A murine Mll-AF4 knock-in model results in lymphoid and myeloid deregulation and hematologic malignancy.
about
Revisiting the biology of infant t(4;11)/MLL-AF4+ B-cell acute lymphoblastic leukemiaAnimal models of leukemia: any closer to the real thing?Murine models of acute leukemia: important tools in current pediatric leukemia research.Two decades of leukemia oncoprotein epistasis: the MLL1 paradigm for epigenetic deregulation in leukemia.MLL gene rearrangements in infant leukemia vary with age at diagnosis and selected demographic factors: a Children's Oncology Group (COG) study.De Novo Assembly of the Donkey White Blood Cell Transcriptome and a Comparative Analysis of Phenotype-Associated Genes between Donkeys and Horses.Use of Genome Engineering to Create Patient Specific MLL Translocations in Primary Human Hematopoietic Stem and Progenitor Cells.MLL fusions: pathways to leukemiaDysregulation of the DNA Damage Response and KMT2A Rearrangement in Fetal Liver Hematopoietic Cells.Targeting DOT1L and HOX gene expression in MLL-rearranged leukemia and beyondA human ESC model for MLL-AF4 leukemic fusion gene reveals an impaired early hematopoietic-endothelial specification.Acute myeloid leukemia stem cells and CD33-targeted immunotherapyMLL leukemia induction by genome editing of human CD34+ hematopoietic cells.Challenges and strategies for generating therapeutic patient-specific hemangioblasts and hematopoietic stem cells from human pluripotent stem cellsProspective tracing of MLL-FRYL clone with low MEIS1 expression from emergence during neuroblastoma treatment to diagnosis of myelodysplastic syndromeRUNX1 is a key target in t(4;11) leukemias that contributes to gene activation through an AF4-MLL complex interaction.Malignant transformation initiated by Mll-AF9: gene dosage and critical target cells.Microenvironment determines lineage fate in a human model of MLL-AF9 leukemia.Frequencies and prognostic impact of RAS mutations in MLL-rearranged acute lymphoblastic leukemia in infants.H3K79 methylation profiles define murine and human MLL-AF4 leukemias.Deciphering KRAS and NRAS mutated clone dynamics in MLL-AF4 paediatric leukaemia by ultra deep sequencing analysis.Insights into the cellular origin and etiology of the infant pro-B acute lymphoblastic leukemia with MLL-AF4 rearrangement.Pathogenetic, Clinical, and Prognostic Features of Adult t(4;11)(q21;q23)/MLL-AF4 Positive B-Cell Acute Lymphoblastic Leukemia.Ras/Raf/MEK/ERK Pathway Activation in Childhood Acute Lymphoblastic Leukemia and Its Therapeutic TargetingGenetically engineered mouse models of human B-cell precursor leukemias.Molecular mechanisms of MLL-associated leukemia.Chemical exposure and infant leukaemia: development of an adverse outcome pathway (AOP) for aetiology and risk assessment research.Mll-AF4 Confers Enhanced Self-Renewal and Lymphoid Potential during a Restricted Window in Development.Mouse models of MLL leukemia: recapitulating the human diseaseDysregulation of haematopoietic stem cell regulatory programs in acute myeloid leukaemia.Epigenetics and Cancer Stem Cells: Unleashing, Hijacking, and Restricting Cellular Plasticity.Prognostic significance of FLT3 mutational status and expression levels in MLL-AF4+ and MLL-germline acute lymphoblastic leukemia.Bimodal degradation of MLL by SCFSkp2 and APCCdc20 assures cell cycle execution: a critical regulatory circuit lost in leukemogenic MLL fusions.t(4;11) leukemias display addiction to MLL-AF4 but not to AF4-MLLMixed-lineage-leukemia (MLL) fusion protein collaborates with Ras to induce acute leukemia through aberrant Hox expression and Raf activation.Ligand-independent FLT3 activation does not cooperate with MLL-AF4 to immortalize/transform cord blood CD34+ cells.The silent mutational landscape of infant MLL-AF4 pro-B acute lymphoblastic leukemia.Molecular processes involved in B cell acute lymphoblastic leukaemia.Complementary activities of DOT1L and Menin inhibitors in MLL-rearranged leukemia.Epigenetic dysregulation of leukaemic HOX code in MLL-rearranged leukaemia mouse model.
P2860
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P2860
A murine Mll-AF4 knock-in model results in lymphoid and myeloid deregulation and hematologic malignancy.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
@yue
2006年學術文章
@zh
2006年學術文章
@zh-hant
name
A murine Mll-AF4 knock-in mode ...... on and hematologic malignancy.
@en
A murine Mll-AF4 knock-in mode ...... on and hematologic malignancy.
@nl
type
label
A murine Mll-AF4 knock-in mode ...... on and hematologic malignancy.
@en
A murine Mll-AF4 knock-in mode ...... on and hematologic malignancy.
@nl
prefLabel
A murine Mll-AF4 knock-in mode ...... on and hematologic malignancy.
@en
A murine Mll-AF4 knock-in mode ...... on and hematologic malignancy.
@nl
P2093
P2860
P1433
P1476
A murine Mll-AF4 knock-in mode ...... on and hematologic malignancy.
@en
P2093
Ashish Kumar
John H Kersey
Nicole Kirchhof
Quanzhi Li
Weili Chen
Wendy A Hudson
P2860
P304
P356
10.1182/BLOOD-2005-08-3498
P407
P577
2006-03-21T00:00:00Z