A four-disulphide-bridged toxin, with high affinity towards voltage-gated K+ channels, isolated from Heterometrus spinnifer (Scorpionidae) venom.
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Mechanisms of maurotoxin action on Shaker potassium channels.Chemical synthesis and 1H-NMR 3D structure determination of AgTx2-MTX chimera, a new potential blocker for Kv1.2 channel, derived from MTX and AgTx2 scorpion toxinsStructural and functional consequences of the presence of a fourth disulfide bridge in the scorpion short toxins: Solution structure of the potassium channel inhibitor HsTX1Solution structure of Pi4, a short four-disulfide-bridged scorpion toxin specific of potassium channelsParameters affecting in vitro oxidation/folding of maurotoxin, a four-disulphide-bridged scorpion toxinSolution structure of IsTX. A male scorpion toxin from Opisthacanthus madagascariensis (Ischnuridae).Disulfide bridge reorganization induced by proline mutations in maurotoxin.Evidence for a new class of scorpion toxins active against K+ channels.Venomics: unravelling the complexity of animal venoms with mass spectrometry.Distribution and kinetics of the Kv1.3-blocking peptide HsTX1[R14A] in experimental rats.Performance comparison of three trypsin columns used in liquid chromatography.Hg1, novel peptide inhibitor specific for Kv1.3 channels from first scorpion Kunitz-type potassium channel toxin family.Brownian dynamics simulations of the recognition of the scorpion toxin maurotoxin with the voltage-gated potassium ion channels.A potent and Kv1.3-selective analogue of the scorpion toxin HsTX1 as a potential therapeutic for autoimmune diseasesVm24, a natural immunosuppressive peptide, potently and selectively blocks Kv1.3 potassium channels of human T cells.K+ channel modulators for the treatment of neurological disorders and autoimmune diseasesElectrophysiological characterization of Ts6 and Ts7, K⁺ channel toxins isolated through an improved Tityus serrulatus venom purification procedure.Nanoanalysis of the arthropod neuro-toxinsProlonged immunomodulation in inflammatory arthritis using the selective Kv1.3 channel blocker HsTX1[R14A] and its PEGylated analog.Purification, molecular cloning and functional characterization of HelaTx1 (Heterometrus laoticus): the first member of a new κ-KTX subfamilyK+ channel types targeted by synthetic OSK1, a toxin from Orthochirus scrobiculosus scorpion venom.Evidence for domain-specific recognition of SK and Kv channels by MTX and HsTx1 scorpion toxins.The 'functional' dyad of scorpion toxin Pi1 is not itself a prerequisite for toxin binding to the voltage-gated Kv1.2 potassium channels.Genomic organization of three novel toxins from the scorpion Buthus martensi Karsch that are active on potassium channels.Hemitoxin, the first potassium channel toxin from the venom of the Iranian scorpion Hemiscorpius lepturus.A maurotoxin with constrained standard disulfide bridging: innovative strategy of chemical synthesis, pharmacology, and docking on K+ channels.Synthesis and characterization of Pi4, a scorpion toxin from Pandinus imperator that acts on K+ channels.Evolutionary trace analysis of scorpion toxins specific for K-channels.Genomic organization of three neurotoxins active on small conductance Ca2+-activated potassium channels from the scorpion Buthus martensi Karsch.Chemical synthesis and characterization of Pi1, a scorpion toxin from Pandinus imperator active on K+ channels.Maurotoxin and the Kv1.1 channel: voltage-dependent binding upon enantiomerization of the scorpion toxin disulfide bridge Cys31-Cys34.Maurotoxin versus Pi1/HsTx1 scorpion toxins. Toward new insights in the understanding of their distinct disulfide bridge patterns.The impact of the fourth disulfide bridge in scorpion toxins of the α-KTx6 subfamily
P2860
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P2860
A four-disulphide-bridged toxin, with high affinity towards voltage-gated K+ channels, isolated from Heterometrus spinnifer (Scorpionidae) venom.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
A four-disulphide-bridged toxi ...... pinnifer (Scorpionidae) venom.
@en
A four-disulphide-bridged toxi ...... pinnifer (Scorpionidae) venom.
@nl
type
label
A four-disulphide-bridged toxi ...... pinnifer (Scorpionidae) venom.
@en
A four-disulphide-bridged toxi ...... pinnifer (Scorpionidae) venom.
@nl
prefLabel
A four-disulphide-bridged toxi ...... pinnifer (Scorpionidae) venom.
@en
A four-disulphide-bridged toxi ...... pinnifer (Scorpionidae) venom.
@nl
P2093
P2860
P356
P1433
P1476
A four-disulphide-bridged toxi ...... pinnifer (Scorpionidae) venom.
@en
P2093
Ishiguro M
Martin-Eauclaire MF
Nakajima T
Romi-Lebrun R
P2860
P304
P356
10.1042/BJ3280321
P407
P478
328 ( Pt 1)
P577
1997-11-01T00:00:00Z