Cytochrome P450-mediated epoxidation of 2-aminothiazole-based AKT inhibitors: identification of novel GSH adducts and reduction of metabolic activation through structural changes guided by in silico and in vitro screening.
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Chemical Biology, Molecular Mechanism and Clinical Perspective of γ-Secretase Modulators in Alzheimer's DiseaseThe generation, detection, and effects of reactive drug metabolites.Practical approaches to resolving reactive metabolite liabilities in early discovery.Reversible inhibitors of LSD1 as therapeutic agents in acute myeloid leukemia: clinical significance and progress to date.Modeling Epoxidation of Drug-like Molecules with a Deep Machine Learning Network.Selective Time- and NADPH-Dependent Inhibition of Human CYP2E1 by Clomethiazole.
P2860
Cytochrome P450-mediated epoxidation of 2-aminothiazole-based AKT inhibitors: identification of novel GSH adducts and reduction of metabolic activation through structural changes guided by in silico and in vitro screening.
description
2010 nî lūn-bûn
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2010年の論文
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2010年学术文章
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2010年学术文章
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2010年学术文章
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2010年学术文章
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2010年学术文章
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2010年學術文章
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name
Cytochrome P450-mediated epoxi ...... silico and in vitro screening.
@en
Cytochrome P450-mediated epoxi ...... silico and in vitro screening.
@nl
type
label
Cytochrome P450-mediated epoxi ...... silico and in vitro screening.
@en
Cytochrome P450-mediated epoxi ...... silico and in vitro screening.
@nl
prefLabel
Cytochrome P450-mediated epoxi ...... silico and in vitro screening.
@en
Cytochrome P450-mediated epoxi ...... silico and in vitro screening.
@nl
P2093
P356
P1476
Cytochrome P450-mediated epoxi ...... silico and in vitro screening.
@en
P2093
Chester C Yuan
Christopher Fotsch
Fang-Tsao Hong
G Erich Wohlhieter
Gary L Skiles
Guomin Yao
John G Allen
Matthew P Bourbeau
Matthew R Lee
P304
P356
10.1021/TX900414G
P577
2010-03-01T00:00:00Z