3'-substituted 2',3'-dideoxynucleoside analogues as potential anti-HIV (HTLV-III/LAV) agents. - Wikidata - wikimedia - TriplyDB

3'-substituted 2',3'-dideoxynucleoside analogues as potential anti-HIV (HTLV-III/LAV) agents.

3'-substituted 2',3'-dideoxynucleoside analogues as potential anti-HIV (HTLV-III/LAV) agents.

http://www.wikidata.org/entity/Q42216602

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Antiviral prodrugs - the development of successful prodrug strategies for antiviral chemotherapy Greatly enhanced inhibition of human immunodeficiency virus type 1 replication in CEM and HT4-6C cells by 3'-deoxythymidine diphosphate dimyristoylglycerol, a lipid prodrug of 3'-deoxythymidine Comparisons of anti-human immunodeficiency virus activities, cellular transport, and plasma and intracellular pharmacokinetics of 3'-fluoro-3'-deoxythymidine and 3'-azido-3'-deoxythymidine Comparison of in vitro biological properties and mouse toxicities of three thymidine analogs active against human immunodeficiency virus An antiviral target on reverse transcriptase of human immunodeficiency virus type 1 revealed by tetrahydroimidazo-[4,5,1-jk] [1,4]benzodiazepin-2 (1H)-one and -thione derivatives Pyridinone derivatives: specific human immunodeficiency virus type 1 reverse transcriptase inhibitors with antiviral activity Anti-human immunodeficiency virus type 1 activity and in vitro toxicity of 2'-deoxy-3'-thiacytidine (BCH-189), a novel heterocyclic nucleoside analog Structure-activity relationships of fluorinated nucleoside analogs and their synergistic effect in combination with phosphonoformate against human immunodeficiency virus type 1 New classes of fluorinated L-nucleosides; synthesis and antiviral activity Anti-human immunodeficiency virus activities of nucleosides and nucleotides: correlation with molecular electrostatic potential data.Structure of the anti-human immunodeficiency virus agent 3'-fluoro-3'-deoxythymidine and electronic charge calculations for 3'-deoxythymidines.Molecular modeling approach to understanding the mode of action of L-nucleosides as antiviral agents Probing the mechanistic consequences of 5-fluorine substitution on cytidine nucleotide analogue incorporation by HIV-1 reverse transcriptase.The synthesis of branched-chain 3'-C-cyanomethyl-2',3'-dideoxy sugar nucleosides of adenine as potential inhibitors of the human immunodeficiency virus Correlation of molecular conformation and activity of reverse transcriptase inhibitors.Fluorinated Nucleosides: Synthesis and Biological Implication In vitro bone marrow toxicity of nucleoside analogs against human immunodeficiency virus.Short synthesis and antiviral evaluation of C-fluoro-branched cyclopropyl nucleosides.Synthesis, solution conformation and anti-HIV activity of novel 3'-substituted-2',3'-dideoxy-5-hydroxymethyluridines and their 4,5-substituted analogues.Synthesis, in vitro anti-HIV activity, and biological stability of 5'-O-myristoyl analogue derivatives of 3'-fluoro-2',3'-dideoxythymidine (FLT) as potential bifunctional prodrugs of FLT.Nucleoside analogues previously found to be inactive against HIV may be activated by simple chemical phosphorylation.Certain phosphoramidate derivatives of dideoxy uridine (ddU) are active against HIV and successfully by-pass thymidine kinase.New 3'-deoxythymidines bearing a nucleophilic 3'-substituent.Synthesis of carbocyclic analogs of 2',3'-dideoxysangivamycin, 2',3'-dideoxytoyocamycin, and 2',3'-dideoxytriciribine.Synthesis of novel 8-substituted carbocyclic analogs of 2',3'-dideoxyadenosine with activity against hepatitis B virus.A facile synthetic method for 3'-alpha-fluoro-2',3'-dideoxyadenosine.Synthesis and antiviral evaluation of some 3'-fluoro bicyclic nucleoside analogues.Improved and reliable synthesis of 3'-azido-2',3'-dideoxyguanosine derivatives.Phosphoramidate protides of carbocyclic 2',3'-dideoxy-2',3'-didehydro-7-deazaadenosine with potent activity against HIV and HBV.The effect of a methyl or 2-fluoroethyl substituent at the N-3 position of thymidine, 3'-fluoro-3'-deoxythymidine and 1-beta-D-arabinosylthymine on their antiviral and cytostatic activity in cell culture.Antiviral research at the Rega Institute (KU leuven), now 50 years old.Application of solid-phase chemistry for the synthesis of 3'-fluoro-3'-deoxythymidine.Synthesis and Antiviral Activity of Novel Fluorinated 2′,3′‐Dideoxynucleosides Synthesis of New Thiazolidinone Nucleoside Analogues Synthesis and Structure of 2′,3′-Dideoxy-3′-fluoro-5-cyanouridine Synthesis of Nucleosides Fluorinated in the Sugar Moiety. The Application of Diethylaminosulfur Trifluoride to the Synthesis of Fluorinated Nucleosides Synthesis and Antifungal Activity of Arylthiocyanates Synthesis of 3′-fluoromethylthio-, 3′-fluoromethylsulfinyl- and 3′-fluoromethylsulfonyl-substituted 3′-deoxythymidine

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P2860

3'-substituted 2',3'-dideoxynucleoside analogues as potential anti-HIV (HTLV-III/LAV) agents.

http://www.wikidata.org/entity/Q42216602

description

1987 nî lūn-bûn

@nan

1987年の論文

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1987年論文

@yue

1987年論文

@zh-hant

1987年論文

@zh-hk

1987年論文

@zh-mo

1987年論文

@zh-tw

1987年论文

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1987年论文

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1987年论文

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name

3'-substituted 2',3'-dideoxynu ...... nti-HIV (HTLV-III/LAV) agents.

@en

3'-substituted 2',3'-dideoxynu ...... nti-HIV (HTLV-III/LAV) agents.

@nl

type

label

3'-substituted 2',3'-dideoxynu ...... nti-HIV (HTLV-III/LAV) agents.

@en

3'-substituted 2',3'-dideoxynu ...... nti-HIV (HTLV-III/LAV) agents.

@nl

prefLabel

3'-substituted 2',3'-dideoxynu ...... nti-HIV (HTLV-III/LAV) agents.

@en

3'-substituted 2',3'-dideoxynu ...... nti-HIV (HTLV-III/LAV) agents.

@nl

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Journal of Medicinal Chemistry

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3'-substituted 2',3'-dideoxynu ...... nti-HIV (HTLV-III/LAV) agents.

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Baba M

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Balzarini J

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Broder S

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De Clercq E

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Herdewijn P

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Pauwels R

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Vanderhaeghe H

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1270-1278

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10.1021/JM00391A003

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8

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30

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1987-08-01T00:00:00Z

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3497272

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