Fusion of ETV6 to fibroblast growth factor receptor 3 in peripheral T-cell lymphoma with a t(4;12)(p16;p13) chromosomal translocation.
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Targeting RTK Signaling Pathways in CancerFibroblast growth factor receptor signaling in hereditary and neoplastic disease: biologic and clinical implicationsFunctional roles of fibroblast growth factor receptors (FGFRs) signaling in human cancersBeyond VEGF: inhibition of the fibroblast growth factor pathway and antiangiogenesisIdentification of targetable FGFR gene fusions in diverse cancers.Mutations in the SAM domain of the ETV6-NTRK3 chimeric tyrosine kinase block polymerization and transformation activity.Dependence receptor TrkC is a putative colon cancer tumor suppressor.The Fibroblast Growth Factor signaling pathwayp90RSK2 is essential for FLT3-ITD- but dispensable for BCR-ABL-induced myeloid leukemia.Fibroblast growth factor receptor 1 promotes MG63 cell proliferation and is associated with increased expression of cyclin-dependent kinase 1 in osteosarcomaFGFR inhibitors: Effects on cancer cells, tumor microenvironment and whole-body homeostasis (Review).Translocations in epithelial cancers.Tumour formation by single fibroblast growth factor receptor 3-positive rhabdomyosarcoma-initiating cellsTyrosine kinase gene rearrangements in epithelial malignancies.FGFR3 activates RSK2 to mediate hematopoietic transformation through tyrosine phosphorylation of RSK2 and activation of the MEK/ERK pathway.The small molecule tyrosine kinase inhibitor AMN107 inhibits TEL-PDGFRbeta and FIP1L1-PDGFRalpha in vitro and in vivo.Fibroblast growth factor receptor 3 associates with and tyrosine phosphorylates p90 RSK2, leading to RSK2 activation that mediates hematopoietic transformation.Mutation of the salt bridge-forming residues in the ETV6-SAM domain interface blocks ETV6-NTRK3-induced cellular transformation.Constitutively activated FGFR3 mutants signal through PLCgamma-dependent and -independent pathways for hematopoietic transformation.Identification and characterization of renal cell carcinoma gene markers.FGF Family: From Drug Development to Clinical Application
P2860
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P2860
Fusion of ETV6 to fibroblast growth factor receptor 3 in peripheral T-cell lymphoma with a t(4;12)(p16;p13) chromosomal translocation.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
2001年论文
@zh
2001年论文
@zh-cn
name
Fusion of ETV6 to fibroblast g ...... heral T-cell lymphoma with a t
@nl
Fusion of ETV6 to fibroblast g ...... 13) chromosomal translocation.
@en
type
label
Fusion of ETV6 to fibroblast g ...... heral T-cell lymphoma with a t
@nl
Fusion of ETV6 to fibroblast g ...... 13) chromosomal translocation.
@en
prefLabel
Fusion of ETV6 to fibroblast g ...... heral T-cell lymphoma with a t
@nl
Fusion of ETV6 to fibroblast g ...... 13) chromosomal translocation.
@en
P2093
P1433
P1476
Fusion of ETV6 to fibroblast g ...... p13) chromosomal translocation
@en
P2093
Murohashi I
Taniwaki M
Yagasaki F
Yokoyama Y
P304
P407
P577
2001-12-01T00:00:00Z