Channel gating of the glycine receptor changes accessibility to residues implicated in receptor potentiation by alcohols and anesthetics.
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Potentiation of Gamma Aminobutyric Acid Receptors (GABAAR) by Ethanol: How Are Inhibitory Receptors Affected?The molecular pharmacology of volatile anestheticsGap junctionsThe Role of Multiple Hydrogen-Bonding Groups in Specific Alcohol Binding Sites in Proteins: Insights from Structural Studies of LUSHZinc-dependent modulation of α2- and α3-glycine receptor subunits by ethanol.Ethanol effects on glycinergic transmission: From molecular pharmacology to behavior responsesMutations M287L and Q266I in the glycine receptor α1 subunit change sensitivity to volatile anesthetics in oocytes and neurons, but not the minimal alveolar concentration in knockin miceZinc enhances ethanol modulation of the alpha1 glycine receptor.Molecular targets and mechanisms for ethanol action in glycine receptorsTheoretical studies of the M2 transmembrane segment of the glycine receptor: models of the open pore structure and current-voltage characteristics.A transmembrane amino acid in the GABAA receptor β2 subunit critical for the actions of alcohols and anesthetics.Linking of Glycine Receptor Transmembrane Segments Three and Four Allows Assignment of Intrasubunit-Facing Residues.Microsecond simulations indicate that ethanol binds between subunits and could stabilize an open-state model of a glycine receptor.A Single phenylalanine residue in the main intracellular loop of α1 γ-aminobutyric acid type A and glycine receptors influences their sensitivity to propofol.Modulating inhibitory ligand-gated ion channels.Cross-linking of sites involved with alcohol action between transmembrane segments 1 and 3 of the glycine receptor following activationExperimental determination of the vertical alignment between the second and third transmembrane segments of muscle nicotinic acetylcholine receptorsInter- and Intra-Subunit Butanol/Isoflurane Sites of Action in the Human Glycine Receptor.Ethanol's molecular targetsSingle-channel analysis of ethanol enhancement of glycine receptor functionThe structural basis of function in Cys-loop receptors.Alcohol-binding sites in distinct brain proteins: the quest for atomic level resolution.Effects of amino acid substitutions in transmembrane domains of the NR1 subunit on the ethanol inhibition of recombinant N-methyl-D-aspartate receptors.Computational prediction of ion permeation characteristics in the glycine receptor modified by photo-sensitive compoundsFunctional consequences of mutations in the Drosophila histamine receptor HCLB.Functional and structural analysis of the GABAA receptor alpha 1 subunit during channel gating and alcohol modulation.Occupancy of a single anesthetic binding pocket is sufficient to enhance glycine receptor function.Sites in TM2 and 3 are critical for alcohol-induced conformational changes in GABA receptors.Conformational variability of the glycine receptor M2 domain in response to activation by different agonists.Evidence that ethanol acts on a target in Loop 2 of the extracellular domain of alpha1 glycine receptors.The Glycine Receptor-A Functionally Important Primary Brain Target of Ethanol.
P2860
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P2860
Channel gating of the glycine receptor changes accessibility to residues implicated in receptor potentiation by alcohols and anesthetics.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Channel gating of the glycine ...... n by alcohols and anesthetics.
@en
Channel gating of the glycine ...... n by alcohols and anesthetics.
@nl
type
label
Channel gating of the glycine ...... n by alcohols and anesthetics.
@en
Channel gating of the glycine ...... n by alcohols and anesthetics.
@nl
prefLabel
Channel gating of the glycine ...... n by alcohols and anesthetics.
@en
Channel gating of the glycine ...... n by alcohols and anesthetics.
@nl
P2093
P2860
P356
P1476
Channel gating of the glycine ...... n by alcohols and anesthetics.
@en
P2093
Ingrid A Lobo
James R Trudell
Maria Paola Mascia
R Adron Harris
P2860
P304
33919-33927
P356
10.1074/JBC.M313941200
P407
P577
2004-05-28T00:00:00Z