Acute effect on the Aβ isoform pattern in CSF in response to γ-secretase modulator and inhibitor treatment in dogs.
about
γ-Secretase inhibitors and modulators.BACE1 inhibition induces a specific cerebrospinal fluid β-amyloid pattern that identifies drug effects in the central nervous systemHas inhibition of Aβ production adequately been tested as therapeutic approach in mild AD? A model-based meta-analysis of γ-secretase inhibitor data.Amyloid-β metabolism in Niemann-Pick C disease models and patients.The amyloid-β isoform pattern in cerebrospinal fluid in familial PSEN1 M139T- and L286P-associated Alzheimer's diseaseThe γ-secretase complex: from structure to function.γ-Secretase processing and effects of γ-secretase inhibitors and modulators on long Aβ peptides in cells.First and second generation γ-secretase modulators (GSMs) modulate amyloid-β (Aβ) peptide production through different mechanismsSecond generation γ-secretase modulators exhibit different modulation of Notch β and Aβ production.APLP1 as a cerebrospinal fluid biomarker for γ-secretase modulator treatmentγ-Secretase modulator (GSM) photoaffinity probes reveal distinct allosteric binding sites on presenilin.Young to Middle-Aged Dogs with High Amyloid-β Levels in Cerebrospinal Fluid are Impaired on Learning in Standard Cognition testsNovel γ-secretase modulators: a review of patents from 2008 to 2010.Clinical utility of neuroprotective agents in neurodegenerative diseases: current status of drug development for Alzheimer's, Parkinson's and Huntington's diseases, and amyotrophic lateral sclerosis.Treatment strategies targeting amyloid β-protein.Development and mechanism of γ-secretase modulators for Alzheimer's disease.Novel γ-secretase modulators for the treatment of Alzheimer's disease: a review focusing on patents from 2010 to 2012.Truncated and modified amyloid-beta species.Novel γ-secretase enzyme modulators directly target presenilin protein.Amyloid-β(1-15/16) as a marker for γ-secretase inhibition in Alzheimer's disease.Attenuated Abeta42 responses to low potency gamma-secretase modulators can be overcome for many pathogenic presenilin mutants by second-generation compoundsAlzheimer's disease biomarkers in animal models: closing the translational gap.β-site amyloid precursor protein-cleaving enzyme 1(BACE1) inhibitor treatment induces Aβ5-X peptides through alternative amyloid precursor protein cleavagePhenotypic Screening Identifies Modulators of Amyloid Precursor Protein Processing in Human Stem Cell Models of Alzheimer's Disease.Aβ1-15/16 as a potential diagnostic marker in neurodegenerative diseases.Structural and Chemical Biology of Presenilin Complexes.
P2860
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P2860
Acute effect on the Aβ isoform pattern in CSF in response to γ-secretase modulator and inhibitor treatment in dogs.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
2010年论文
@zh
2010年论文
@zh-cn
name
Acute effect on the Aβ isoform ...... d inhibitor treatment in dogs.
@en
Acute effect on the Aβ isoform ...... d inhibitor treatment in dogs.
@nl
type
label
Acute effect on the Aβ isoform ...... d inhibitor treatment in dogs.
@en
Acute effect on the Aβ isoform ...... d inhibitor treatment in dogs.
@nl
prefLabel
Acute effect on the Aβ isoform ...... d inhibitor treatment in dogs.
@en
Acute effect on the Aβ isoform ...... d inhibitor treatment in dogs.
@nl
P2093
P50
P356
P1476
Acute effect on the Aβ isoform ...... d inhibitor treatment in dogs.
@en
P2093
Bianca Van Broeck
Herman Borghys
Marc Mercken
Mikael K Gustavsson
Ulf Andreasson
P304
P356
10.3233/JAD-2010-100573
P577
2010-01-01T00:00:00Z