Different residues in the GABA(A) receptor alpha 1T60-alpha 1K70 region mediate GABA and SR-95531 actions.
about
A unified model of the GABA(A) receptor comprising agonist and benzodiazepine binding sites5-HT3 receptorsIonotropic GABA receptor antagonism-induced adverse outcome pathways for potential neurotoxicity biomarkersMapping the rho1 GABA(C) receptor agonist binding pocket. Constructing a complete modelPhoto-antagonism of the GABAA receptor.New insights into the GABA(A) receptor structure and orthosteric ligand binding: receptor modeling guided by experimental data.Four amino acids in the alpha subunits determine the gamma-aminobutyric acid sensitivities of GABAA receptor subtypes.Allosteric modulators induce distinct movements at the GABA-binding site interface of the GABA-A receptor.Pharmacology of structural changes at the GABA(A) receptor transmitter binding site.Chronic NGF treatment of rat nociceptive DRG neurons in culture facilitates desensitization and deactivation of GABAA receptor-mediated currents.Three arginines in the GABAA receptor binding pocket have distinct roles in the formation and stability of agonist- versus antagonist-bound complexesA tight coupling between β₂Y97 and β₂F200 of the GABA(A) receptor mediates GABA bindingStructural link between γ-aminobutyric acid type A (GABAA) receptor agonist binding site and inner β-sheet governs channel activation and allosteric drug modulationMultiple Tyrosine Residues Contribute to GABA Binding in the GABA(C) Receptor Binding Pocket.Structurally diverse GABA antagonists interact differently with open and closed conformational states of the ρ1 receptor.Synthesis of GABAA receptor agonists and evaluation of their alpha-subunit selectivity and orientation in the GABA binding siteUnnatural amino acid mutagenesis of the GABA(A) receptor binding site residues reveals a novel cation-pi interaction between GABA and beta 2Tyr97Competitive antagonists facilitate the recovery from desensitization of α1β2γ2 GABAA receptors expressed in Xenopus oocytesStructural rearrangements in loop F of the GABA receptor signal ligand binding, not channel activation.Distinct structural changes in the GABAA receptor elicited by pentobarbital and GABA.Structural models of ligand-gated ion channels: sites of action for anesthetics and ethanol.Gamma-aminobutyric acid (GABA) and pentobarbital induce different conformational rearrangements in the GABA A receptor alpha1 and beta2 pre-M1 regions.Methylene blue inhibits GABAA receptors by interaction with GABA binding site.A role for loop G in the β1 strand in GABAA receptor activation.Locating the carboxylate group of GABA in the homomeric rho GABA(A) receptor ligand-binding pocket.Molecular basis for modulation of recombinant alpha1beta2gamma2 GABAA receptors by protons.Molecular dynamics simulations of GABA binding to the GABAC receptor: the role of Arg104.The GABAA receptor alpha 1 subunit Pro174-Asp191 segment is involved in GABA binding and channel gating.Experimental early-life febrile seizures induce changes in GABA(A) R-mediated neurotransmission in the dentate gyrus.Loop G in the GABAA receptor α1 subunit influences gating efficacy.
P2860
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P2860
Different residues in the GABA(A) receptor alpha 1T60-alpha 1K70 region mediate GABA and SR-95531 actions.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh-hant
name
Different residues in the GABA
@nl
Different residues in the GABA ...... ate GABA and SR-95531 actions.
@en
type
label
Different residues in the GABA
@nl
Different residues in the GABA ...... ate GABA and SR-95531 actions.
@en
prefLabel
Different residues in the GABA
@nl
Different residues in the GABA ...... ate GABA and SR-95531 actions.
@en
P2860
P356
P1476
Different residues in the GABA ...... ate GABA and SR-95531 actions.
@en
P2093
Cynthia Czajkowski
Jessica H Holden
P2860
P304
18785-18792
P356
10.1074/JBC.M111778200
P407
P577
2002-03-14T00:00:00Z