Isatin replacements applied to the highly selective, muscarinic M1 PAM ML137: continued optimization of an MLPCN probe molecule
about
Discovery of ML326: The first sub-micromolar, selective M5 PAMAllosteric modulation of the M1 muscarinic acetylcholine receptor: improving cognition and a potential treatment for schizophrenia and Alzheimer's diseaseDevelopment of allosteric modulators of GPCRs for treatment of CNS disordersDiscovery and SAR of muscarinic receptor subtype 1 (M1) allosteric activators from a molecular libraries high throughput screen. Part 1: 2,5-dibenzyl-2H-pyrazolo[4,3-c]quinolin-3(5H)-ones as positive allosteric modulators.Development of M1 mAChR allosteric and bitopic ligands: prospective therapeutics for the treatment of cognitive deficitsDiverse Effects on M1 Signaling and Adverse Effect Liability within a Series of M1 Ago-PAMs.Spirocyclic replacements for the isatin in the highly selective, muscarinic M1 PAM ML137: the continued optimization of an MLPCN probe molecule.Further optimization of the M1 PAM VU0453595: Discovery of novel heterobicyclic core motifs with improved CNS penetrationPrefrontal Cortex-Mediated Impairments in a Genetic Model of NMDA Receptor Hypofunction Are Reversed by the Novel M1 PAM VU6004256.Structure-Activity Relationships of Pan-Gα Coupled Muscarinic Acetylcholine Receptor Positive Allosteric Modulators
P2860
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P2860
Isatin replacements applied to the highly selective, muscarinic M1 PAM ML137: continued optimization of an MLPCN probe molecule
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Isatin replacements applied to ...... ion of an MLPCN probe molecule
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Isatin replacements applied to ...... ion of an MLPCN probe molecule
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label
Isatin replacements applied to ...... ion of an MLPCN probe molecule
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Isatin replacements applied to ...... ion of an MLPCN probe molecule
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Isatin replacements applied to ...... ion of an MLPCN probe molecule
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Isatin replacements applied to ...... ion of an MLPCN probe molecule
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P2093
P2860
P50
P1476
Isatin replacements applied to ...... ion of an MLPCN probe molecule
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P2093
Bruce J Melancon
Douglas J Sheffler
J Scott Daniels
James C Tarr
Margrith E Mattmann
Michael R Wood
Michael S Poslusney
Patrick R Gentry
Thomas J Utley
Thomas M Bridges
P2860
P304
P356
10.1016/J.BMCL.2012.11.092
P407
P577
2012-12-01T00:00:00Z