Interaction of batrachotoxin with the local anesthetic receptor site in transmembrane segment IVS6 of the voltage-gated sodium channel - Wikidata - wikimedia - TriplyDB

Interaction of batrachotoxin with the local anesthetic receptor site in transmembrane segment IVS6 of the voltage-gated sodium channel

Interaction of batrachotoxin with the local anesthetic receptor site in transmembrane segment IVS6 of the voltage-gated sodium channel

http://www.wikidata.org/entity/Q28369249

about

Molecular basis of ranolazine block of LQT-3 mutant sodium channels: evidence for site of action The hitchhiker's guide to the voltage-gated sodium channel galaxy Synthesis and biological evaluation of a fluorescent analog of phenytoin as a potential inhibitor of neuropathic pain and imaging agent.Asymmetric synthesis and evaluation of a hydroxyphenylamide voltage-gated sodium channel blocker in human prostate cancer xenografts Folding similarity of the outer pore region in prokaryotic and eukaryotic sodium channels revealed by docking of conotoxins GIIIA, PIIIA, and KIIIA in a NavAb-based model of Nav1.4.Antillatoxin is a marine cyanobacterial toxin that potently activates voltage-gated sodium channels Role of the C-terminal domain in inactivation of brain and cardiac sodium channels Batrachotoxin-resistant Na+ channels derived from point mutations in transmembrane segment D4-S6 A point mutation in domain 4-segment 6 of the skeletal muscle sodium channel produces an atypical inactivation state.Rapid and slow voltage-dependent conformational changes in segment IVS6 of voltage-gated Na(+) channels Residues in Na(+) channel D3-S6 segment modulate both batrachotoxin and local anesthetic affinities.Neurotoxins and their binding areas on voltage-gated sodium channels.The poison Dart frog's batrachotoxin modulates Nav1.8.Synergistic interaction between two cockroach sodium channel mutations and a tobacco budworm sodium channel mutation in reducing channel sensitivity to a pyrethroid insecticide.Alternative splicing of an insect sodium channel gene generates pharmacologically distinct sodium channels.Single point mutations affect fatty acid block of human myocardial sodium channel alpha subunit Na+ channels.Identification of new batrachotoxin-sensing residues in segment IIIS6 of the sodium channel.Functional properties and differential neuromodulation of Na(v)1.6 channels.An important role of a pyrethroid-sensing residue F1519 in the action of the N-alkylamide insecticide BTG 502 on the cockroach sodium channel.Batrachotoxin, pyrethroids, and BTG 502 share overlapping binding sites on insect sodium channels.Potent blockade of sodium channels and protection of brain tissue from ischemia by BIII 890 CL.Sodium channel inactivation: molecular determinants and modulation.Time-dependent block and resurgent tail currents induced by mouse beta4(154-167) peptide in cardiac Na+ channels.The external pore loop interacts with S6 and S3-S4 linker in domain 4 to assume an essential role in gating control and anticonvulsant action in the Na(+) channel Block of human cardiac sodium channels by lacosamide: evidence for slow drug binding along the activation pathway.Advances in targeting voltage-gated sodium channels with small molecules.Animal toxins influence voltage-gated sodium channel function.Sodium channel mutation leading to saxitoxin resistance in clams increases risk of PSP.Accessibility of mid-segment domain IV S6 residues of the voltage-gated Na+ channel to methanethiosulfonate reagents.Veratridine block of rat skeletal muscle Nav1.4 sodium channels in the inner vestibule.A "minimal" sodium channel construct consisting of ligated S5-P-S6 segments forms a toxin-activatable ionophore.Activation of Drosophila sodium channels promotes modification by deltamethrin. Reductions in affinity caused by knock-down resistance mutations.Cu2+ (1,10 phenanthroline)3 is an open-channel blocker of the human skeletal muscle sodium channel.Inhibition of Sodium Ion Channel Function with Truncated Forms of Batrachotoxin.The selectivity filter of the voltage-gated sodium channel is involved in channel activation.Molecular basis for exaggerated sensitivity to mexiletine in the cardiac isoform of the fast Na channel.Distinct sites regulating grayanotoxin binding and unbinding to D4S6 of Na(v)1.4 sodium channel as revealed by improved estimation of toxin sensitivity.Voltage-gated Na+ channel ligands and ATP: relative molecular similarity and implications for channel function.Toxins That Affect Voltage-Gated Sodium Channels.Single rat muscle Na+ channel mutation confers batrachotoxin autoresistance found in poison-dart frog Phyllobates terribilis.

P2860

Q24671796-F943C8FC-CD0B-47B4-BECB-BE42B542FD34 Q26771787-B2217D17-C074-49FC-914E-64A5D85ABA79 Q30411736-C03C4885-F638-4473-8E5D-556135768F89 Q30411740-D698F3FD-4F69-4BC6-896E-B30B99D3A7A9 Q30586316-B589FB16-95F2-4229-949C-F032AC31E984 Q33952224-76739457-6B3A-47CB-B291-D9320B11B3B1 Q33953193-73B8BDA3-692C-44BB-8124-1353E26C09ED Q34170654-340745E9-132C-4B7F-B527-A419C769764E Q34172404-CFF9F4DA-655F-4764-9BD9-540973D64DDC Q34173224-75BD4E44-E36F-4CDB-9BAF-4D436C9F46C5 Q34173845-CFA9C58B-27D6-4FF0-A9A8-44B2F030BBB4 Q34232755-95113222-BA14-42CE-818E-376CDBDA825C Q34552425-B06F3173-2D9C-4BD9-BB30-C5CE2229860B Q34626840-42DB02B0-D1DF-4014-B6B8-E4A0D215BE5F Q34708118-0A368FFF-21F6-42D3-A4CC-D662D3637E9B Q34756665-EEF05D5C-0BEE-44C5-B161-A66DBCDD7360 Q34787096-75149F97-D003-49AA-90AE-DC1F6A82504F Q34791973-D90B3EA9-A390-412B-ABC8-5909F34F32B4 Q35056655-C407A10D-8C0D-48AB-BB4D-A00DBF0C0841 Q35188075-76AE1FAE-7DCF-4947-BFF2-67204A0CAF37 Q35700595-3951557C-E76A-4AF3-A34C-C270CCCF688A Q36267779-940FB219-A740-40FD-93B8-5A7B8243B4F7 Q36295611-CB4327A9-99CB-4FE7-A29C-0E78316CE548 Q37280509-70576141-2B19-47C2-B563-BAEE5ECD047C Q37708117-3BA5A6D0-599E-4127-BC8F-2509A18A710F Q38040330-E780EFD2-F690-4F7F-BD61-35482B4712D9 Q38204930-5719F8A8-CAED-4C13-833F-FD5445AD5501 Q40437850-9B4FB0EC-E175-4E98-8261-5E0CF663DC12 Q40484843-8543A7A5-29AB-4B41-A28C-56A6614CE5AB Q40665411-269AFFA0-6D62-4D14-B651-68A7E4FE521C Q40735958-57A4F045-DE45-461F-8453-A746919E30F9 Q42002841-A50F27B7-8780-44D1-8135-880FEC8EBE56 Q42092804-31FFA1A0-7F2E-4335-A254-120AB10D43FA Q42345389-97AF0B22-814E-4F89-ACEE-501A26DDD825 Q43624026-DB60F4A8-1F20-4D43-BF6F-55459B7DA79C Q43923816-781472DB-F917-4A7C-9D3C-82DD70852617 Q44276048-EFACCDD7-C793-42F5-BC8A-96448E5D0D17 Q48666406-E042A0B9-608A-42CF-9D81-8E4F5EAF2F11 Q50086110-F4A770E5-4107-4B8F-9B48-6F724ED65362 Q50219502-88CCEEC1-5DE3-4C3D-8758-871DDCB43D53

P2860

Interaction of batrachotoxin with the local anesthetic receptor site in transmembrane segment IVS6 of the voltage-gated sodium channel

http://www.wikidata.org/entity/Q28369249

description

1998 nî lūn-bûn

@nan

1998 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

1998 թվականի նոյեմբերին հրատարակված գիտական հոդված

@hy

1998年の論文

@ja

1998年論文

@yue

1998年論文

@zh-hant

1998年論文

@zh-hk

1998年論文

@zh-mo

1998年論文

@zh-tw

1998年论文

@wuu

name

Interaction of batrachotoxin w ...... e voltage-gated sodium channel

@ast

Interaction of batrachotoxin w ...... e voltage-gated sodium channel

@en

Interaction of batrachotoxin w ...... e voltage-gated sodium channel

@nl

type

label

Interaction of batrachotoxin w ...... e voltage-gated sodium channel

@ast

Interaction of batrachotoxin w ...... e voltage-gated sodium channel

@en

Interaction of batrachotoxin w ...... e voltage-gated sodium channel

@nl

prefLabel

Interaction of batrachotoxin w ...... e voltage-gated sodium channel

@ast

Interaction of batrachotoxin w ...... e voltage-gated sodium channel

@en

Interaction of batrachotoxin w ...... e voltage-gated sodium channel

@nl

P1433

Q28369249-81E4791E-F299-4BC4-9E47-59BC49D88014

P1476

Q28369249-0CC73025-6213-471A-A792-37DB934103F2

P2093

Q28369249-2171D465-5315-484F-8E9A-8073FF4468B7

Q28369249-35DEA058-A76A-4E6C-B83C-1064141AF695

Q28369249-45AAA087-7088-4855-A993-E94050DA80DA

Q28369249-4EE297F4-8C06-4779-9119-694294CBADE5

Q28369249-6D4395D0-A045-4004-AF27-B2E81C86F3E7

P2860

Q28369249-04DF50E2-7101-47E1-87ED-087CF105C217

Q28369249-2C1B7523-C4FA-4368-89F0-D1B724DC5E49

Q28369249-33530061-AEC6-449E-B8AE-9FDEE6F7E9A9

Q28369249-3D8F8ACE-06E3-4C1C-A868-7BB78275C78D

Q28369249-4DE66192-8F91-49B0-8273-CAB937997622

Q28369249-5354B566-2D08-4205-8A71-DC036683A002

Q28369249-53979D45-F7D4-4FFE-B966-519B3643E58A

Q28369249-58591B3A-9C8B-4AB6-9FDA-0FA404C28CBC

Q28369249-59738235-1A4B-4A21-8B59-9B8613E17149

Q28369249-6014A519-EABC-408F-AAF6-D8C29316E4C8

P304

Q28369249-5D071853-CEB3-4233-BAA1-2291A537FEC7

P31

Q28369249-4BB91200-EA32-47A1-A6DE-09E9F4674F89

P356

Q28369249-E0470049-1FE7-47B6-9BE5-8BA8321807D8

P407

Q28369249-9A76934D-161B-4AF2-8AF8-1A3C41972DCF

P433

Q28369249-E75E3D97-BE69-4A32-8DE6-C23C23072A80

P478

Q28369249-1B85CE10-A5D9-465B-8A1D-154D3E4CC587

P577

Q28369249-2E68BEB4-F39B-4158-A34D-61757E584FAC

P5875

Q28369249-DEC4AD73-221A-4528-9321-04239CE82878

P698

Q28369249-2221005A-B7AF-46B0-B8E1-0AD636865771

P921

Q28369249-02B59C62-EF8F-4E6F-86DB-3905732B70EA

P932

Q28369249-3A215F80-A71E-40A4-B994-703CEE93DC59

P356

PNAS.95.23.13947

P1433

Proceedings of the National Academy of Sciences of the United States of America

P1476

Interaction of batrachotoxin w ...... e voltage-gated sodium channel

@en

P2093

A R Cantrell

http://www.w3.org/2001/XMLSchema#string

N J Linford

http://www.w3.org/2001/XMLSchema#string

T Scheuer

http://www.w3.org/2001/XMLSchema#string

W A Catterall

http://www.w3.org/2001/XMLSchema#string

Y Qu

http://www.w3.org/2001/XMLSchema#string

P2860

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

Common molecular determinants of local anesthetic, antiarrhythmic, and anticonvulsant block of voltage-gated Na+ channels

Point mutations in segment I-S6 render voltage-gated Na+ channels resistant to batrachotoxin

Fast lidocaine block of cardiac and skeletal muscle sodium channels: one site with two routes of access.

Modification of cardiac Na+ channels by batrachotoxin: effects on gating, kinetics, and local anesthetic binding.

Batrachotoxin: chemistry and pharmacology.

Molecular mechanisms of local anesthesia: a review.

Neurotoxins that act on voltage-sensitive sodium channels in excitable membranes.

Structure and function of voltage-gated ion channels.

Molecular determinants of high affinity binding of alpha-scorpion toxin and sea anemone toxin in the S3-S4 extracellular loop in domain IV of the Na+ channel alpha subunit.

P304

13947-52

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1073/PNAS.95.23.13947

http://www.w3.org/2001/XMLSchema#string

P407

P433

23

http://www.w3.org/2001/XMLSchema#string

P478

95

http://www.w3.org/2001/XMLSchema#string

P577

1998-11-10T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

13474567

http://www.w3.org/2001/XMLSchema#string

P698

9811906

http://www.w3.org/2001/XMLSchema#string

P921

transmembrane protein

P932

24981

http://www.w3.org/2001/XMLSchema#string