SOCS-3 is an insulin-induced negative regulator of insulin signaling.
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Insulin resistance in patients with chronic kidney diseaseJAK/STAT3 pathway is involved in survival of neurons in response to insulin-like growth factor and negatively regulated by suppressor of cytokine signaling-3The E3 ubiquitin ligase HOIL-1 induces the polyubiquitination and degradation of SOCS6 associated proteinsGrb10 prevents Nedd4-mediated vascular endothelial growth factor receptor-2 degradationDeletion of SOCS7 leads to enhanced insulin action and enlarged islets of Langerhans.Central role of suppressors of cytokine signaling proteins in hepatic steatosis, insulin resistance, and the metabolic syndrome in the mouseGetting 'Smad' about obesity and diabetesSIRT2 regulates adipocyte differentiation through FoxO1 acetylation/deacetylationSignal transducer and activator of transcription (STAT)-induced STAT inhibitor 1 (SSI-1)/suppressor of cytokine signaling 1 (SOCS1) inhibits insulin signal transduction pathway through modulating insulin receptor substrate 1 (IRS-1) phosphorylationInsulin receptor signaling in normal and insulin-resistant statesCell Biology Symposium: feed efficiency: mitochondrial function to global gene expressionSOCS3: An essential physiological inhibitor of signaling by interleukin-6 and G-CSF family cytokinesThe role of suppressors of cytokine signalling in human neoplasmsImplication of inflammatory signaling pathways in obesity-induced insulin resistancePossible Integrative Actions of Leptin and Insulin Signaling in the Hypothalamus Targeting Energy HomeostasisSuppressors of cytokine signaling-1 and -6 associate with and inhibit the insulin receptor. A potential mechanism for cytokine-mediated insulin resistanceSuppressor of cytokine signaling 1 interacts with the macrophage colony-stimulating factor receptor and negatively regulates its proliferation signalSuppressor of cytokine signaling 6 associates with KIT and regulates KIT receptor signalingDeletion of skeletal muscle SOCS3 prevents insulin resistance in obesityIntravitreal injection of IGFBP-3 restores normal insulin signaling in diabetic rat retinaInsulin regulates SOCS2 expression and the mitogenic effect of IGF-1 in mesangial cellsHIV-protease inhibitors induce expression of suppressor of cytokine signaling-1 in insulin-sensitive tissues and promote insulin resistance and type 2 diabetes mellitusSuppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanismsThe farnesoid X receptor modulates adiposity and peripheral insulin sensitivity in miceSurfing the insulin signaling webRole of the immune system in hypertension: modulation by dietary antioxidants.Activation of SOCS-3 by resistinAsb6, an adipocyte-specific ankyrin and SOCS box protein, interacts with APS to enable recruitment of elongins B and C to the insulin receptor signaling complex.Negative regulation of receptor tyrosine kinase signals.Higher expression levels of SOCS 1,3,4,7 are associated with earlier tumour stage and better clinical outcome in human breast cancer.Expression of ankyrin repeat and suppressor of cytokine signaling box protein 4 (Asb-4) in proopiomelanocortin neurons of the arcuate nucleus of mice produces a hyperphagic, lean phenotypeCellular insulin resistance disrupts leptin-mediated control of neuronal signaling and transcription.Differential effects of cream, glucose, and orange juice on inflammation, endotoxin, and the expression of Toll-like receptor-4 and suppressor of cytokine signaling-3Suppressor of cytokine signaling 3 (SOCS-3) protects beta -cells against interleukin-1beta - and interferon-gamma -mediated toxicityRegulation of Id gene expression by type I insulin-like growth factor: roles of Stat3 and the tyrosine 950 residue of the receptor.Mechanisms for the adverse effects of late gestational increases in maternal cortisol on the heart revealed by transcriptomic analyses of the fetal septumThe role of the cullin-5 e3 ubiquitin ligase in the regulation of insulin receptor substrate-1.Inhibition of insulin receptor catalytic activity by the molecular adapter Grb14.Etanercept restores normal insulin signal transduction in β2-adrenergic receptor knockout mice.Requirement of JIP1-mediated c-Jun N-terminal kinase activation for obesity-induced insulin resistance.
P2860
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P2860
SOCS-3 is an insulin-induced negative regulator of insulin signaling.
description
2000 nî lūn-bûn
@nan
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
2000年论文
@zh
2000年论文
@zh-cn
name
SOCS-3 is an insulin-induced negative regulator of insulin signaling.
@en
SOCS-3 is an insulin-induced negative regulator of insulin signaling.
@nl
type
label
SOCS-3 is an insulin-induced negative regulator of insulin signaling.
@en
SOCS-3 is an insulin-induced negative regulator of insulin signaling.
@nl
prefLabel
SOCS-3 is an insulin-induced negative regulator of insulin signaling.
@en
SOCS-3 is an insulin-induced negative regulator of insulin signaling.
@nl
P2093
P356
P1476
SOCS-3 is an insulin-induced negative regulator of insulin signaling.
@en
P2093
D Sawka-Verhelle
E Van Obberghen
P304
15985-15991
P356
10.1074/JBC.275.21.15985
P407
P577
2000-05-01T00:00:00Z