MB4-2 breakpoint in MMSET combined with del(17p) defines a subset of t(4;14) multiple myeloma with very poor prognosis.

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MB4-2/MB4-3 transcripts of IGH-MMSET fusion gene in t(4;14)pos multiple myeloma indicate poor prognosis.The effect of novel therapies in high-molecular-risk multiple myeloma.

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MB4-2 breakpoint in MMSET combined with del(17p) defines a subset of t(4;14) multiple myeloma with very poor prognosis.

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2015年論文

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2015年論文

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2015年論文

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MB4-2 breakpoint in MMSET combined with del

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MB4-2 breakpoint in MMSET comb ...... loma with very poor prognosis.

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MB4-2 breakpoint in MMSET combined with del

@nl

MB4-2 breakpoint in MMSET comb ...... loma with very poor prognosis.

@en

prefLabel

MB4-2 breakpoint in MMSET combined with del

@nl

MB4-2 breakpoint in MMSET comb ...... loma with very poor prognosis.

@en

P1476

MB4-2 breakpoint in MMSET comb ...... eloma with very poor prognosis

@en

P2093

Anne Lazareth

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Aurelie Coquin

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Bertrand Arnulf

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Hervé Avet Loiseau

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Jean Christophe Bories

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Jean Paul Fermand

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Jean Soulier

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Karim Belhadj

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Laurent Frenzel

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Lionel Karlin

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Criteria for diagnosis, staging, risk stratification and response assessment of multiple myeloma

Overexpression of transcripts originating from the MMSET locus characterizes all t(4;14)(p16;q32)-positive multiple myeloma patients

The t(4;14) translocation in myeloma dysregulates both FGFR3 and a novel gene, MMSET, resulting in IgH/MMSET hybrid transcripts

MMSET regulates histone H4K20 methylation and 53BP1 accumulation at DNA damage sites

Global chromatin profiling reveals NSD2 mutations in pediatric acute lymphoblastic leukemia.

NSD2 links dimethylation of histone H3 at lysine 36 to oncogenic programming.

Point mutation E1099K in MMSET/NSD2 enhances its methyltranferase activity and leads to altered global chromatin methylation in lymphoid malignancies

The MMSET protein is a histone methyltransferase with characteristics of a transcriptional corepressor

Bortezomib plus dexamethasone induction improves outcome of patients with t(4;14) myeloma but not outcome of patients with del(17p).

Detection and follow-up of fibroblast growth factor receptor 3 expression on bone marrow and circulating plasma cells by flow cytometry in patients with t(4;14) multiple myeloma.

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scholarly article

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10.3324/HAEMATOL.2015.127001

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100

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Sylvie Chevret

Jerome Tamburini

Damien Roos-Weil

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2015-07-23T00:00:00Z

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280327551

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26206803

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MB4-2 breakpoint in MMSET combined with del(17p) defines a subset of t(4;14) multiple myeloma with very poor prognosis.

about

P2860

P2860

MB4-2 breakpoint in MMSET combined with del(17p) defines a subset of t(4;14) multiple myeloma with very poor prognosis.

description

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type

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P1433

P1476

P2093

P2860

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P1476

P2093

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