Glycogen synthase kinase 3 inhibition slows mitochondrial adenine nucleotide transport and regulates voltage-dependent anion channel phosphorylation.
about
Mitochondrial Dysfunction in Alzheimer's Disease and the Rationale for Bioenergetics Based TherapiesRegulation of mitochondrial function by voltage dependent anion channels in ethanol metabolism and the Warburg effectRole of the MPTP in conditioning the heart - translatability and mechanismThe GSK-3 family as therapeutic target for myocardial diseasesRedox modification of cell signaling in the cardiovascular systemCircadian influences on myocardial infarctionNuclear miRNA regulates the mitochondrial genome in the heartGSK-3alpha directly regulates beta-adrenergic signaling and the response of the heart to hemodynamic stress in miceMitochondrial adenine nucleotide transport and cardioprotectionAffixing N-terminal α-helix to the wall of the voltage-dependent anion channel does not prevent its voltage gating.Translocation of glycogen synthase kinase-3β (GSK-3β), a trigger of permeability transition, is kinase activity-dependent and mediated by interaction with voltage-dependent anion channel 2 (VDAC2).VDAC inhibition by tubulin and its physiological implications.Involvment of cytosolic and mitochondrial GSK-3beta in mitochondrial dysfunction and neuronal cell death of MPTP/MPP-treated neuronsPivotal role of mTORC2 and involvement of ribosomal protein S6 in cardioprotective signalingFacilitation of mitochondrial outer and inner membrane permeabilization and cell death in oxidative stress by a novel Bcl-2 homology 3 domain protein.Mitochondrial VDAC1: A Key Gatekeeper as Potential Therapeutic TargetMechanisms of pathogenesis in drug hepatotoxicity putting the stress on mitochondria.Phosphorylation of voltage-dependent anion channel by serine/threonine kinases governs its interaction with tubulin.What can we learn about cardioprotection from the cardiac mitochondrial proteome?Mitochondrial targets for volatile anesthetics against cardiac ischemia-reperfusion injuryChronic ethanol consumption enhances sensitivity to Ca(2+)-mediated opening of the mitochondrial permeability transition pore and increases cyclophilin D in liver.Free tubulin modulates mitochondrial membrane potential in cancer cells.Phosphoproteome analysis reveals regulatory sites in major pathways of cardiac mitochondria.Mitigation of carbon tetrachloride-induced hepatic injury by methylene blue, a repurposed drug, is mediated by dual inhibition of GSK3β downstream of PKA.Mitochondrial kinase signalling pathways in myocardial protection from ischaemia/reperfusion-induced necrosis.ATP/ADP ratio, the missed connection between mitochondria and the Warburg effect.Mitochondrial approaches to protect against cardiac ischemia and reperfusion injury.miR-181c regulates the mitochondrial genome, bioenergetics, and propensity for heart failure in vivo.Intracellular zinc release-activated ERK-dependent GSK-3β-p53 and Noxa-Mcl-1 signaling are both involved in cardiac ischemic-reperfusion injury.The beneficial effects of AMP kinase activation against oxidative stress are associated with prevention of PPARα-cyclophilin D interaction in cardiomyocytes.Perspectives on: SGP symposium on mitochondrial physiology and medicine: mitochondrial proteome design: from molecular identity to pathophysiological regulation.What makes the mitochondria a killer? Can we condition them to be less destructive?Cardioprotection and altered mitochondrial adenine nucleotide transportWarburg revisited: regulation of mitochondrial metabolism by voltage-dependent anion channels in cancer cells.Flurbiprofen, a cyclooxygenase inhibitor, protects mice from hepatic ischemia/reperfusion injury by inhibiting GSK-3β signaling and mitochondrial permeability transitionErbB2 overexpression upregulates antioxidant enzymes, reduces basal levels of reactive oxygen species, and protects against doxorubicin cardiotoxicity.Succination is Increased on Select Proteins in the Brainstem of the NADH dehydrogenase (ubiquinone) Fe-S protein 4 (Ndufs4) Knockout Mouse, a Model of Leigh Syndrome.Characterization of the sex-dependent myocardial S-nitrosothiol proteome.MicroRNA-7 Regulates the Function of Mitochondrial Permeability Transition Pore by Targeting VDAC1 Expression.Akt phosphorylates HK-II at Thr-473 and increases mitochondrial HK-II association to protect cardiomyocytes
P2860
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P2860
Glycogen synthase kinase 3 inhibition slows mitochondrial adenine nucleotide transport and regulates voltage-dependent anion channel phosphorylation.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh-hant
name
Glycogen synthase kinase 3 inh ...... anion channel phosphorylation.
@en
Glycogen synthase kinase 3 inh ...... anion channel phosphorylation.
@nl
type
label
Glycogen synthase kinase 3 inh ...... anion channel phosphorylation.
@en
Glycogen synthase kinase 3 inh ...... anion channel phosphorylation.
@nl
prefLabel
Glycogen synthase kinase 3 inh ...... anion channel phosphorylation.
@en
Glycogen synthase kinase 3 inh ...... anion channel phosphorylation.
@nl
P2093
P2860
P1433
P1476
Glycogen synthase kinase 3 inh ...... anion channel phosphorylation.
@en
P2093
Charles Steenbergen
Elizabeth Murphy
Nishadi Rajapakse
Renee Wong
Samarjit Das
P2860
P304
P356
10.1161/CIRCRESAHA.108.178970
P577
2008-09-18T00:00:00Z