The mTOR kinase determines effector versus memory CD8+ T cell fate by regulating the expression of transcription factors T-bet and Eomesodermin.
about
Interleukin-2 receptor signaling: at the interface between tolerance and immunityRegulating mammalian target of rapamycin to tune vaccination-induced CD8(+) T cell responses for tumor immunitymTOR Regulation of Lymphoid Cells in Immunity to PathogensT Cells and Cancer: How Metabolism Shapes ImmunityTCR Signaling in T Cell MemoryMetabolic regulation of T cell differentiation and functionT cell metabolism drives immunityIL-15-PI3K-AKT-mTOR: A Critical Pathway in the Life Journey of Natural Killer CellsThe role and regulation of mTOR in T-lymphocyte functionThe mTOR pathway and integrating immune regulationIntegrating canonical and metabolic signalling programmes in the regulation of T cell responsesSorting through subsets: which T-cell populations mediate highly effective adoptive immunotherapy?Fueling immunity: insights into metabolism and lymphocyte functionChimeric antigen receptor-engineered T cells for cancer immunotherapy: progress and challengesMulti-layered epigenetic mechanisms contribute to transcriptional memory in T lymphocytesSignaling by the phosphoinositide 3-kinase family in immune cellsTsc1 promotes the differentiation of memory CD8+ T cells via orchestrating the transcriptional and metabolic programsThe kinase mTOR modulates the antibody response to provide cross-protective immunity to lethal infection with influenza virus.Therapy with m-TOR inhibitors decreases the response to the pandemic influenza A H1N1 vaccine in solid organ transplant recipients.The impact of obesity on the immune response to infection.CD8(+) T-cell effector function and transcriptional regulation during HIV pathogenesisHighlights of the advances in basic immunology in 2011.Role of Triggering Receptor Expressed on Myeloid Cell-1 Expression in Mammalian Target of Rapamycin Modulation of CD8+ T-cell Differentiation during the Immune Response to Invasive Pulmonary AspergillosisShaping successful and unsuccessful CD8 T cell responses following infection.NK cell maturation and function in C57BL/6 mice are altered by caloric restriction.Role of tumor suppressor TSC1 in regulating antigen-specific primary and memory CD8 T cell responses to bacterial infection.Characterization of the metabolic phenotype of rapamycin-treated CD8+ T cells with augmented ability to generate long-lasting memory cellsGamma(c) deficiency precludes CD8+ T cell memory despite formation of potent T cell effectors.Immune memory-boosting dose of rapamycin impairs macrophage vesicle acidification and curtails glycolysis in effector CD8 cells, impairing defense against acute infectionsEarly events governing memory CD8+ T-cell differentiation.Transcriptional control of effector and memory CD8+ T cell differentiation.IL-12 is required for mTOR regulation of memory CTLs during viral infection.TSC1/2 signaling complex is essential for peripheral naïve CD8+ T cell survival and homeostasis in mice.Cutting edge: The transcription factor eomesodermin enables CD8+ T cells to compete for the memory cell niche.Transcriptome profiling of CTLs regulated by rapamycin using RNA-SeqEarly signals during CD8 T cell priming regulate the generation of central memory cells.Insight into the role of mTOR and metabolism in T cells reveals new potential approaches to preventing graft rejection.Lineage relationship of CD8(+) T cell subsets is revealed by progressive changes in the epigenetic landscapeT-box transcription factor 21 expression in breast cancer and its relationship with prognosis.A central role for Notch in effector CD8(+) T cell differentiation
P2860
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P2860
The mTOR kinase determines effector versus memory CD8+ T cell fate by regulating the expression of transcription factors T-bet and Eomesodermin.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年学术文章
@wuu
2010年学术文章
@zh
2010年学术文章
@zh-cn
2010年学术文章
@zh-hans
2010年学术文章
@zh-my
2010年学术文章
@zh-sg
2010年學術文章
@yue
2010年學術文章
@zh-hant
name
The mTOR kinase determines eff ...... actors T-bet and Eomesodermin.
@en
The mTOR kinase determines eff ...... actors T-bet and Eomesodermin.
@nl
type
label
The mTOR kinase determines eff ...... actors T-bet and Eomesodermin.
@en
The mTOR kinase determines eff ...... actors T-bet and Eomesodermin.
@nl
prefLabel
The mTOR kinase determines eff ...... actors T-bet and Eomesodermin.
@en
The mTOR kinase determines eff ...... actors T-bet and Eomesodermin.
@nl
P2093
P2860
P1433
P1476
The mTOR kinase determines eff ...... actors T-bet and Eomesodermin.
@en
P2093
Protul A Shrikant
Qingsheng Li
Rajesh R Rao
P2860
P356
10.1016/J.IMMUNI.2009.10.010
P407
P50
P577
2010-01-07T00:00:00Z