Functional effects of protein kinase C-mediated myofilament phosphorylation in human myocardium.
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Myofilament Calcium Sensitivity: Role in Regulation of In vivo Cardiac Contraction and RelaxationPhosphorylation of protein kinase C sites Ser42/44 decreases Ca(2+)-sensitivity and blunts enhanced length-dependent activation in response to protein kinase A in human cardiomyocytesThe MLCK-mediated alpha1-adrenergic inotropic effect in atrial myocardium is negatively modulated by PKCepsilon signalingThe cardiac-specific N-terminal region of troponin I positions the regulatory domain of troponin CProtein kinase C alpha and epsilon phosphorylation of troponin and myosin binding protein C reduce Ca2+ sensitivity in human myocardiumInterplay between troponin T phosphorylation and O-N-acetylglucosaminylation in ischaemic heart failureWhy does troponin I have so many phosphorylation sites? Fact and fancyQuantitative comparison of sarcomeric phosphoproteomes of neonatal and adult rat hearts.Transmural heterogeneity of cellular level power output is reduced in human heart failure.Proteomics analysis of the cardiac myofilament subproteome reveals dynamic alterations in phosphatase subunit distributionExcision of titin's cardiac PEVK spring element abolishes PKCalpha-induced increases in myocardial stiffnessLeft ventricular and myocardial function in mice expressing constitutively pseudophosphorylated cardiac troponin I.Troponin I phosphorylation in human myocardium in health and disease.PKCĪ±-specific phosphorylation of the troponin complex in human myocardium: a functional and proteomics analysis.Myocardial stiffness in patients with heart failure and a preserved ejection fraction: contributions of collagen and titinConstitutive phosphorylation of cardiac myosin regulatory light chain in vivoAugmented phosphorylation of cardiac troponin I in hypertensive heart failure.Myocyte shape regulates lateral registry of sarcomeres and contractility.Tropomyosin dephosphorylation results in compensated cardiac hypertrophyImpact of site-specific phosphorylation of protein kinase A sites Ser23 and Ser24 of cardiac troponin I in human cardiomyocytesProtein kinase C depresses cardiac myocyte power output and attenuates myofilament responses induced by protein kinase ARate-dependent force, intracellular calcium, and action potential voltage alternans are modulated by sarcomere length and heart failure induced-remodeling of thin filament regulation in human heart failure: A myocyte modeling study.Proteomic technologies in the study of kinases: novel tools for the investigation of PKC in the heart.Contractile protein phosphorylation predicts human heart disease phenotypesCardiac function and modulation of sarcomeric function by length.Human heart failure is accompanied by altered protein kinase A subunit expression and post-translational state.Cardiac myosin binding protein C phosphorylation in cardiac disease.Pathomechanisms in heart failure: the contractile connection.O-GlcNAcylation and cardiovascular disease.The role of protein kinase C-mediated phosphorylation of sarcomeric proteins in the heart-detrimental or beneficial?Historical perspective on heart function: the Frank-Starling Law.Effect of troponin I Ser23/24 phosphorylation on Ca2+-sensitivity in human myocardium depends on the phosphorylation background.Self-folded redox/acid dual-responsive nanocarriers for anticancer drug delivery.Genetically Encoded Biosensors Reveal PKA Hyperphosphorylation on the Myofilaments in Rabbit Heart Failure.Restoration of diabetes-induced abnormal local Ca2+ release in cardiomyocytes by angiotensin II receptor blockade.Bradykinin restores left ventricular function, sarcomeric protein phosphorylation, and e/nNOS levels in dogs with Duchenne muscular dystrophy cardiomyopathy.A new state of cardiac myosin with very slow ATP turnover: a potential cardioprotective mechanism in the heartProtein kinase C contributes to the maintenance of contractile force in human ventricular cardiomyocytes.The continuing evolution of cardiac troponin I biomarker analysis: from protein to proteoform.Altered myocardial force generation in end-stage human heart failure.
P2860
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P2860
Functional effects of protein kinase C-mediated myofilament phosphorylation in human myocardium.
description
2005 nĆ® lÅ«n-bĆ»n
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2005幓ć®č«ę
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2005幓č«ę
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2005幓č«ę
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2005幓č«ę
@zh-hk
2005幓č«ę
@zh-mo
2005幓č«ę
@zh-tw
2005幓č®ŗę
@wuu
2005幓č®ŗę
@zh
2005幓č®ŗę
@zh-cn
name
Functional effects of protein ...... orylation in human myocardium.
@en
Functional effects of protein ...... orylation in human myocardium.
@nl
type
label
Functional effects of protein ...... orylation in human myocardium.
@en
Functional effects of protein ...... orylation in human myocardium.
@nl
prefLabel
Functional effects of protein ...... orylation in human myocardium.
@en
Functional effects of protein ...... orylation in human myocardium.
@nl
P2093
P1476
Functional effects of protein ...... horylation in human myocardium
@en
P2093
Attila BorbƩly
Jean G F Bronzwaer
Kornelia Jaquet
Nadiya A Narolska
Nicky M Boontje
Regis R Lamberts
Ruud Zaremba
Walter J Paulus
Zoltan Papp
P304
P356
10.1016/J.CARDIORES.2005.11.021
P577
2005-12-27T00:00:00Z