-related changes in the synthesis of link protein and aggrecan in human articular cartilage: implications for aggregate stability.The intermediates of aggrecanase-dependent cleavage of aggrecan in rat chondrosarcoma cells treated with interleukin-1.Analysis of aggrecan in human knee cartilage and synovial fluid indicates that aggrecanase (ADAMTS) activity is responsible for the catabolic turnover and loss of whole aggrecan whereas other protease activity is required for C-terminal processing iUse of synovial fluid markers of cartilage synthesis and turnover to study effects of repeated intra-articular administration of methylprednisolone acetate on articular cartilage in vivo.The characterization of versican and its message in human articular cartilage and intervertebral disc.Evidence of a novel aggrecan-degrading activity in cartilage: Studies of mice deficient in both ADAMTS-4 and ADAMTS-5.Investigating the Postmortem Molecular Biology of Cartilage and its Potential Forensic Applications.MMP proteolysis of the human extracellular matrix protein aggrecan is mainly a process of normal turnover.Generation and novel distribution of matrix metalloproteinase-derived aggrecan fragments in porcine cartilage explants.The matrix proteins aggrecan and fibulin-1 play a key role in determining aortic stiffness.
P2860
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P2860
Age-related changes in the content of the C-terminal region of aggrecan in human articular cartilage
description
1996 nî lūn-bûn
@nan
1996 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
name
Age-related changes in the con ...... n in human articular cartilage
@ast
Age-related changes in the con ...... n in human articular cartilage
@en
Age-related changes in the con ...... n in human articular cartilage
@nl
type
label
Age-related changes in the con ...... n in human articular cartilage
@ast
Age-related changes in the con ...... n in human articular cartilage
@en
Age-related changes in the con ...... n in human articular cartilage
@nl
prefLabel
Age-related changes in the con ...... n in human articular cartilage
@ast
Age-related changes in the con ...... n in human articular cartilage
@en
Age-related changes in the con ...... n in human articular cartilage
@nl
P2093
P2860
P356
P1433
P1476
Age-related changes in the con ...... n in human articular cartilage
@en
P2093
C M Davidson
D H Vynios
M T Bayliss
P2860
P304
P356
10.1042/BJ3130933
P407
P478
313 ( Pt 3)
P577
1996-02-01T00:00:00Z