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Drugging MYCN through an allosteric transition in Aurora kinase ARevealing Atomic-Level Mechanisms of Protein Allostery with Molecular Dynamics SimulationsProtein Folding and Mechanisms of ProteostasisStructural and physico-chemical effects of disease and non-disease nsSNPs on proteinsPrinciples of allosteric interactions in cell signalingExploring the role of receptor flexibility in structure-based drug discoveryThe Key Role of Calmodulin in KRAS-Driven AdenocarcinomasEffect of CDR3 Sequences and Distal V Gene Residues in Regulating TCR-MHC Contacts and Ligand SpecificityA novel allosteric mechanism in the cysteine peptidase cathepsin K discovered by computational methodsGeomfinder: a multi-feature identifier of similar three-dimensional protein patterns: a ligand-independent approachDynamics-Driven Allostery in Protein KinasesNonlinear backbone torsional pair correlations in proteinsA unified view of "how allostery works"Probing the activity modification space of the cysteine peptidase cathepsin K with novel allosteric modifiersThe SH2 domain regulates c-Abl kinase activation by a cyclin-like mechanism and remodulation of the hinge motionRigid Residue Scan Simulations Systematically Reveal Residue Entropic Roles in Protein AllosteryQuantitative Determination of Flexible Pharmacological Mechanisms Based On Topological Variation in Mice Anti-Ischemic Modular NetworksAllostery: An Overview of Its History, Concepts, Methods, and ApplicationsNMR Characterization of Information Flow and Allosteric Communities in the MAP Kinase p38γMolecular dynamics study on folding and allostery in RfaH.HSPA8/HSC70 chaperone protein: structure, function, and chemical targeting.Emerging Computational Methods for the Rational Discovery of Allosteric Drugs.Computational modeling of allosteric regulation in the hsp90 chaperones: a statistical ensemble analysis of protein structure networks and allosteric communications.Integrating atomistic molecular dynamics simulations, experiments, and network analysis to study protein dynamics: strength in unity.Detection of secondary binding sites in proteins using fragment screeningMutations in Antibody Fragments Modulate Allosteric Response Via Hydrogen-Bond Network Fluctuations.DNA-binding protects p53 from interactions with cofactors involved in transcription-independent functions.Predicting Protein Dynamics and Allostery Using Multi-Protein Atomic Distance Constraints.Molecular and Cellular Therapies: New challenges and opportunities.Designing allostery-inspired response in mechanical networksAllosteric cross-talk in chromatin can mediate drug-drug synergy.From mysteries to medicines: drug development for fibrodysplasia ossificans progressiveTerahertz optical measurements of correlated motions with possible allosteric function.Disordered allostery: lessons from glucocorticoid receptor.Structure-based dynamic arrays in regulatory domains of sodium-calcium exchanger (NCX) isoforms.Structural pathways of cytokines may illuminate their roles in regulation of cancer development and immunotherapy.Detecting Allosteric Networks Using Molecular Dynamics SimulationPossible mechanism and clinical potentials of allostery.The structural basis of ATP as an allosteric modulatorBiophysics of protein evolution and evolutionary protein biophysics
P2860
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P2860
description
2013 nî lūn-bûn
@nan
2013 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Allostery in disease and in drug discovery
@ast
Allostery in disease and in drug discovery
@en
Allostery in disease and in drug discovery
@nl
type
label
Allostery in disease and in drug discovery
@ast
Allostery in disease and in drug discovery
@en
Allostery in disease and in drug discovery
@nl
prefLabel
Allostery in disease and in drug discovery
@ast
Allostery in disease and in drug discovery
@en
Allostery in disease and in drug discovery
@nl
P3181
P1433
P1476
Allostery in disease and in drug discovery
@en
P2093
Chung-Jung Tsai
P304
P3181
P356
10.1016/J.CELL.2013.03.034
P407
P577
2013-04-11T00:00:00Z