Hydrogen exchange mass spectrometry reveals protein interfaces and distant dynamic coupling effects during the reversible self-association of an IgG1 monoclonal antibody.
about
Label-Free, In-Solution Screening of Peptide Libraries for Binding to Protein Targets Using Hydrogen Exchange Mass Spectrometry.A new approach to quantification of mAb aggregates using peptide affinity probes.Adaptability of protein structures to enable functional interactions and evolutionary implications.Cutting-edge mass spectrometry methods for the multi-level structural characterization of antibody-drug conjugates.Characterization of Aggregation Propensity of a Human Fc-Fusion Protein Therapeutic by Hydrogen/Deuterium Exchange Mass Spectrometry.Engineering the surface properties of a human monoclonal antibody prevents self-association and rapid clearance in vivo.Mitigation of reversible self-association and viscosity in a human IgG1 monoclonal antibody by rational, structure-guided Fv engineeringCharge-mediated Fab-Fc interactions in an IgG1 antibody induce reversible self-association, cluster formation, and elevated viscosity.Conformational Analysis of Proteins in Highly Concentrated Solutions by Dialysis-Coupled Hydrogen/Deuterium Exchange Mass Spectrometry.
P2860
Q35887956-01D1C903-FE0E-4D36-8BD6-5126E73A05B2Q36276715-6B726A64-3EF9-4F04-9E2B-DE133416F9AFQ38562942-1DBA5816-1696-414E-AA74-A100486F2975Q38665164-56BC3F58-B696-4780-BFF5-2EEAF65FEB07Q39488460-4379E361-5A80-4773-A701-D1C0D6F498B7Q39496098-5F3BDD11-2D25-4EA6-B4A7-800E3BEE2F46Q42083252-62E05DD4-4D0D-45ED-987C-4D8B50209179Q42129206-0779F4B0-2740-4FB2-9053-2A85DC2A8BAEQ51739172-104C239B-615C-457A-A529-06C32F7441B5
P2860
Hydrogen exchange mass spectrometry reveals protein interfaces and distant dynamic coupling effects during the reversible self-association of an IgG1 monoclonal antibody.
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
Hydrogen exchange mass spectro ...... f an IgG1 monoclonal antibody.
@en
Hydrogen exchange mass spectro ...... f an IgG1 monoclonal antibody.
@nl
type
label
Hydrogen exchange mass spectro ...... f an IgG1 monoclonal antibody.
@en
Hydrogen exchange mass spectro ...... f an IgG1 monoclonal antibody.
@nl
prefLabel
Hydrogen exchange mass spectro ...... f an IgG1 monoclonal antibody.
@en
Hydrogen exchange mass spectro ...... f an IgG1 monoclonal antibody.
@nl
P2093
P2860
P1476
Hydrogen exchange mass spectro ...... f an IgG1 monoclonal antibody.
@en
P2093
C Russell Middaugh
David B Volkin
Hardeep S Samra
John M Hickey
Ranajoy Majumdar
Reza Esfandiary
Steven M Bishop
P2860
P304
P356
10.1080/19420862.2015.1029217
P577
2015-01-01T00:00:00Z