A murine Mll-AF4 knock-in model results in lymphoid and myeloid deregulation and hematologic malignancy. - Wikidata - wikimedia - TriplyDB

A murine Mll-AF4 knock-in model results in lymphoid and myeloid deregulation and hematologic malignancy.

A murine Mll-AF4 knock-in model results in lymphoid and myeloid deregulation and hematologic malignancy.

http://www.wikidata.org/entity/Q42193771

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Revisiting the biology of infant t(4;11)/MLL-AF4+ B-cell acute lymphoblastic leukemia Animal models of leukemia: any closer to the real thing?Murine models of acute leukemia: important tools in current pediatric leukemia research.Two decades of leukemia oncoprotein epistasis: the MLL1 paradigm for epigenetic deregulation in leukemia.MLL gene rearrangements in infant leukemia vary with age at diagnosis and selected demographic factors: a Children's Oncology Group (COG) study.De Novo Assembly of the Donkey White Blood Cell Transcriptome and a Comparative Analysis of Phenotype-Associated Genes between Donkeys and Horses.Use of Genome Engineering to Create Patient Specific MLL Translocations in Primary Human Hematopoietic Stem and Progenitor Cells.MLL fusions: pathways to leukemia Dysregulation of the DNA Damage Response and KMT2A Rearrangement in Fetal Liver Hematopoietic Cells.Targeting DOT1L and HOX gene expression in MLL-rearranged leukemia and beyond A human ESC model for MLL-AF4 leukemic fusion gene reveals an impaired early hematopoietic-endothelial specification.Acute myeloid leukemia stem cells and CD33-targeted immunotherapy MLL leukemia induction by genome editing of human CD34+ hematopoietic cells.Challenges and strategies for generating therapeutic patient-specific hemangioblasts and hematopoietic stem cells from human pluripotent stem cells Prospective tracing of MLL-FRYL clone with low MEIS1 expression from emergence during neuroblastoma treatment to diagnosis of myelodysplastic syndrome RUNX1 is a key target in t(4;11) leukemias that contributes to gene activation through an AF4-MLL complex interaction.Malignant transformation initiated by Mll-AF9: gene dosage and critical target cells.Microenvironment determines lineage fate in a human model of MLL-AF9 leukemia.Frequencies and prognostic impact of RAS mutations in MLL-rearranged acute lymphoblastic leukemia in infants.H3K79 methylation profiles define murine and human MLL-AF4 leukemias.Deciphering KRAS and NRAS mutated clone dynamics in MLL-AF4 paediatric leukaemia by ultra deep sequencing analysis.Insights into the cellular origin and etiology of the infant pro-B acute lymphoblastic leukemia with MLL-AF4 rearrangement.Pathogenetic, Clinical, and Prognostic Features of Adult t(4;11)(q21;q23)/MLL-AF4 Positive B-Cell Acute Lymphoblastic Leukemia.Ras/Raf/MEK/ERK Pathway Activation in Childhood Acute Lymphoblastic Leukemia and Its Therapeutic Targeting Genetically engineered mouse models of human B-cell precursor leukemias.Molecular mechanisms of MLL-associated leukemia.Chemical exposure and infant leukaemia: development of an adverse outcome pathway (AOP) for aetiology and risk assessment research.Mll-AF4 Confers Enhanced Self-Renewal and Lymphoid Potential during a Restricted Window in Development.Mouse models of MLL leukemia: recapitulating the human disease Dysregulation of haematopoietic stem cell regulatory programs in acute myeloid leukaemia.Epigenetics and Cancer Stem Cells: Unleashing, Hijacking, and Restricting Cellular Plasticity.Prognostic significance of FLT3 mutational status and expression levels in MLL-AF4+ and MLL-germline acute lymphoblastic leukemia.Bimodal degradation of MLL by SCFSkp2 and APCCdc20 assures cell cycle execution: a critical regulatory circuit lost in leukemogenic MLL fusions.t(4;11) leukemias display addiction to MLL-AF4 but not to AF4-MLL Mixed-lineage-leukemia (MLL) fusion protein collaborates with Ras to induce acute leukemia through aberrant Hox expression and Raf activation.Ligand-independent FLT3 activation does not cooperate with MLL-AF4 to immortalize/transform cord blood CD34+ cells.The silent mutational landscape of infant MLL-AF4 pro-B acute lymphoblastic leukemia.Molecular processes involved in B cell acute lymphoblastic leukaemia.Complementary activities of DOT1L and Menin inhibitors in MLL-rearranged leukemia.Epigenetic dysregulation of leukaemic HOX code in MLL-rearranged leukaemia mouse model.

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P2860

A murine Mll-AF4 knock-in model results in lymphoid and myeloid deregulation and hematologic malignancy.

http://www.wikidata.org/entity/Q42193771

description

2006 nî lūn-bûn

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2006年の論文

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2006年学术文章

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2006年学术文章

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2006年學術文章

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2006年學術文章

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name

A murine Mll-AF4 knock-in mode ...... on and hematologic malignancy.

@en

A murine Mll-AF4 knock-in mode ...... on and hematologic malignancy.

@nl

type

label

A murine Mll-AF4 knock-in mode ...... on and hematologic malignancy.

@en

A murine Mll-AF4 knock-in mode ...... on and hematologic malignancy.

@nl

prefLabel

A murine Mll-AF4 knock-in mode ...... on and hematologic malignancy.

@en

A murine Mll-AF4 knock-in mode ...... on and hematologic malignancy.

@nl

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A murine Mll-AF4 knock-in mode ...... on and hematologic malignancy.

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Ashish Kumar

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John H Kersey

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Nicole Kirchhof

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Quanzhi Li

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Weili Chen

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Wendy A Hudson

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P2860

AF5q31, a newly identified AF4-related gene, is fused to MLL in infant acute lymphoblastic leukemia with ins(5;11)(q31;q13q23)

Acute mixed-lineage leukemia t(4;11)(q21;q23) generates an MLL-AF4 fusion product

LAF-4 encodes a lymphoid nuclear protein with transactivation potential that is homologous to AF-4, the gene fused to MLL in t(4;11) leukemias

Menin and MLL cooperatively regulate expression of cyclin-dependent kinase inhibitors

The MLL fusion gene, MLL-AF4, regulates cyclin-dependent kinase inhibitor CDKN1B (p27kip1) expression

Identification of a gene, MLL, that spans the breakpoint in 11q23 translocations associated with human leukemias

Hoxa9 and Meis1 are key targets for MLL-ENL-mediated cellular immortalization

Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell

Modulation of cell cycle by graded expression of MLL-AF4 fusion oncoprotein

Altered Hox expression and segmental identity in Mll-mutant mice

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10.1182/BLOOD-2005-08-3498

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7227016

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16551973

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1895483

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