about
TRF2 and apollo cooperate with topoisomerase 2alpha to protect human telomeres from replicative damageNicotinic acetylcholine receptor subtypes in the rat sympathetic ganglion: pharmacological characterization, subcellular distribution and effect of pre- and postganglionic nerve crushTelomere damage induced by the G-quadruplex ligand RHPS4 has an antitumor effectStabilization of quadruplex DNA perturbs telomere replication leading to the activation of an ATR-dependent ATM signaling pathway.SIRT6 interacts with TRF2 and promotes its degradation in response to DNA damage.N-cyclic bay-substituted perylene G-quadruplex ligands have selective antiproliferative effects on cancer cells and induce telomere damage.Identification of novel RHPS4-derivative ligands with improved toxicological profiles and telomere-targeting activitiesTRF2 inhibits a cell-extrinsic pathway through which natural killer cells eliminate cancer cells.Aromatic core extension in the series of N-cyclic bay-substituted perylene G-quadruplex ligands: increased telomere damage, antitumor activity, and strong selectivity for neoplastic over healthy cells.A basal level of DNA damage and telomere deprotection increases the sensitivity of cancer cells to G-quadruplex interactive compounds.AKTIP/Ft1, a New Shelterin-Interacting Factor Required for Telomere MaintenanceIntragenic G-quadruplex structure formed in the human CD133 and its biological and translational relevanceOn and off-target effects of telomere uncapping G-quadruplex selective ligands based on pentacyclic acridinium saltsEvidence for G-quadruplex in the promoter of vegfr-2 and its targeting to inhibit tumor angiogenesis.Methods of studying telomere damage induced by quadruplex-ligand complexes.Hippocampal gene expression is modulated by hypergravity.Perylene and coronene derivatives binding to G-rich promoter oncogene sequences efficiently reduce their expression in cancer cells.Inhibition of PARP activity by PJ-34 leads to growth impairment and cell death associated with aberrant mitotic pattern and nucleolar actin accumulation in M14 melanoma cell line.TRF2 inhibition triggers apoptosis and reduces tumourigenicity of human melanoma cells.PARP1 is activated at telomeres upon G4 stabilization: possible target for telomere-based therapy.Erratum: identification of novel RHPS4-derivative ligands with improved toxicological profiles and telomere-targeting activities.Biological activity of the G-quadruplex ligand RHPS4 (3,11-difluoro-6,8,13-trimethyl-8H-quino[4,3,2-kl]acridinium methosulfate) is associated with telomere capping alteration.G-quadruplex ligand RHPS4 potentiates the antitumor activity of camptothecins in preclinical models of solid tumors.Evidence for G-quadruplex in the promoter of VEGFR-2 and its targeting to inhibit tumor angiogenesis.Shooting for Selective Druglike G-Quadruplex Binders: Evidence for Telomeric DNA Damage and Tumor Cell DeathPharmacological activation of SIRT6 triggers lethal autophagy in human cancer cellsDNA Damage Persistence as Determinant of Tumor Sensitivity to the Combination of Topo I Inhibitors and Telomere-Targeting AgentsEmerging roles of telomeric chromatin alterations in cancerTRF2 positively regulates SULF2 expression increasing VEGF-A release and activity in tumor microenvironment
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P50
description
hulumtuese
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Angela Rizzo
@ast
Angela Rizzo
@en
Angela Rizzo
@es
Angela Rizzo
@nl
type
label
Angela Rizzo
@ast
Angela Rizzo
@en
Angela Rizzo
@es
Angela Rizzo
@nl
prefLabel
Angela Rizzo
@ast
Angela Rizzo
@en
Angela Rizzo
@es
Angela Rizzo
@nl
P106
P21
P31
P496
0000-0001-5421-3085