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The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblastsTDP2-dependent non-homologous end-joining protects against topoisomerase II-induced DNA breaks and genome instability in cells and in vivoMice lacking Dfna5 show a diverging number of cochlear fourth row outer hair cellsInactivation of Smad5 in endothelial cells and smooth muscle cells demonstrates that Smad5 is required for cardiac homeostasisSmad5 is dispensable for adult murine hematopoiesis.Zeb2 Regulates Cell Fate at the Exit from Epiblast State in Mouse Embryonic Stem CellsBMP-SMAD signalling output is highly regionalized in cardiovascular and lymphatic endothelial networks.TDP2 promotes repair of topoisomerase I-mediated DNA damage in the absence of TDP1.Conditional deletion of Smad1 and Smad5 in somatic cells of male and female gonads leads to metastatic tumor development in mice.Smad1/5/8 are myogenic regulators of murine and human mesoangioblastsBMP-SMAD Signaling Regulates Lineage Priming, but Is Dispensable for Self-Renewal in Mouse Embryonic Stem CellsThyroid follicle development requires Smad1/5- and endothelial cell-dependent basement membrane assemblyFunctions of the type 1 BMP receptor Acvr1 (Alk2) in lens development: cell proliferation, terminal differentiation, and survivalFGF-regulated BMP signaling is required for eyelid closure and to specify conjunctival epithelial cell fate.A broken heart: a stretch too far: an overview of mouse models with mutations in stretch-sensor components.The type I BMP receptors, Bmpr1a and Acvr1, activate multiple signaling pathways to regulate lens formationTransforming Growth Factor type beta and Smad family signaling in stem cell function.Few Smad proteins and many Smad-interacting proteins yield multiple functions and action modes in TGFβ/BMP signaling in vivo.Robustness in angiogenesis: notch and BMP shaping waves.Smad1/5 is required for erythropoietin-mediated suppression of hepcidin in mice.Antagonism of Nodal signaling by BMP/Smad5 prevents ectopic primitive streak formation in the mouse amnion.Essential validation of gene trap mouse ES cell lines: a test case with the gene Ttrap.Smad1/5 and Smad4 expression are important for osteoclast differentiation.Stalk cell phenotype depends on integration of Notch and Smad1/5 signaling cascades.Smad1 and its target gene Wif1 coordinate BMP and Wnt signaling activities to regulate fetal lung development.Neuronal deficiency of presenilin 1 inhibits amyloid plaque formation and corrects hippocampal long-term potentiation but not a cognitive defect of amyloid precursor protein [V717I] transgenic mice.
P50
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P50
name
Lieve Umans
@ast
Lieve Umans
@en
Lieve Umans
@es
Lieve Umans
@nl
type
label
Lieve Umans
@ast
Lieve Umans
@en
Lieve Umans
@es
Lieve Umans
@nl
prefLabel
Lieve Umans
@ast
Lieve Umans
@en
Lieve Umans
@es
Lieve Umans
@nl