Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53
about
Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX proteinTurning the RING domain protein MdmX into an active ubiquitin-protein ligasePhosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCF(beta-TRCP) ubiquitin ligaseRegulation of p53 stability and function by the deubiquitinating enzyme USP42Positive regulation of p53 stability and activity by the deubiquitinating enzyme Otubain 1Mdm2 and mdmX prevent ASPP1 and ASPP2 from stimulating p53 without targeting p53 for degradationRegulation of Rap2A by the ubiquitin ligase Nedd4-1 controls neurite developmentRFWD3-Mdm2 ubiquitin ligase complex positively regulates p53 stability in response to DNA damageMdm4 (Mdmx) regulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development.MDM4 (MDMX) overexpression enhances stabilization of stress-induced p53 and promotes apoptosisNegative regulation of p53 functions by Daxx and the involvement of MDM2Regulation of MDMX nuclear import and degradation by Chk2 and 14-3-3.14-3-3gamma binds to MDMX that is phosphorylated by UV-activated Chk1, resulting in p53 activationAnti-apoptotic protein TCTP controls the stability of the tumor suppressor p53Acetylation is indispensable for p53 activationFBXO11 promotes the Neddylation of p53 and inhibits its transcriptional activityp53 Stabilization and accumulation induced by human vaccinia-related kinase 1Identification and characterization of two novel isoforms of Pirh2 ubiquitin ligase that negatively regulate p53 independent of RING finger domainsProteasome activator PA28 gamma regulates p53 by enhancing its MDM2-mediated degradationA novel ARF-binding protein (LZAP) alters ARF regulation of HDM2Repression of p53-mediated transcription by MDM2: a dual mechanismMdmX is a substrate for the deubiquitinating enzyme USP2aMutational analysis reveals a dual role of Mdm2 acidic domain in the regulation of p53 stabilityA newly identified Pirh2 substrate SCYL1-BP1 can bind to MDM2 and accelerate MDM2 self-ubiquitinationMDM4 (MDMX) localizes at the mitochondria and facilitates the p53-mediated intrinsic-apoptotic pathwayHIPK2 neutralizes MDM2 inhibition rescuing p53 transcriptional activity and apoptotic functionTrim24 targets endogenous p53 for degradationThe Mdm2 oncoprotein interacts with the cell fate regulator NumbMDM2-HDAC1-mediated deacetylation of p53 is required for its degradationDNA damage induces MDMX nuclear translocation by p53-dependent and -independent mechanisms.Targeting of C-terminal binding protein (CtBP) by ARF results in p53-independent apoptosis.p53 downregulates its activating vaccinia-related kinase 1, forming a new autoregulatory loopMDM2 suppresses p73 function without promoting p73 degradationMDMX: a novel p53-binding protein with some functional properties of MDM2Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibitionVisualization and targeted disruption of protein interactions in living cellsp53-independent functions of the p19(ARF) tumor suppressorA TSG101/MDM2 regulatory loop modulates MDM2 degradation and MDM2/p53 feedback controlThe first 30 years of p53: growing ever more complexRibosomal protein L11 negatively regulates oncoprotein MDM2 and mediates a p53-dependent ribosomal-stress checkpoint pathway
P2860
Q22010970-1728BAA8-2000-49A1-A126-1A2BC50B3EC3Q24295055-068A3D3D-9004-4127-8D07-B3D3DBB194A8Q24295177-45B0DFF8-FE50-404F-92AE-C6361C42F6E9Q24297440-81491B9C-B74A-464F-90A9-06604AF45A44Q24298615-DA79A615-7D33-44A7-9DA9-706428657515Q24298622-C2027630-3A4C-46B8-A1D7-602DC44D8184Q24299364-FDCC4586-BDEA-4F3F-83EC-B8C0829F5209Q24300412-BAD16439-574A-4CEE-80FE-1BAF2615EA44Q24300985-39DFECC5-FEB8-4353-997A-C7FBA7779C8FQ24301309-894FA96F-7DBA-4ED1-BF97-48B92735DA4DQ24303893-0D74A69D-0CAF-4230-A518-9152D53A1996Q24306287-73383337-FC7D-4F48-9FAD-66AAF28FFF38Q24306380-F9C4E303-80C8-4D40-8C65-54D6037D6969Q24307469-B3CAB40B-75EE-44DB-A0B5-F6C79ED82A43Q24313477-25B51A98-2B91-42F8-B4B3-719F9337E34AQ24314409-DF8018BE-F372-4950-A42D-EEBC52D4B98FQ24314772-95608F85-C70A-49BE-85A3-2B86B95C6218Q24315623-FDA19AD3-6AD6-4A1A-A2BC-45E2B6960C5FQ24319027-557199AC-D6FC-45C5-8647-E5605B415C40Q24328749-F74617B6-AC54-4DAD-9650-DE665C12F43CQ24336020-B6DD7D81-4B99-477B-8387-B635D7E27BF7Q24336863-E8111D14-1404-4C4F-B884-0DFBDBF3A74AQ24337178-E56343C8-7B9C-4EFC-B121-3CBAAFF80CA8Q24337268-304DBE8C-FFDD-4651-BBBC-EA350ACC10A7Q24337839-0AEF3224-7F9B-4A5B-95CE-FC12058D71C1Q24338503-B6482F3E-95D9-4E68-8FA7-578D6C91E770Q24339423-DFA8F3B4-BA20-4603-A889-BFE64C300B5AQ24522545-479DEEA8-1EB1-4500-A446-C8097465A9E2Q24537700-86F40D7E-D4D5-4E02-B6B7-682A4E1AB5D9Q24540261-B07902BB-5278-4ACF-B81D-BBD862B28D4EQ24548025-F164FDE3-C41B-463A-B6DE-F595F72C8435Q24548984-E83F0D7F-16E6-46F4-94EB-E6840B39B114Q24554510-D721085E-F313-4161-A94B-9D96A3F9C6A4Q24561971-63FA116A-357E-496E-877D-66528E5ECF6FQ24562892-E7A78DFE-A1F5-4FD1-A211-22C0B927B780Q24599716-47203223-20B3-4008-A177-F529614D430AQ24600863-2BEF7B17-36A7-459A-8EA7-E5EE2620BF38Q24621472-40731FA0-D24B-41C5-9A62-EA927DE78111Q24645732-2EDCAE58-7C08-418C-8F39-BA659C9CD7BEQ24648370-0DA01D61-C07F-4592-AB32-923391161B72
P2860
Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53
description
1995 nî lūn-bûn
@nan
1995 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
name
Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53
@ast
Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53
@en
type
label
Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53
@ast
Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53
@en
prefLabel
Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53
@ast
Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53
@en
P2093
P3181
P356
P1433
P1476
Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53
@en
P2093
Montes de Oca Luna R
P2888
P3181
P356
10.1038/378203A0
P407
P577
1995-11-09T00:00:00Z
P6179
1015059358