α-Synuclein binds and sequesters PIKE-L into Lewy bodies, triggering dopaminergic cell death via AMPK hyperactivation.

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Insights into the Mechanisms Involved in Protective Effects of VEGF-B in Dopaminergic Neurons.Modulating the catalytic activity of AMPK has neuroprotective effects against α-synuclein toxicity.Targeting AMPK Signaling as a Neuroprotective Strategy in Parkinson's Disease.

P2860

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P2860

α-Synuclein binds and sequesters PIKE-L into Lewy bodies, triggering dopaminergic cell death via AMPK hyperactivation.

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http://www.wikidata.org/entity/Q42323946

description

2017 nî lūn-bûn

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2017年の論文

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2017年論文

@yue

2017年論文

@zh-hant

2017年論文

@zh-hk

2017年論文

@zh-mo

2017年論文

@zh-tw

2017年论文

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2017年论文

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2017年论文

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name

α-Synuclein binds and sequeste ...... eath via AMPK hyperactivation.

@en

α-Synuclein binds and sequeste ...... eath via AMPK hyperactivation.

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type

Item

label

α-Synuclein binds and sequeste ...... eath via AMPK hyperactivation.

@en

α-Synuclein binds and sequeste ...... eath via AMPK hyperactivation.

@nl

prefLabel

α-Synuclein binds and sequeste ...... eath via AMPK hyperactivation.

@en

α-Synuclein binds and sequeste ...... eath via AMPK hyperactivation.

@nl

P1476

α-Synuclein binds and sequeste ...... eath via AMPK hyperactivation.

@en

P2093

Fredric P Manfredsson

http://www.w3.org/2001/XMLSchema#string

Keqiang Ye

http://www.w3.org/2001/XMLSchema#string

Li He

http://www.w3.org/2001/XMLSchema#string

Lingjing Jin

http://www.w3.org/2001/XMLSchema#string

P Michael Iuvone

http://www.w3.org/2001/XMLSchema#string

Seong Su Kang

http://www.w3.org/2001/XMLSchema#string

Xia Liu

http://www.w3.org/2001/XMLSchema#string

Xuebing Cao

http://www.w3.org/2001/XMLSchema#string

Yi E Sun

http://www.w3.org/2001/XMLSchema#string

P2860

Pike. A nuclear gtpase that enhances PI3kinase activity and is regulated by protein 4.1N

Proteomics analysis identifies phosphorylation-dependent alpha-synuclein protein interactions

Netrin-1 mediates neuronal survival through PIKE-L interaction with the dependence receptor UNC5B

Neuroprotective actions of PIKE-L by inhibition of SET proteolytic degradation by asparagine endopeptidase

Phosphoinositol lipids bind to phosphatidylinositol 3 (PI3)-kinase enhancer GTPase and mediate its stimulatory effect on PI3-kinase and Akt signalings

PIKE-A is amplified in human cancers and prevents apoptosis by up-regulating Akt

Fyn-dependent regulation of energy expenditure and body weight is mediated by tyrosine phosphorylation of LKB1

Constitutive phosphorylation of the Parkinson's disease associated alpha-synuclein

PI3 kinase enhancer-Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosis

Phospholipase C gamma 1 is a physiological guanine nucleotide exchange factor for the nuclear GTPase PIKE

P304

1183-1188

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P31

scholarly article

P356

10.1073/PNAS.1618627114

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P407

English

P433

http://www.w3.org/2001/XMLSchema#string

P478

114

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P50

Zhentao Zhang

P577

2017-01-17T00:00:00Z

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P698

28096359

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P921

dopamine

Synuclein

P932

5293033

http://www.w3.org/2001/XMLSchema#string

α-Synuclein binds and sequesters PIKE-L into Lewy bodies, triggering dopaminergic cell death via AMPK hyperactivation.

about

P2860

P2860

α-Synuclein binds and sequesters PIKE-L into Lewy bodies, triggering dopaminergic cell death via AMPK hyperactivation.

description

name

type

label

prefLabel

P1433

P1476

P2093

P2860

P304

P31

P356

P407

P433

P478

P50

P577

P698

P921

P932

P356

P1433

P1476

P2093

P2860

P304

P31

P356

P407

P433

P478

P50

P577

P698

P921

P932