Molecular determinants of state-dependent block of Na+ channels by local anesthetics.
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Propranolol blocks cardiac and neuronal voltage-gated sodium channelsSodium channel molecular conformations and antiarrhythmic drug affinityRole of voltage-gated sodium, potassium and calcium channels in the development of cocaine-associated cardiac arrhythmiasConformational state-dependent anion binding in prestin: evidence for allosteric modulationThe pharmacology of cyclic nucleotide-gated channels: emerging from the darknessMolecular basis of ranolazine block of LQT-3 mutant sodium channels: evidence for site of actionMolecular analysis of the Na+ channel blocking actions of the novel class I anti-arrhythmic agent RSD 921Increased sensitivity to thermal pain and reduced subcutaneous lidocaine efficacy in redheadsState-dependent trapping of flecainide in the cardiac sodium channelMolecular targets for antiepileptic drug developmentLocal anesthetic resistance in a pregnant patient with lumbosacral plexopathy.The hitchhiker's guide to the voltage-gated sodium channel galaxyConotoxins That Could Provide Analgesia through Voltage Gated Sodium Channel InhibitionComputational Studies of Venom Peptides Targeting Potassium ChannelsVoltage-gated sodium channel-associated proteins and alternative mechanisms of inactivation and blockNa+ channel function, regulation, structure, trafficking and sequestrationResurgent current of voltage-gated Na(+) channelsExploring volatile general anesthetic binding to a closed membrane-bound bacterial voltage-gated sodium channel via computationAberrant sodium influx causes cardiomyopathy and atrial fibrillation in miceBisphenol A binds to the local anesthetic receptor site to block the human cardiac sodium channelThe crystal structure of a voltage-gated sodium channelCrystal structure of a voltage-gated sodium channel in two potentially inactivated statesProkaryotic NavMs channel as a structural and functional model for eukaryotic sodium channel antagonismAtom-by-atom engineering of voltage-gated ion channels: magnified insights into function and pharmacologyStructural Basis for Pharmacology of Voltage-Gated Sodium and Calcium ChannelsCytoplasmic polyamines as permeant blockers and modulators of the voltage-gated sodium channel.Distinct mechanisms of block of Kv1.5 channels by tertiary and quaternary amine clofilium compounds.Increased rigidity of the chiral centre of tocainide favours stereoselectivity and use-dependent block of skeletal muscle Na(+) channels enhancing the antimyotonic activity in vivoMexiletine block of disease-associated mutations in S6 segments of the human skeletal muscle Na(+) channelInteraction of batrachotoxin with the local anesthetic receptor site in transmembrane segment IVS6 of the voltage-gated sodium channelCommon molecular determinants of local anesthetic, antiarrhythmic, and anticonvulsant block of voltage-gated Na+ channelsPhenytoin inhibits the persistent sodium current in neocortical neurons by modifying its inactivation propertiesLocating the route of entry and binding sites of benzocaine and phenytoin in a bacterial voltage gated sodium channelComparison of Gating Properties and Use-Dependent Block of Nav1.5 and Nav1.7 Channels by Anti-Arrhythmics Mexiletine and LidocaineA Novel SCN5A Mutation Associated with Drug Induced Brugada Type ECGA molecular switch between the outer and the inner vestibules of the voltage-gated Na+ channelStructure and function of voltage-gated sodium channels at atomic resolution.The VGL-Chanome: A Protein Superfamily Specialized for Electrical Signaling and Ionic HomeostasisExploring the structure of the voltage-gated Na+ channel by an engineered drug access pathway to the receptor site for local anesthetics.Synthesis and biological evaluation of a fluorescent analog of phenytoin as a potential inhibitor of neuropathic pain and imaging agent.
P2860
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P2860
Molecular determinants of state-dependent block of Na+ channels by local anesthetics.
description
1994 nî lūn-bûn
@nan
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
1994年论文
@zh
1994年论文
@zh-cn
name
Molecular determinants of state-dependent block of Na+ channels by local anesthetics.
@en
Molecular determinants of state-dependent block of Na+ channels by local anesthetics.
@nl
type
label
Molecular determinants of state-dependent block of Na+ channels by local anesthetics.
@en
Molecular determinants of state-dependent block of Na+ channels by local anesthetics.
@nl
prefLabel
Molecular determinants of state-dependent block of Na+ channels by local anesthetics.
@en
Molecular determinants of state-dependent block of Na+ channels by local anesthetics.
@nl
P2093
P356
P1433
P1476
Molecular determinants of state-dependent block of Na+ channels by local anesthetics.
@en
P2093
Catterall WA
Ragsdale DS
P304
P356
10.1126/SCIENCE.8085162
P407
P577
1994-09-01T00:00:00Z