Selective induction of apoptosis in cancer cells by the ether lipid ET-18-OCH3 (Edelfosine): molecular structure requirements, cellular uptake, and protection by Bcl-2 and Bcl-X(L).
about
Edelfosine-induced metabolic changes in cancer cells that precede the overproduction of reactive oxygen species and apoptosisLipid raft: A floating island of death or survivalInhibition of Granulomatous Inflammation and Prophylactic Treatment of Schistosomiasis with a Combination of Edelfosine and PraziquantelIn vitro and in vivo anti-schistosomal activity of the alkylphospholipid analog edelfosineInvolvement of raft aggregates enriched in Fas/CD95 death-inducing signaling complex in the antileukemic action of edelfosine in Jurkat cellsMultiple mutations in heterogeneous miltefosine-resistant Leishmania major population as determined by whole genome sequencingIn vitro and in vivo efficacy of ether lipid edelfosine against Leishmania spp. and SbV-resistant parasitesThe orally available, synthetic ether lipid edelfosine inhibits T cell proliferation and induces a type I interferon responseHuman TMEM30a promotes uptake of antitumor and bioactive choline phospholipids into mammalian cellsOSU-T315: a novel targeted therapeutic that antagonizes AKT membrane localization and activation of chronic lymphocytic leukemia cellsInduction of apoptosis in human mitogen-activated peripheral blood T-lymphocytes by the ether phospholipid ET-18-OCH3: involvement of the Fas receptor/ligand system.Involvement of lipid rafts in the localization and dysfunction effect of the antitumor ether phospholipid edelfosine in mitochondria.The ether lipid ET-18-OCH3 increases cytosolic Ca2+ concentrations in Madin Darby canine kidney cellsEndoplasmic reticulum targeting in Ewing's sarcoma by the alkylphospholipid analog edelfosineDrug uptake, lipid rafts, and vesicle trafficking modulate resistance to an anticancer lysophosphatidylcholine analogue in yeastEffects of ether vs. ester linkage on lipid bilayer structure and water permeabilityErufosine, a novel alkylphosphocholine, in acute myeloid leukemia: single activity and combination with other antileukemic drugs.Lipid analogues as potential drugs for the regulation of mitochondrial cell death.Glycosidated phospholipids: uncoupling of signalling pathways at the plasma membrane.PI3K and Akt as molecular targets for cancer therapy: current clinical outcomes.Lipids and cell death in yeast.Caenorhabditis elegans as a platform to study the mechanism of action of synthetic antitumor lipidsMitochondria and lipid raft-located FOF1-ATP synthase as major therapeutic targets in the antileishmanial and anticancer activities of ether lipid edelfosine.Resistance to alkyl-lysophospholipid-induced apoptosis due to downregulated sphingomyelin synthase 1 expression with consequent sphingomyelin- and cholesterol-deficiency in lipid rafts.Combination of the anti-tumour cell ether lipid edelfosine with sterols abolishes haemolytic side effects of the drug.Necroptosis is associated with low procaspase-8 and active RIPK1 and -3 in human glioma cells.Alteration of plasma membrane organization by an anticancer lysophosphatidylcholine analogue induces intracellular acidification and internalization of plasma membrane transporters in yeast.Different modes of internalization of apoptotic alkyl-lysophospholipid and cell-rescuing lysophosphatidylcholine.Intracellular triggering of Fas aggregation and recruitment of apoptotic molecules into Fas-enriched rafts in selective tumor cell apoptosisLipid raft-mediated Akt signaling as a therapeutic target in mantle cell lymphomaLipid raft involvement in yeast cell growth and death.Low plasma membrane expression of the miltefosine transport complex renders Leishmania braziliensis refractory to the drug.
P2860
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P2860
Selective induction of apoptosis in cancer cells by the ether lipid ET-18-OCH3 (Edelfosine): molecular structure requirements, cellular uptake, and protection by Bcl-2 and Bcl-X(L).
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
Selective induction of apoptos ...... tection by Bcl-2 and Bcl-X(L).
@en
Selective induction of apoptos ...... tection by Bcl-2 and Bcl-X(L).
@nl
type
label
Selective induction of apoptos ...... tection by Bcl-2 and Bcl-X(L).
@en
Selective induction of apoptos ...... tection by Bcl-2 and Bcl-X(L).
@nl
prefLabel
Selective induction of apoptos ...... tection by Bcl-2 and Bcl-X(L).
@en
Selective induction of apoptos ...... tection by Bcl-2 and Bcl-X(L).
@nl
P2093
P1433
P1476
Selective induction of apoptos ...... otection by Bcl-2 and Bcl-X(L)
@en
P2093
Fernández-Luna JL
Martín-Martín B
Martínez-Dalmau R
Modolell M
Mollinedo F
P304
P407
P577
1997-04-01T00:00:00Z