Integrative genomic analyses on GLI1: positive regulation of GLI1 by Hedgehog-GLI, TGFbeta-Smads, and RTK-PI3K-AKT signals, and negative regulation of GLI1 by Notch-CSL-HES/HEY, and GPCR-Gs-PKA signals.
about
The crosstalk of mTOR/S6K1 and Hedgehog pathwaysTamoxifen Resistance: Emerging Molecular TargetsA novel synthetic smoothened antagonist transiently inhibits pancreatic adenocarcinoma xenografts in a mouse modelMiR-133b is frequently decreased in gastric cancer and its overexpression reduces the metastatic potential of gastric cancer cells.Inactivation of the transcription factor GLI1 accelerates pancreatic cancer progression.Hedgehog signaling in the normal and neoplastic mammary gland.Hedgehog signaling antagonist GDC-0449 (Vismodegib) inhibits pancreatic cancer stem cell characteristics: molecular mechanisms.GANT-61 inhibits pancreatic cancer stem cell growth in vitro and in NOD/SCID/IL2R gamma null mice xenograftNotch inhibitors for cancer treatment.Genome-wide screening reveals an EMT molecular network mediated by Sonic hedgehog-Gli1 signaling in pancreatic cancer cells.Integrative genomic analyses of a novel cytokine, interleukin-34 and its potential role in cancer prediction.Gli1 activation and protection against hepatic encephalopathy is suppressed by circulating transforming growth factor β1 in mice.The Notch target Hes1 directly modulates Gli1 expression and Hedgehog signaling: a potential mechanism of therapeutic resistance.Decrease of miR-202-3p expression, a novel tumor suppressor, in gastric cancer.Significance of glioma-associated oncogene homolog 1 (GLI1) expression in claudin-low breast cancer and crosstalk with the nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB) pathway.WNT3 inhibits cerebellar granule neuron progenitor proliferation and medulloblastoma formation via MAPK activation.Association between the polymorphism rs3217927 of CCND2 and the risk of childhood acute lymphoblastic leukemia in a Chinese population.Hedgehog controls hepatic stellate cell fate by regulating metabolismIdentification of stem-like cells and clinical significance of candidate stem cell markers in gastric cancer.Hedgehog signaling regulates hypoxia induced epithelial to mesenchymal transition and invasion in pancreatic cancer cells via a ligand-independent mannerGalectin-1 from cancer-associated fibroblasts induces epithelial-mesenchymal transition through β1 integrin-mediated upregulation of Gli1 in gastric cancer.Indirect modulation of Shh signaling by Dlx5 affects the oral-nasal patterning of palate and rescues cleft palate in Msx1-null mice.Numb-like (NumbL) downregulation increases tumorigenicity, cancer stem cell-like properties and resistance to chemotherapy.Hedgehog signaling in the liver.Emerging from their burrow: Hedgehog pathway inhibitors for cancer.Notch pathway activity identifies cells with cancer stem cell-like properties and correlates with worse survival in lung adenocarcinoma.The DNA methyltransferase inhibitor zebularine exerts antitumor effects and reveals BATF2 as a poor prognostic marker for childhood medulloblastoma.Collagen I regulates the self-renewal of mouse embryonic stem cells through α2β1 integrin- and DDR1-dependent Bmi-1.Curcumin regulates cell fate and metabolism by inhibiting hedgehog signaling in hepatic stellate cells.Dual degradation signals destruct GLI1: AMPK inhibits GLI1 through β-TrCP-mediated proteasome degradationAberrant Signaling Pathways in T-Cell Acute Lymphoblastic Leukemia.Atoh1 inhibits neuronal differentiation and collaborates with Gli1 to generate medulloblastoma-initiating cells.Blockade of hedgehog pathway is required for the protective effects of magnesium isoglycyrrhizinate against ethanol-induced hepatocyte steatosis and apoptosis.Characterization of the pleiotropic roles of Sonic Hedgehog during retinal regeneration in adult zebrafish.Nuclear expression of glioma-associated oncogene homolog 1 and nuclear factor-κB is associated with a poor prognosis of pancreatic cancer.Exendin-4 promotes the osteogenic differentiation of osteoblasts via the Hedgehog/Gli1 signaling pathway.Targeting of miR-150 on Gli1 gene to inhibit proliferation and cell cycle of esophageal carcinoma EC9706.HES1 as an independent prognostic marker in esophageal squamous cell carcinoma.Glaucocalyxin A exerts anticancer effect on osteosarcoma by inhibiting GLI1 nuclear translocation via regulating PI3K/Akt pathway.
P2860
Q24308749-67804C5D-7B86-49DF-BD8E-AA6AD4243D6CQ26739969-D2361ED5-B436-4C05-9D2B-D8878F315C63Q28478580-9BFE6CE0-887D-41F5-8802-97F482100B56Q31148368-541CF882-FB0A-43EE-9E2D-1EAC25ADD286Q33718581-1F6474E2-E65B-4243-97B5-3505F64757B8Q33878004-60BB9B0F-820B-4499-9E92-42D1ADE1D40CQ34075584-0A631A7E-9B20-4E6E-B3D7-53F2A47BF9FCQ34129830-C8DD7A73-AED6-4C73-8462-BC64841C7EFDQ34330869-24CAC725-BF5D-470C-874C-A318AD2D8F48Q34382807-B6C86335-4C34-4608-9D85-D7AABC9ADDC7Q34599064-76C80882-E590-47C1-A751-D74DE466AC50Q34620012-74197A12-488A-42B4-A710-AB47049E0002Q34688196-95D7E895-57CF-41D8-9D68-D82E12321A1CQ34921140-92E39E99-20D9-41FA-92F0-33ECE4667584Q35000293-E4BE55FF-555D-4272-8065-AC9C06FF51A7Q35058659-86F5B7CA-3A8E-409B-B7A6-0A57C7E23A27Q35151947-E836D633-1426-42A9-82F9-EE59CC4828C4Q36345406-CB5D2130-E4B6-4531-A934-7E7C7FE906EBQ36962804-89C6CD2D-C29E-480B-A10A-8A0FD11C34B8Q36976060-FB6D8AF7-0772-4FCC-B275-2B6D6846CA77Q37410368-B5045B68-39D8-4571-A35D-A3E75258162BQ37429788-400F3EEC-7D30-4CB2-900B-6BDB0F14DE5AQ37665411-B9A17069-13B7-434A-8F0C-A100F74E0FECQ37811158-703201BD-8E95-4B58-B8E4-F25FFB1BFDC9Q38908981-94FE2B55-D782-465D-8DBB-0D586894F4D2Q39187994-31830FB3-D894-4E6E-BD9F-D01829A865A2Q39245345-DDA991A0-F75F-4B08-96EF-A2E0147EEB0CQ39587487-80C0A8D7-2BCE-4E3D-808D-A0C4AD05F6B0Q40979935-DEA87780-A94D-4674-B836-38479B1B26D6Q41472801-E88BF007-CBE6-4F77-9E6D-348EBDCDB9FCQ41660964-2A236022-B4F7-450E-BB3E-E87AC6B30C1CQ42721585-1D6F0DD8-AC9F-4038-98B3-9A046118233DQ46366543-2DF2C6FC-7A33-4A7B-B545-D2B483DC8D2FQ47798527-C47F651A-2FA7-4EBA-909D-364B230FD5E8Q47996655-AFA1CFA1-CB8D-491D-AF4F-99DF1A4838DFQ49371368-A75D05E9-219B-4234-9313-1AC0D139EAC9Q52747348-42D2A81A-04AE-45BF-ADD3-065CEBF05626Q53026426-9ED9FDC9-D1D4-4469-8C31-3074F70B6C06Q55332538-73554375-632D-4470-86D4-4B7F9A9C6790
P2860
Integrative genomic analyses on GLI1: positive regulation of GLI1 by Hedgehog-GLI, TGFbeta-Smads, and RTK-PI3K-AKT signals, and negative regulation of GLI1 by Notch-CSL-HES/HEY, and GPCR-Gs-PKA signals.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
2009年论文
@zh
2009年论文
@zh-cn
name
Integrative genomic analyses o ...... /HEY, and GPCR-Gs-PKA signals.
@en
Integrative genomic analyses o ...... /HEY, and GPCR-Gs-PKA signals.
@nl
type
label
Integrative genomic analyses o ...... /HEY, and GPCR-Gs-PKA signals.
@en
Integrative genomic analyses o ...... /HEY, and GPCR-Gs-PKA signals.
@nl
prefLabel
Integrative genomic analyses o ...... /HEY, and GPCR-Gs-PKA signals.
@en
Integrative genomic analyses o ...... /HEY, and GPCR-Gs-PKA signals.
@nl
P356
P1476
Integrative genomic analyses o ...... /HEY, and GPCR-Gs-PKA signals.
@en
P2093
Masaru Katoh
Yuriko Katoh
P304
P356
10.3892/IJO_00000328
P577
2009-07-01T00:00:00Z