Drug metabolism in hepatocyte sandwich cultures of rats and humans.
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Effect of rifampin and nelfinavir on the metabolism of methadone and buprenorphine in primary cultures of human hepatocytesMaturation of induced pluripotent stem cell derived hepatocytes by 3D-cultureThe influence of glycosaminoglycans and crosslinking agents on the phenotype of hepatocytes cultured on collagen gels.Characterization of the secreted proteome of rat hepatocytes cultured in collagen sandwiches.A novel ultrathin collagen nanolayer assembly for 3-D microtissue engineering: Layer-by-layer collagen deposition for long-term stable microfluidic hepatocyte cultureMaintenance of human hepatocyte function in vitro by liver-derived extracellular matrix gels.A commentary on the use of hepatocytes in drug metabolism studies during drug discovery and development.Gene expression profiling and differentiation assessment in primary human hepatocyte cultures, established hepatoma cell lines, and human liver tissuesSandwich-cultured hepatocytes: utility for in vitro exploration of hepatobiliary drug disposition and drug-induced hepatotoxicity.Interactions between the cytochrome P450 system and the second-generation antipsychotics.Microengineered cell and tissue systems for drug screening and toxicology applications: Evolution of in-vitro liver technologies.Effects of cytochrome P450 inducers on 17alpha-ethinyloestradiol (EE2) conjugation by primary human hepatocytesDetection of nanolevel drug metabolites in an organotypic culture of primary human hepatocytes and porcine hepatocytes with special reference to a two-compartment model.Cell-based models to study hepatic drug metabolism and enzyme induction in humans.Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.Hepatotoxicity and hepatic metabolism of available drugs: current problems and possible solutions in preclinical stages.Development of novel tools for the in vitro investigation of drug-induced liver injury.Prediction of human pharmacokinetics--evaluation of methods for prediction of hepatic metabolic clearance.Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease.Manipulation of the phenotype of immortalised rat hepatocytes by different culture configurations and by dimethyl sulphoxide.Hepatic Differentiation of Human Induced Pluripotent Stem Cells in a Perfused Three-Dimensional Multicompartment Bioreactor.Generation of proliferating human hepatocytes using Upcyte® technology: characterisation and applications in induction and cytotoxicity assays.Longterm stability of phase I and phase II enzymes of porcine liver cells in flat membrane bioreactors.Collagen sandwich culture affects intracellular polyamine levels of human hepatocytes.In vitro models of xenobiotic metabolism in trout for use in environmental bioaccumulation studies.Cryopreserved rat, dog and monkey hepatocytes: measurement of drug metabolizing enzymes in suspensions and cultures.The in vivo and in vitro phase I metabolism of FYL-67, a novel oxazolidinone antibacterial drug, studied by LC-MS/MS.Biotransformation of diazepam in a clinically relevant flat membrane bioreactor model using primary porcine hepatocytes.Metabolism of ibuprofen in zebrafish larvae.Evaluation of 309 molecules as inducers of CYP3A4, CYP2B6, CYP1A2, OATP1B1, OCT1, MDR1, MRP2, MRP3 and BCRP in cryopreserved human hepatocytes in sandwich culture.Cytochrome P450 enzyme activity and protein expression in primary porcine enterocyte and hepatocyte cultures.Proliferating primary hepatocytes from the pUR288 lacZ plasmid mouse are valuable tools for genotoxicity assessment in vitro
P2860
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P2860
Drug metabolism in hepatocyte sandwich cultures of rats and humans.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
Drug metabolism in hepatocyte sandwich cultures of rats and humans.
@en
Drug metabolism in hepatocyte sandwich cultures of rats and humans.
@nl
type
label
Drug metabolism in hepatocyte sandwich cultures of rats and humans.
@en
Drug metabolism in hepatocyte sandwich cultures of rats and humans.
@nl
prefLabel
Drug metabolism in hepatocyte sandwich cultures of rats and humans.
@en
Drug metabolism in hepatocyte sandwich cultures of rats and humans.
@nl
P2093
P1476
Drug metabolism in hepatocyte sandwich cultures of rats and humans.
@en
P2093
P304
P356
10.1016/S0006-2952(97)00204-9
P407
P577
1997-10-01T00:00:00Z