Evolution of somatic hypermutation and gene conversion in adaptive immunity.
about
DNA polymerase iota and related rad30-like enzymespoliota, a remarkably error-prone human DNA polymeraseSomatic hypermutation in MutS homologue (MSH)3-, MSH6-, and MSH3/MSH6-deficient mice reveals a role for the MSH2-MSH6 heterodimer in modulating the base substitution patternExtensive analysis of D-J-C arrangements allows the identification of different mechanisms enhancing the diversity in sheep T cell receptor beta-chain repertoire.A new class of errant DNA polymerases provides candidates for somatic hypermutation.Adaptive translation as a mechanism of stress response and adaptation.Somatic immunoglobulin hypermutation.In vivo and in vitro studies of immunoglobulin gene somatic hypermutation.Evolution and the molecular basis of somatic hypermutation of antigen receptor genes.Comparative analyses of immunoglobulin genes: surprises and portents.Immunoglobulin somatic hypermutation: double-strand DNA breaks, AID and error-prone DNA repair.Known components of the immunoglobulin A:T mutational machinery are intact in Burkitt lymphoma cell lines with G:C biasOn the molecular mechanism of somatic hypermutation of rearranged immunoglobulin genes.Altered Ig hypermutation pattern and frequency in complementary mouse models of DNA polymerase ζ activity.Induction of Ig somatic hypermutation and class switching in a human monoclonal IgM+ IgD+ B cell line in vitro: definition of the requirements and modalities of hypermutation.The translesion DNA polymerase zeta plays a major role in Ig and bcl-6 somatic hypermutation.Error-prone candidates vie for somatic mutationThe role of DNA repair in somatic hypermutation of immunoglobulin genes.Expression of error-prone polymerases in BL2 cells activated for Ig somatic hypermutation.Somatic hypermutation of the new antigen receptor gene (NAR) in the nurse shark does not generate the repertoire: possible role in antigen-driven reactions in the absence of germinal centersAnalysis of somatic hypermutation in X-linked hyper-IgM syndrome shows specific deficiencies in mutational targeting.The intrinsic hypermutability of antibody heavy and light chain genes decays exponentially.DNA polymerase mu (Pol mu), homologous to TdT, could act as a DNA mutator in eukaryotic cells.Sequence similarities of protein kinase peptide substrates and inhibitors: comparison of their primary structures with immunoglobulin repeats.Coevolution of quasispecies: B-cell mutation rates maximize viral error catastrophes.Analyzing Immunoglobulin Repertoires.Class switch recombination of the chicken IgH chain genes: implications for the primordial switch region repeats.
P2860
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P2860
Evolution of somatic hypermutation and gene conversion in adaptive immunity.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
1998年论文
@zh
1998年论文
@zh-cn
name
Evolution of somatic hypermutation and gene conversion in adaptive immunity.
@en
Evolution of somatic hypermutation and gene conversion in adaptive immunity.
@nl
type
label
Evolution of somatic hypermutation and gene conversion in adaptive immunity.
@en
Evolution of somatic hypermutation and gene conversion in adaptive immunity.
@nl
prefLabel
Evolution of somatic hypermutation and gene conversion in adaptive immunity.
@en
Evolution of somatic hypermutation and gene conversion in adaptive immunity.
@nl
P2860
P1476
Evolution of somatic hypermutation and gene conversion in adaptive immunity.
@en
P2093
P2860
P356
10.1111/J.1600-065X.1998.TB01425.X
P577
1998-04-01T00:00:00Z