Requirement for C-terminal sequences in regulation of Ect2 guanine nucleotide exchange specificity and transformation.
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The tandem BRCT domains of Ect2 are required for both negative and positive regulation of Ect2 in cytokinesisEct2 links the PKCiota-Par6alpha complex to Rac1 activation and cellular transformationRho guanine nucleotide exchange factors: regulators of Rho GTPase activity in development and diseaseStructural Basis for Autoinhibition of the Guanine Nucleotide Exchange Factor FARP2Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?Overexpression of the Rho-guanine nucleotide exchange factor ECT2 inhibits nuclear translocation of nuclear receptor CAR in the mouse liverRole of the C-terminal SH3 domain and N-terminal tyrosine phosphorylation in regulation of Tim and related Dbl-family proteinsOpposing roles of p190RhoGAP and Ect2 RhoGEF in regulating cytokinesis.Regulation of the Rac GTPase pathway by the multifunctional Rho GEF Pebble is essential for mesoderm migration in the Drosophila gastrula.The ect2 rho Guanine nucleotide exchange factor is essential for early mouse development and normal cell cytokinesis and migration.Toward understanding RhoGTPase specificity: structure, function and local activation.The guanine nucleotide exchange factor (GEF) Ect2 is an oncogene in human cancer.The dectin 1 agonist curdlan regulates osteoclastogenesis by inhibiting nuclear factor of activated T cells cytoplasmic 1 (NFATc1) through Syk kinase.APC(cdh1) mediates degradation of the oncogenic Rho-GEF Ect2 after mitosis.Transformation by a nucleotide-activated P2Y receptor is mediated by activation of Galphai, Galphaq and Rho-dependent signaling pathways.An anillin-Ect2 complex stabilizes central spindle microtubules at the cortex during cytokinesis.The Sec14 homology domain regulates the cellular distribution and transforming activity of the Rho-specific guanine nucleotide exchange factor Dbs.Deregulation of HEF1 impairs M-phase progression by disrupting the RhoA activation cycle.Oncogenic activity of Ect2 is regulated through protein kinase C iota-mediated phosphorylationUp-regulation of ECT2 is associated with poor prognosis in gastric cancer patients.Cdc42 and the guanine nucleotide exchange factors Ect2 and trio mediate Fn14-induced migration and invasion of glioblastoma cellsRegulation of the actin cytoskeleton by PIP2 in cytokinesis.Mechanisms of CDC-42 activation during contact-induced cell polarizationThe guanine nucleotide exchange factors trio, Ect2, and Vav3 mediate the invasive behavior of glioblastoma.The Role of Ect2 Nuclear RhoGEF Activity in Ovarian Cancer Cell Transformation.Functions and Mechanisms of Fibroblast Growth Factor (FGF) Signalling in Drosophila melanogaster.CUX1 and E2F1 regulate coordinated expression of the mitotic complex genes Ect2, MgcRacGAP, and MKLP1 in S phase.Overexpression of epithelial cell transforming 2 protein in colorectal carcinoma predicts a poor prognosis.Auto-inhibition of the Dbl Family Protein Tim by an N-terminal Helical Motif
P2860
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P2860
Requirement for C-terminal sequences in regulation of Ect2 guanine nucleotide exchange specificity and transformation.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Requirement for C-terminal seq ...... pecificity and transformation.
@en
Requirement for C-terminal seq ...... pecificity and transformation.
@nl
type
label
Requirement for C-terminal seq ...... pecificity and transformation.
@en
Requirement for C-terminal seq ...... pecificity and transformation.
@nl
prefLabel
Requirement for C-terminal seq ...... pecificity and transformation.
@en
Requirement for C-terminal seq ...... pecificity and transformation.
@nl
P2093
P2860
P356
P1476
Requirement for C-terminal seq ...... pecificity and transformation.
@en
P2093
Adrienne D Cox
Channing J Der
Kent L Rossman
Patricia A Solski
Rhonda S Wilder
Sharon L Campbell
P2860
P304
25226-25233
P356
10.1074/JBC.M313792200
P407
P50
P577
2004-04-08T00:00:00Z