Hedgehog signaling antagonist GDC-0449 (Vismodegib) inhibits pancreatic cancer stem cell characteristics: molecular mechanisms. - Wikidata - wikimedia - TriplyDB

Hedgehog signaling antagonist GDC-0449 (Vismodegib) inhibits pancreatic cancer stem cell characteristics: molecular mechanisms.

Hedgehog signaling antagonist GDC-0449 (Vismodegib) inhibits pancreatic cancer stem cell characteristics: molecular mechanisms.

http://www.wikidata.org/entity/Q34075584

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Novel therapeutic targets for pancreatic cancer Cancer of the Pancreas: Molecular Pathways and Current Advancement in Treatment Pancreatic Cancer from Molecular Pathways to Treatment Opinion Anti-Cancer Stem-like Cell Compounds in Clinical Development - An Overview and Critical Appraisal Pancreatic cancer from bench to bedside: molecular pathways and treatment options Signal Transduction Pathways of EMT Induced by TGF-β, SHH, and WNT and Their Crosstalks Hedgehog signaling: modulation of cancer properies and tumor mircroenvironment State of the art biological therapies in pancreatic cancer Cancer stem cells: a metastasizing menace!Novel agents for advanced pancreatic cancer Hedgehog Signaling in the Maintenance of Cancer Stem Cells The Impact of Hedgehog Signaling Pathway on DNA Repair Mechanisms in Human Cancer Pancreatic cancer stem cells: emerging target for designing novel therapy Can nanomedicines kill cancer stem cells?Novel small molecules targeting ciliary transport of Smoothened and oncogenic Hedgehog pathway activation.EMT, CTCs and CSCs in tumor relapse and drug-resistance Translating discovery in zebrafish pancreatic development to human pancreatic cancer: biomarkers, targets, pathogenesis, and therapeutics Chemoresistance in prostate cancer cells is regulated by miRNAs and Hedgehog pathway Sonic hedgehog signaling inhibition provides opportunities for targeted therapy by sulforaphane in regulating pancreatic cancer stem cell self-renewal Design, Synthesis and Biological Evaluation of novel Hedgehog Inhibitors for treating Pancreatic Cancer.Cancer stem cell-specific scavenger receptor CD36 drives glioblastoma progression.Sonic hedgehog-Gli1 signaling pathway regulates the epithelial mesenchymal transition (EMT) by mediating a new target gene, S100A4, in pancreatic cancer cells Targeting the K-Ras--JNK axis eliminates cancer stem-like cells and prevents pancreatic tumor formation.GANT-61 inhibits pancreatic cancer stem cell growth in vitro and in NOD/SCID/IL2R gamma null mice xenograft Multiple drug resistance due to resistance to stem cells and stem cell treatment progress in cancer (Review).Embelin suppresses growth of human pancreatic cancer xenografts, and pancreatic cancer cells isolated from KrasG12D mice by inhibiting Akt and Sonic hedgehog pathways.Targeting cancer stem cells in solid tumors by vitamin D.The suture provides a niche for mesenchymal stem cells of craniofacial bones.New insights into pancreatic cancer stem cells.Inhibition of hedgehog signaling improves the anti-carcinogenic effects of docetaxel in prostate cancer.Hedgehog pathway as a drug target: Smoothened inhibitors in development.Activity of ABCG2 Is Regulated by Its Expression and Localization in DHT and Cyclopamine-Treated Breast Cancer Cells.Targeted cancer therapy--are the days of systemic chemotherapy numbered?Studying the role of the immune system on the antitumor activity of a Hedgehog inhibitor against murine osteosarcoma.PI3K/AKT/mTOR and sonic hedgehog pathways cooperate together to inhibit human pancreatic cancer stem cell characteristics and tumor growth.Cancer stem cells and chemoresistance: The smartest survives the raid NPV-LDE-225 (Erismodegib) inhibits epithelial mesenchymal transition and self-renewal of glioblastoma initiating cells by regulating miR-21, miR-128, and miR-200 Hedgehog signaling pathway and ovarian cancer.Micelle Mixtures for Coadministration of Gemcitabine and GDC-0449 To Treat Pancreatic Cancer.Cancer Stem Cells, EMT, and Developmental Pathway Activation in Pancreatic Tumors

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Hedgehog signaling antagonist GDC-0449 (Vismodegib) inhibits pancreatic cancer stem cell characteristics: molecular mechanisms.

http://www.wikidata.org/entity/Q34075584

description

2011 nî lūn-bûn

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2011 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

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2011 թվականի նոյեմբերին հրատարակված գիտական հոդված

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Hedgehog signaling antagonist ...... ristics: molecular mechanisms.

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Hedgehog signaling antagonist GDC-0449

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Hedgehog signaling antagonist ...... ristics: molecular mechanisms.

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Hedgehog signaling antagonist ...... ristics: molecular mechanisms.

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Hedgehog signaling antagonist ...... ristics: molecular mechanisms.

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Brahma N Singh

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Junsheng Fu

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Rakesh K Srivastava

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Sharmila Shankar

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P2860

Core signaling pathways in human pancreatic cancers revealed by global genomic analyses

Hedgehog signaling in animal development: paradigms and principles

Differential activities of Sonic hedgehog mediated by Gli transcription factors define distinct neuronal subtypes in the dorsal thalamus

Activation of the BCL2 promoter in response to Hedgehog/GLI signal transduction is predominantly mediated by GLI2

Cilia and developmental signaling

Resveratrol inhibits pancreatic cancer stem cell characteristics in human and KrasG12D transgenic mice by inhibiting pluripotency maintaining factors and epithelial-mesenchymal transition

The Sonic Hedgehog-Gli pathway regulates dorsal brain growth and tumorigenesis

Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer

Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial

Pancreatic cancer

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