Synthetic FXR agonist GW4064 is a modulator of multiple G protein-coupled receptors
about
The M. tuberculosis HAD phosphatase (Rv3042c) interacts with host proteins and is inhibited by ClofazimineStructural Investigation for Optimization of Anthranilic Acid Derivatives as Partial FXR Agonists by in Silico Approaches.Implications of a peroxisome proliferator-activated receptor alpha (PPARα) ligand clofibrate in breast cancerThe role of bile acids in functional GI disorders.Chenodeoxycholic acid requires activation of EGFR, EPAC, and Ca2+ to stimulate CFTR-dependent Cl- secretion in human colonic T84 cells.Dihydroartemisinin restricts hepatic stellate cell contraction via an FXR-S1PR2-dependent mechanism.SAR studies on FXR modulators led to the discovery of the first combined FXR antagonistic/TGR5 agonistic compound.Intracellular calcium signaling regulates autophagy via calcineurin-mediated TFEB dephosphorylation.A rapid administration of GW4064 inhibits the NLRP3 inflammasome activation independent of farnesoid X receptor agonism.Nonacidic Chemotype Possessing N-Acylated Piperidine Moiety as Potent Farnesoid X Receptor (FXR) Antagonists.
P2860
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P2860
Synthetic FXR agonist GW4064 is a modulator of multiple G protein-coupled receptors
description
2014 nî lūn-bûn
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2014年の論文
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2014年論文
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2014年論文
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2014年論文
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2014年論文
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2014年論文
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2014年论文
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2014年论文
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2014年论文
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name
Synthetic FXR agonist GW4064 is a modulator of multiple G protein-coupled receptors
@en
Synthetic FXR agonist GW4064 is a modulator of multiple G protein-coupled receptors
@nl
type
label
Synthetic FXR agonist GW4064 is a modulator of multiple G protein-coupled receptors
@en
Synthetic FXR agonist GW4064 is a modulator of multiple G protein-coupled receptors
@nl
prefLabel
Synthetic FXR agonist GW4064 is a modulator of multiple G protein-coupled receptors
@en
Synthetic FXR agonist GW4064 is a modulator of multiple G protein-coupled receptors
@nl
P2093
P2860
P50
P356
P1476
Synthetic FXR agonist GW4064 is a modulator of multiple G protein-coupled receptors
@en
P2093
Abhishek Kumar Singh
Amit Manhas
Anagha Gurjar
Arun Kumar Trivedi
Harish Kumar
Kumaravelu Jagavelu
Manisha Yadav
Mohammad Imran Siddiqi
Nidhi Singh
Prem Narayan Yadav
P2860
P304
P356
10.1210/ME.2013-1353
P577
2014-03-05T00:00:00Z