Differential signaling of the endogenous agonists at the beta2-adrenergic receptor
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Fluorescent approaches for understanding interactions of ligands with G protein coupled receptorsSingle-cell analysis of G-protein signal transductionMultidisciplinary Consideration of Potential Pathophysiologic Mechanisms of Paradoxical Erythema with Topical Brimonidine Therapyβ1-Adrenergic receptors activate two distinct signaling pathways in striatal neuronsDivergent label-free cell phenotypic pharmacology of ligands at the overexpressed β₂-adrenergic receptors.Recognition in the face of diversity: interactions of heterotrimeric G proteins and G protein-coupled receptor (GPCR) kinases with activated GPCRsMultiplex detection of homo- and heterodimerization of g protein-coupled receptors by proximity biotinylationQuantifying ligand bias at seven-transmembrane receptors.Emerging paradigms of β-arrestin-dependent seven transmembrane receptor signalingAmyloid beta peptide-(1-42) induces internalization and degradation of beta2 adrenergic receptors in prefrontal cortical neuronsBiased signaling: potential agonist and antagonist of PAR2.Multiple ligand-specific conformations of the β2-adrenergic receptorRecording kinetics of adrenergic receptor activation in live cells.Recruitment of β-arrestin 1 and 2 to the β2-adrenoceptor: analysis of 65 ligands.Single-molecule view of basal activity and activation mechanisms of the G protein-coupled receptor β2AR.Advances in receptor conformation research: the quest for functionally selective conformations focusing on the β2-adrenoceptorMolecular mechanism of β-arrestin-biased agonism at seven-transmembrane receptorsTherapeutic potential of β-arrestin- and G protein-biased agonists.Sex-specific cell signaling: the corticotropin-releasing factor receptor model.Functionally biased signalling properties of 7TM receptors - opportunities for drug development for the ghrelin receptor.Desensitization of human CRF2(a) receptor signaling governed by agonist potency and βarrestin2 recruitment.Ligand functional selectivity and quantitative pharmacology at G protein-coupled receptors.How ligands and signalling proteins affect G-protein-coupled receptors' conformational landscape.Sequential inter- and intrasubunit rearrangements during activation of dimeric metabotropic glutamate receptor 1.Ligand-dependent perturbation of the conformational ensemble for the GPCR β2 adrenergic receptor revealed by HDX.The ins and outs of adrenergic signaling.Optical probes based on G protein-coupled receptors - added work or added value?S-Palmitoylation of a Novel Site in the β2-Adrenergic Receptor Associated with a Novel Intracellular ItineraryConducting the G-protein Coupled Receptor (GPCR) Signaling Symphony in Cardiovascular Diseases: New Therapeutic ApproachesG protein stoichiometry dictates biased agonism through distinct receptor-G protein partitioning.Structure-bias relationships for fenoterol stereoisomers in six molecular and cellular assays at the β2-adrenoceptor.Distinct Conformational Dynamics of Three G Protein-Coupled Receptors Measured Using FlAsH-BRET BiosensorsReal time analysis of β(2)-adrenoceptor-mediated signaling kinetics in human primary airway smooth muscle cells reveals both ligand and dose dependent differences.Divergent agonist selectivity in activating β1- and β2-adrenoceptors for G-protein and arrestin coupling.Time-gated detection of protein-protein interactions with transcriptional readout.Bioluminescence resonance energy transfer-based biosensors allow monitoring of ligand- and transducer-mediated GPCR conformational changesA universal bioluminescence resonance energy transfer sensor design enables high-sensitivity screening of GPCR activation dynamics
P2860
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P2860
Differential signaling of the endogenous agonists at the beta2-adrenergic receptor
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
2010年论文
@zh
2010年论文
@zh-cn
name
Differential signaling of the endogenous agonists at the beta2-adrenergic receptor
@en
Differential signaling of the endogenous agonists at the beta2-adrenergic receptor
@nl
type
label
Differential signaling of the endogenous agonists at the beta2-adrenergic receptor
@en
Differential signaling of the endogenous agonists at the beta2-adrenergic receptor
@nl
prefLabel
Differential signaling of the endogenous agonists at the beta2-adrenergic receptor
@en
Differential signaling of the endogenous agonists at the beta2-adrenergic receptor
@nl
P2093
P2860
P356
P1476
Differential signaling of the endogenous agonists at the beta2-adrenergic receptor
@en
P2093
Carsten Hoffmann
Manuela Ambrosio
Susanne Reiner
P2860
P304
36188-36198
P356
10.1074/JBC.M110.175604
P407
P577
2010-09-13T00:00:00Z