CFTR channel opening by ATP-driven tight dimerization of its nucleotide-binding domains. - Wikidata - wikimedia - TriplyDB

CFTR channel opening by ATP-driven tight dimerization of its nucleotide-binding domains.

CFTR channel opening by ATP-driven tight dimerization of its nucleotide-binding domains.

http://www.wikidata.org/entity/Q42575484

about

Cystic Fibrosis: Lessons from the Sweat Gland Deletion of Phe508 in the first nucleotide-binding domain of the cystic fibrosis transmembrane conductance regulator increases its affinity for the heat shock cognate 70 chaperone TMEM16A(a)/anoctamin-1 shares a homodimeric architecture with CLC chloride channels The ABC protein turned chloride channel whose failure causes cystic fibrosis CFTR gating II: Effects of nucleotide binding on the stability of open states The Nucleotide-Binding Sites of SUR1: A Mechanistic Model Molecular action of sulphonylureas on KATP channels: a real partnership between drugs and nucleotides Neuroprotective role of ATP-sensitive potassium channels in cerebral ischemia Integrated analysis of residue coevolution and protein structure in ABC transporters Structures of a minimal human CFTR first nucleotide-binding domain as a monomer, head-to-tail homodimer, and pathogenic mutant ABC ATPase signature helices in Rad50 link nucleotide state to Mre11 interface for DNA repair.Snapshots of the maltose transporter during ATP hydrolysis The Cystic Fibrosis Transmembrane Conductance Regulator (CFTR): THREE-DIMENSIONAL STRUCTURE AND LOCALIZATION OF A CHANNEL GATE Kinetics of the Association/Dissociation Cycle of an ATP-binding Cassette Nucleotide-binding Domain Requirements for Efficient Correction of ΔF508 CFTR Revealed by Analyses of Evolved Sequences EttA regulates translation by binding the ribosomal E site and restricting ribosome-tRNA dynamics The ABC-F protein EttA gates ribosome entry into the translation elongation cycle Domain and nucleotide dependence of the interaction between Saccharomyces cerevisiae translation elongation factors 3 and 1A.Cystic fibrosis transmembrane conductance regulator modulators in cystic fibrosis: current perspectives The proposed channel-enzyme transient receptor potential melastatin 2 does not possess ADP ribose hydrolase activity The primary folding defect and rescue of ΔF508 CFTR emerge during translation of the mutant domain Allosteric coupling between the intracellular coupling helix 4 and regulatory sites of the first nucleotide-binding domain of CFTR Robust Stimulation of W1282X-CFTR Channel Activity by a Combination of Allosteric Modulators Tetrameric structure of SUR2B revealed by electron microscopy of oriented single particles The silent codon change I507-ATC->ATT contributes to the severity of the ΔF508 CFTR channel dysfunction Obligate coupling of CFTR pore opening to tight nucleotide-binding domain dimerization Curcumin and genistein: the combined effects on disease-associated CFTR mutants and their clinical implications Determination of the quaternary structure of a bacterial ATP-binding cassette (ABC) transporter in living cells Impact of the F508del mutation on ovine CFTR, a Cl- channel with enhanced conductance and ATP-dependent gating.The cystic fibrosis transmembrane conductance regulator (CFTR) and its stability Stabilization of Nucleotide Binding Domain Dimers Rescues ABCC6 Mutants Associated with Pseudoxanthoma Elasticum.Development of CFTR Structure ATP and AMP mutually influence their interaction with the ATP-binding cassette (ABC) adenylate kinase cystic fibrosis transmembrane conductance regulator (CFTR) at separate binding sites.Small molecule correctors of F508del-CFTR discovered by structure-based virtual screening Folding and rescue of a cystic fibrosis transmembrane conductance regulator trafficking mutant identified using human-murine chimeric proteins CFTR and TNR-CFTR expression and function in the kidney.Cystic fibrosis: exploiting its genetic basis in the hunt for new therapies Strict coupling between CFTR's catalytic cycle and gating of its Cl- ion pore revealed by distributions of open channel burst durations.ATP-independent CFTR channel gating and allosteric modulation by phosphorylation.The H-loop in the second nucleotide-binding domain of the cystic fibrosis transmembrane conductance regulator is required for efficient chloride channel closing

P2860

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P2860

CFTR channel opening by ATP-driven tight dimerization of its nucleotide-binding domains.

http://www.wikidata.org/entity/Q42575484

description

2005 nî lūn-bûn

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2005年の論文

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2005年論文

@yue

2005年論文

@zh-hant

2005年論文

@zh-hk

2005年論文

@zh-mo

2005年論文

@zh-tw

2005年论文

@wuu

2005年论文

@zh

2005年论文

@zh-cn

name

CFTR channel opening by ATP-driven tight dimerization of its nucleotide-binding domains.

@en

CFTR channel opening by ATP-driven tight dimerization of its nucleotide-binding domains.

@nl

type

label

CFTR channel opening by ATP-driven tight dimerization of its nucleotide-binding domains.

@en

CFTR channel opening by ATP-driven tight dimerization of its nucleotide-binding domains.

@nl

prefLabel

CFTR channel opening by ATP-driven tight dimerization of its nucleotide-binding domains.

@en

CFTR channel opening by ATP-driven tight dimerization of its nucleotide-binding domains.

@nl

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CFTR channel opening by ATP-driven tight dimerization of its nucleotide-binding domains.

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David C Gadsby

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Steve W Lockless

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P2860

Enzyme-Catalyzed Phosphoryl Transfer Reactions

ATP binding to the motor domain from an ABC transporter drives formation of a nucleotide sandwich dimer

Cooperative, ATP-dependent association of the nucleotide binding cassettes during the catalytic cycle of ATP-binding cassette transporters

Structural biology of Rad50 ATPase: ATP-driven conformational control in DNA double-strand break repair and the ABC-ATPase superfamily

The E. coli BtuCD structure: a framework for ABC transporter architecture and mechanism

Crystal structures of the ATPase subunit of the glucose ABC transporter from Sulfolobus solfataricus: nucleotide-free and nucleotide-bound conformations

A tweezers-like motion of the ATP-binding cassette dimer in an ABC transport cycle

Formation of the productive ATP-Mg2+-bound dimer of GlcV, an ABC-ATPase from Sulfolobus solfataricus

Crystal structure of the ATP-binding subunit of an ABC transporter

The ATP hydrolysis cycle of the nucleotide-binding domain of the mitochondrial ATP-binding cassette transporter Mdl1p.

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876-880

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scholarly article

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10.1038/NATURE03313

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7028

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433

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15729345

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2756053

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