ZAP-70 is constitutively associated with tyrosine-phosphorylated TCR zeta in murine thymocytes and lymph node T cells.
about
T cell receptor-independent basal signaling via Erk and Abl kinases suppresses RAG gene expressionMechanism of activation for Zap-70 catalytic activityThe kinase, SH3, and SH2 domains of Lck play critical roles in T-cell activation after ZAP-70 membrane localizationDifferential role of glycolipid-enriched membrane domains in glycoprotein VI- and integrin-mediated phospholipase Cgamma2 regulation in plateletsDistinct tyrosine phosphorylation sites in ZAP-70 mediate activation and negative regulation of antigen receptor functionStructural Features of the αβTCR Mechanotransduction Apparatus That Promote pMHC DiscriminationThe Emerging and Diverse Roles of Src-Like Adaptor Proteins in Health and DiseasePhosphorylation of SLP-76 by the ZAP-70 protein-tyrosine kinase is required for T-cell receptor functionThe protein tyrosine phosphatase PTPN4/PTP-MEG1, an enzyme capable of dephosphorylating the TCR ITAMs and regulating NF-kappaB, is dispensable for T cell development and/or T cell effector functionsPhosphorylation site dynamics of early T-cell receptor signalingRhoH GTPase recruits and activates Zap70 required for T cell receptor signaling and thymocyte developmentDisruption of epithelial gamma delta T cell repertoires by mutation of the Syk tyrosine kinaseThe Syk family of protein tyrosine kinases in T-cell activation and developmentT cell receptor (TCR) clustering in the immunological synapse integrates TCR and costimulatory signaling in selected T cells.Novel tools to dissect the dynamic regulation of TCR signaling by the kinase Csk and the phosphatase CD45Membrane association of the CD3ε signaling domain is required for optimal T cell development and function.CD45-Csk phosphatase-kinase titration uncouples basal and inducible T cell receptor signaling during thymic developmentITAM-mediated signaling by the T-cell antigen receptorProximity and orientation underlie signaling by the non-receptor tyrosine kinase ZAP70Engagement of T cell receptor triggers its recruitment to low-density detergent-insoluble membrane domains.Quantitative analysis of protein phosphorylations and interactions by multi-colour IP-FCM as an input for kinetic modelling of signalling networksBasal LAT-diacylglycerol-RasGRP1 signals in T cells maintain TCRα gene expressionDevelopment of thymically derived natural regulatory T cells.Class I negative CD8 T cells reveal the confounding role of peptide-transfer onto CD8 T cells stimulated with soluble H2-Kb molecules.Cross-reactivity in T-cell antigen recognition.The importance of LAT in the activation, homeostasis, and regulatory function of T cellsQuantitative phosphoproteomics reveals SLP-76 dependent regulation of PAG and Src family kinases in T cellsA discrete affinity-driven elevation of ZAP-70 kinase activity initiates negative selection.Lck regulates the threshold of activation in primary T cells, while both Lck and Fyn contribute to the magnitude of the extracellular signal-related kinase response.The tuberous sclerosis complex-mammalian target of rapamycin pathway maintains the quiescence and survival of naive T cells.Vav1 Regulates T-Cell Activation through a Feedback Mechanism and Crosstalk between the T-Cell Receptor and CD28.Altered peptide ligands induce quantitatively but not qualitatively different intracellular signals in primary thymocytes.ZAP-70 protein tyrosine kinase is constitutively targeted to the T cell cortex independently of its SH2 domainsThe pre-T cell receptor (TCR) complex is functionally coupled to the TCR-zeta subunitLck regulates the tyrosine phosphorylation of the T cell receptor subunits and ZAP-70 in murine thymocytes.ZAP-70 protein promotes tyrosine phosphorylation of T cell receptor signaling motifs (ITAMs) in immature CD4(+)8(+) thymocytes with limiting p56(lck).Glucocorticoids attenuate T cell receptor signaling.T cell development and T cell responses in mice with mutations affecting tyrosines 292 or 315 of the ZAP-70 protein tyrosine kinase.Reduced self-reactivity of an autoreactive T cell after activation with cross-reactive non-self-ligandSensory adaptation in naive peripheral CD4 T cells.
P2860
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P2860
ZAP-70 is constitutively associated with tyrosine-phosphorylated TCR zeta in murine thymocytes and lymph node T cells.
description
1994 nî lūn-bûn
@nan
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
1994年论文
@zh
1994年论文
@zh-cn
name
ZAP-70 is constitutively assoc ...... ocytes and lymph node T cells.
@en
ZAP-70 is constitutively assoc ...... ocytes and lymph node T cells.
@nl
type
label
ZAP-70 is constitutively assoc ...... ocytes and lymph node T cells.
@en
ZAP-70 is constitutively assoc ...... ocytes and lymph node T cells.
@nl
prefLabel
ZAP-70 is constitutively assoc ...... ocytes and lymph node T cells.
@en
ZAP-70 is constitutively assoc ...... ocytes and lymph node T cells.
@nl
P2093
P1433
P1476
ZAP-70 is constitutively assoc ...... ocytes and lymph node T cells.
@en
P2093
P304
P356
10.1016/1074-7613(94)90038-8
P407
P577
1994-11-01T00:00:00Z