Replicon dynamics, dormant origin firing, and terminal fork integrity after double-strand break formation
about
The splicing-factor related protein SFPQ/PSF interacts with RAD51D and is necessary for homology-directed repair and sister chromatid cohesionFBH1 co-operates with MUS81 in inducing DNA double-strand breaks and cell death following replication stressATP-driven Rad50 conformations regulate DNA tethering, end resection, and ATM checkpoint signalingDifferences in the DNA replication of unicellular eukaryotes and metazoans: known unknownsReplication termination at eukaryotic chromosomes is mediated by Top2 and occurs at genomic loci containing pausing elementsThe role of the Fanconi anemia network in the response to DNA replication stress.To fuse or not to fuse: how do checkpoint and DNA repair proteins maintain telomeres?Initiation and completion of spontaneous mitotic recombination occur in different cell cycle phases.DNA-PK phosphorylation of RPA32 Ser4/Ser8 regulates replication stress checkpoint activation, fork restart, homologous recombination and mitotic catastrophe.More forks on the road to replication stress recoveryChromosome catastrophes involve replication mechanisms generating complex genomic rearrangementsEvaluating genome-scale approaches to eukaryotic DNA replication.Checkpoint genes and Exo1 regulate nearby inverted repeat fusions that form dicentric chromosomes in Saccharomyces cerevisiaeIncreased telomere fragility and fusions resulting from TRF1 deficiency lead to degenerative pathologies and increased cancer in miceMec1/ATR regulates the generation of single-stranded DNA that attenuates Tel1/ATM signaling at DNA ends.Error-free DNA damage tolerance and sister chromatid proximity during DNA replication rely on the PolĪ±/Primase/Ctf4 ComplexReplication fork integrity and intra-S phase checkpoint suppress gene amplification.Different nucleosomal architectures at early and late replicating origins in Saccharomyces cerevisiae.The DNA repair endonuclease Mus81 facilitates fast DNA replication in the absence of exogenous damageAberrant firing of replication origins potentially explains intragenic nonrecurrent rearrangements within genes, including the human DMD gene.The nuclear pore complex protein Elys is required for genome stability in mouse intestinal epithelial progenitor cells.Abundance of prereplicative complexes (Pre-RCs) facilitates recombinational repair under replication stress in fission yeastOntogeny of Unstable Chromosomes Generated by Telomere Error in Budding Yeast.DNA REPAIR. Mus81 and converging forks limit the mutagenicity of replication fork breakage.Novel connections between DNA replication, telomere homeostasis, and the DNA damage response revealed by a genome-wide screen for TEL1/ATM interactions in Saccharomyces cerevisiae.Quantitative, genome-wide analysis of eukaryotic replication initiation and terminationSaccharomyces cerevisiae as a Model to Study Replicative Senescence Triggered by Telomere Shortening.Impaired replication elongation in Tetrahymena mutants deficient in histone H3 Lys 27 monomethylation.ATR/Mec1 prevents lethal meiotic recombination initiation on partially replicated chromosomes in budding yeast.Stalled DNA Replication Forks at the Endogenous GAA Repeats Drive Repeat Expansion in Friedreich's Ataxia Cells.Telomere length regulation: coupling DNA end processing to feedback regulation of telomerase.Replicating damaged DNA in eukaryotes.Nucleolytic processing of aberrant replication intermediates by an Exo1-Dna2-Sae2 axis counteracts fork collapse-driven chromosome instability.The S-phase checkpoint: targeting the replication fork.Spatial regulation and organization of DNA replication within the nucleus.Polycomb proteins control proliferation and transformation independently of cell cycle checkpoints by regulating DNA replication.Impediments to replication fork movement: stabilisation, reactivation and genome instability.The DNA damage checkpoint response to replication stress: A Game of Forks.Replication-fork dynamics.Epigenetic landscape for initiation of DNA replication.
P2860
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P2860
Replicon dynamics, dormant origin firing, and terminal fork integrity after double-strand break formation
description
2009 nĆ® lÅ«n-bĆ»n
@nan
2009幓ć®č«ę
@ja
2009幓č«ę
@yue
2009幓č«ę
@zh-hant
2009幓č«ę
@zh-hk
2009幓č«ę
@zh-mo
2009幓č«ę
@zh-tw
2009幓č®ŗę
@wuu
2009幓č®ŗę
@zh
2009幓č®ŗę
@zh-cn
name
Replicon dynamics, dormant ori ...... double-strand break formation
@en
Replicon dynamics, dormant ori ...... double-strand break formation
@nl
type
label
Replicon dynamics, dormant ori ...... double-strand break formation
@en
Replicon dynamics, dormant ori ...... double-strand break formation
@nl
prefLabel
Replicon dynamics, dormant ori ...... double-strand break formation
@en
Replicon dynamics, dormant ori ...... double-strand break formation
@nl
P2860
P50
P1433
P1476
Replicon dynamics, dormant ori ...... double-strand break formation
@en
P2093
Simona Fiorani
Ylli Doksani
P2860
P304
P356
10.1016/J.CELL.2009.02.016
P407
P577
2009-04-09T00:00:00Z