OTX2 is critical for the maintenance and progression of Shh-independent medulloblastomas.
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Pediatric medulloblastoma - update on molecular classification driving targeted therapiesMolecular subgroups of medulloblastoma: the current consensusExpression of the homeobox genes OTX2 and OTX1 in the early developing human brainAberrant Otx2 expression enhances migration and induces ectopic proliferation of hindbrain neuronal progenitor cellsHedgehog pathway inhibitor saridegib (IPI-926) increases lifespan in a mouse medulloblastoma modelA Proteogenomic Approach to Understanding MYC Function in Metastatic Medulloblastoma TumorsSubgroup-specific structural variation across 1,000 medulloblastoma genomesThe genetic landscape of the childhood cancer medulloblastomaCerebellum development and medulloblastomaDevelopment and cancer of the cerebellumConditional deletion of N-Myc disrupts neurosensory and non-sensory development of the ear.The prenatal origins of cancerInhibition of nuclear factor kappa-B signaling reduces growth in medulloblastoma in vivo.Joint binding of OTX2 and MYC in promotor regions is associated with high gene expression in medulloblastoma.Deregulated proliferation and differentiation in brain tumors.Molecular subgroups of medulloblastoma.Chromatin accessibility mapping identifies mediators of basal transcription and retinoid-induced repression of OTX2 in medulloblastoma.Effective treatment of diverse medulloblastoma models with mebendazole and its impact on tumor angiogenesis.Molecular diagnostics in embryonal brain tumors.TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewalOTX2 represses myogenic and neuronal differentiation in medulloblastoma cells.Embryonal central nervous system neoplasms arising in infants and young children: a pediatric brain tumor consortium studyMicroarray expression profiling identifies genes, including cytokines, and biofunctions, as diapedesis, associated with a brain metastasis from a papillary thyroid carcinoma.Neuroendocrine prostate cancer xenografts with large-cell and small-cell features derived from a single patient's tumor: morphological, immunohistochemical, and gene expression profiles.Medulloblastomics: the end of the beginning.Cytogenetic prognostication within medulloblastoma subgroups.Microarray discovery of new OGT substrates: the medulloblastoma oncogene OTX2 is O-GlcNAcylated.The clinical implications of medulloblastoma subgroups.The role of chromatin remodeling in medulloblastoma.RNA binding protein-mediated post-transcriptional gene regulation in medulloblastoma.Medulloblastoma development: tumor biology informs treatment decisionsThe kinesin KIF14 is overexpressed in medulloblastoma and downregulation of KIF14 suppressed tumor proliferation and induced apoptosis.OTX2 Activity at Distal Regulatory Elements Shapes the Chromatin Landscape of Group 3 Medulloblastoma.OTX2 exhibits cell-context-dependent effects on cellular and molecular properties of human embryonic neural precursors and medulloblastoma cells.Establishment of a novel human medulloblastoma cell line characterized by highly aggressive stem-like cells.OTX2 expression contributes to proliferation and progression in Myc-amplified medulloblastoma.Medulloblastoma: molecular pathways and histopathological classification.MiR-206, a Cerebellum Enriched miRNA Is Downregulated in All Medulloblastoma Subgroups and Its Overexpression Is Necessary for Growth Inhibition of Medulloblastoma Cells.OTX2 sustains a bivalent-like state of OTX2-bound promoters in medulloblastoma by maintaining their H3K27me3 levels.OTX2 directly activates cell cycle genes and inhibits differentiation in medulloblastoma cells.
P2860
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P2860
OTX2 is critical for the maintenance and progression of Shh-independent medulloblastomas.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
2009年论文
@zh
2009年论文
@zh-cn
name
OTX2 is critical for the maintenance and progression of Shh-independent medulloblastomas.
@en
OTX2 is critical for the maintenance and progression of Shh-independent medulloblastomas.
@nl
type
label
OTX2 is critical for the maintenance and progression of Shh-independent medulloblastomas.
@en
OTX2 is critical for the maintenance and progression of Shh-independent medulloblastomas.
@nl
prefLabel
OTX2 is critical for the maintenance and progression of Shh-independent medulloblastomas.
@en
OTX2 is critical for the maintenance and progression of Shh-independent medulloblastomas.
@nl
P2093
P2860
P1433
P1476
OTX2 is critical for the maintenance and progression of Shh-independent medulloblastomas.
@en
P2093
Christopher G Duncan
Chunhui Di
David C Adamson
Jianjun Li
Matthew Wortham
Michael D Taylor
Paul A Northcott
P2860
P304
P356
10.1158/0008-5472.CAN-09-2331
P407
P577
2009-12-22T00:00:00Z