Identifying Determinants of EGFR-Targeted Therapeutic Biochemical Efficacy Using Computational Modeling.

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Cell signaling regulation by protein phosphorylation: a multivariate, heterogeneous, and context-dependent process.

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Identifying Determinants of EGFR-Targeted Therapeutic Biochemical Efficacy Using Computational Modeling.

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2014 nî lūn-bûn

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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2014年论文

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Identifying Determinants of EG ...... Using Computational Modeling.

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Identifying Determinants of EG ...... Using Computational Modeling.

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Identifying Determinants of EG ...... Using Computational Modeling.

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Identifying Determinants of EG ...... Using Computational Modeling.

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Identifying Determinants of EG ...... Using Computational Modeling.

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Identifying Determinants of EG ...... Using Computational Modeling.

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Identifying Determinants of EG ...... Using Computational Modeling.

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C S Monast

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M J Lazzara

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P2860

Structure and function of human amphiregulin: a member of the epidermal growth factor family

Hierarchy of binding sites for Grb2 and Shc on the epidermal growth factor receptor

Oncogenic mutations counteract intrinsic disorder in the EGFR kinase and promote receptor dimerization

A single ligand is sufficient to activate EGFR dimers

Reactivation of ERK signaling causes resistance to EGFR kinase inhibitors.

Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras

Grb2 regulates internalization of EGF receptors through clathrin-coated pits.

Multiple-state reactions between the epidermal growth factor receptor and Grb2 as observed by using single-molecule analysis.

Role of network branching in eliciting differential short-term signaling responses in the hypersensitive epidermal growth factor receptor mutants implicated in lung cancer

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e141

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scholarly article

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10.1038/PSP.2014.39

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2014-10-15T00:00:00Z

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266946963

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25317724

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4474171

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Identifying Determinants of EGFR-Targeted Therapeutic Biochemical Efficacy Using Computational Modeling.

about

P2860

P2860

Identifying Determinants of EGFR-Targeted Therapeutic Biochemical Efficacy Using Computational Modeling.

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