An NS3 serine protease inhibitor abrogates replication of subgenomic hepatitis C virus RNA.
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Development of a cell-based high-throughput specificity screen using a hepatitis C virus-bovine viral diarrhea virus dual replicon assay.Inhibitory Effect of 2'-Substituted Nucleosides on Hepatitis C Virus Replication Correlates with Metabolic Properties in Replicon CellsComplete translation of the hepatitis C virus genome in vitro: membranes play a critical role in the maturation of all virus proteins except for NS3.Mutations conferring resistance to a hepatitis C virus (HCV) RNA-dependent RNA polymerase inhibitor alone or in combination with an HCV serine protease inhibitor in vitro.Quantitative Analysis of the Hepatitis C Virus Replication ComplexMathematical Modeling of Subgenomic Hepatitis C Virus Replication in Huh-7 CellsModeling Subgenomic Hepatitis C Virus RNA Kinetics during Treatment with Alpha InterferonPromising candidates for the treatment of chronic hepatitis C.Role for ADP ribosylation factor 1 in the regulation of hepatitis C virus replicationReplication vesicles are load- and choke-points in the hepatitis C virus lifecycle.Quantifying the diversification of hepatitis C virus (HCV) during primary infection: estimates of the in vivo mutation rate.In-vitro antiviral activity of Solanum nigrum against Hepatitis C Virus.Rapid emergence of protease inhibitor resistance in hepatitis C virus.Post-transcriptional inhibition of hepatitis C virus replication through small interference RNA.Current and emerging therapeutic approaches to hepatitis C infection.Host cell targets in HCV therapy: novel strategy or proven practice?Therapeutic potential of RNA interference: a new molecular approach to antiviral treatment for hepatitis C.Highly heterogeneous mutation rates in the hepatitis C virus genome.The hepatitis C virus NS5A inhibitor (BMS-790052) alters the subcellular localization of the NS5A non-structural viral protein.Preclinical characterization of BI 201335, a C-terminal carboxylic acid inhibitor of the hepatitis C virus NS3-NS4A proteaseA glimpse at the future of hepatitis C therapy: the INFORM trial.p21-activated kinase 1 is activated through the mammalian target of rapamycin/p70 S6 kinase pathway and regulates the replication of hepatitis C virus in human hepatoma cells.Binding site characterization and resistance to a class of non-nucleoside inhibitors of the hepatitis C virus NS5B polymerase.Hepatitis C virus subgenomic replicons in the human embryonic kidney 293 cell line.Combination of a hepatitis C virus NS3-NS4A protease inhibitor and alpha interferon synergistically inhibits viral RNA replication and facilitates viral RNA clearance in replicon cells.Inhibition of the subgenomic hepatitis C virus replicon in huh-7 cells by 2'-deoxy-2'-fluorocytidine.Suppression of hepatitis C virus replicon by RNA interference directed against the NS3 and NS5B regions of the viral genome.Specific inhibitors of HCV polymerase identified using an NS5B with lower affinity for template/primer substrate.Sensitivity of NS3 serine proteases from hepatitis C virus genotypes 2 and 3 to the inhibitor BILN 2061.Mathematical model for suppression of subgenomic hepatitis C virus RNA replication in cell culture.HCV NS3/4A Protease Inhibitors and the Road to Effective Direct-Acting Antiviral Therapies
P2860
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P2860
An NS3 serine protease inhibitor abrogates replication of subgenomic hepatitis C virus RNA.
description
2003 nî lūn-bûn
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2003年の論文
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2003年学术文章
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2003年学术文章
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@zh-hans
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name
An NS3 serine protease inhibit ...... genomic hepatitis C virus RNA.
@en
An NS3 serine protease inhibit ...... genomic hepatitis C virus RNA.
@nl
type
label
An NS3 serine protease inhibit ...... genomic hepatitis C virus RNA.
@en
An NS3 serine protease inhibit ...... genomic hepatitis C virus RNA.
@nl
prefLabel
An NS3 serine protease inhibit ...... genomic hepatitis C virus RNA.
@en
An NS3 serine protease inhibit ...... genomic hepatitis C virus RNA.
@nl
P2093
P2860
P356
P1476
An NS3 serine protease inhibit ...... genomic hepatitis C virus RNA.
@en
P2093
Arnim Pause
Charles Pellerin
Daniel Lamarre
Diane Thibeault
Florence Dô
George Kukolj
Ginette McKercher
Lisette Lagacé
Louise Pilote
Martin Marquis
P2860
P304
20374-20380
P356
10.1074/JBC.M210785200
P407
P577
2003-03-19T00:00:00Z