T cell development and T cell responses in mice with mutations affecting tyrosines 292 or 315 of the ZAP-70 protein tyrosine kinase.
about
Structural Basis for Activation of ZAP-70 by Phosphorylation of the SH2-Kinase LinkerNegative regulation of T cell receptor signaling by Siglec-7 (p70/AIRM) and Siglec-9Phosphorylation of Tyr342 in the linker region of Syk is critical for Fc epsilon RI signaling in mast cellsOrganization of proximal signal initiation at the TCR:CD3 complex.Intramolecular regulatory switch in ZAP-70: analogy with receptor tyrosine kinases.Regulation of T cell receptor complex-mediated signaling by ubiquitin and ubiquitin-like modificationsAn evolutionary and structural perspective on T cell antigen receptor function.The catalytic activity of the kinase ZAP-70 mediates basal signaling and negative feedback of the T cell receptor pathway.Vav1 Regulates T-Cell Activation through a Feedback Mechanism and Crosstalk between the T-Cell Receptor and CD28.Allelic variant in CTLA4 alters T cell phosphorylation patternsRequirement for tyrosine residues 315 and 319 within zeta chain-associated protein 70 for T cell developmentA mouse with a loss-of-function mutation in the c-Cbl TKB domain shows perturbed thymocyte signaling without enhancing the activity of the ZAP-70 tyrosine kinaseQuantitative phosphoproteomic analysis of T cell receptor signaling in diabetes prone and resistant miceSyk and pTyr'd: Signaling through the B cell antigen receptorA hypomorphic allele of ZAP-70 reveals a distinct thymic threshold for autoimmune disease versus autoimmune reactivity.Stability of an autoinhibitory interface in the structure of the tyrosine kinase ZAP-70 impacts T cell receptor response.ZAP-70: an essential kinase in T-cell signalingT cell receptor dwell times control the kinase activity of Zap70.Tyrosine 315 determines optimal recruitment of ZAP-70 to the T cell antigen receptor.Intensity and duration of TCR signaling is limited by p38 phosphorylation of ZAP-70T293 and destabilization of the signalosome.
P2860
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P2860
T cell development and T cell responses in mice with mutations affecting tyrosines 292 or 315 of the ZAP-70 protein tyrosine kinase.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
2001年學術文章
@zh
2001年學術文章
@zh-hant
name
T cell development and T cell ...... AP-70 protein tyrosine kinase.
@ast
T cell development and T cell ...... AP-70 protein tyrosine kinase.
@en
type
label
T cell development and T cell ...... AP-70 protein tyrosine kinase.
@ast
T cell development and T cell ...... AP-70 protein tyrosine kinase.
@en
prefLabel
T cell development and T cell ...... AP-70 protein tyrosine kinase.
@ast
T cell development and T cell ...... AP-70 protein tyrosine kinase.
@en
P2093
P2860
P356
P1476
T cell development and T cell ...... AP-70 protein tyrosine kinase.
@en
P2093
Arrieumerlou C
Di Bartolo V
Malissen B
Malissen M
P2860
P304
P356
10.1084/JEM.194.4.491
P407
P577
2001-08-01T00:00:00Z