Exploring the substrate promiscuity of drug-modifying enzymes for the chemoenzymatic generation of N-acylated aminoglycosides.
about
Strategies to overcome the action of aminoglycoside-modifying enzymes for treating resistant bacterial infectionsUnusual regioversatility of acetyltransferase Eis, a cause of drug resistance in XDR-TBChemical and Structural Insights into the Regioversatility of the Aminoglycoside Acetyltransferase EisPotent Inhibitors of Acetyltransferase Eis Overcome Kanamycin Resistance in Mycobacterium tuberculosisAminoglycoside modifying enzymes.A chemoenzymatic route to diversify aminoglycosides enables a microarray-based method to probe acetyltransferase activity.MALDI-TOF MS: an upcoming tool for rapid detection of antibiotic resistance in microorganisms.Rapid synthesis, RNA binding, and antibacterial screening of a peptidic-aminosugar (PA) libraryInfluence of linker length and composition on enzymatic activity and ribosomal binding of neomycin dimers.Inhibition of aminoglycoside acetyltransferase resistance enzymes by metal salts.Amphiphilic Tobramycin Analogues as Antibacterial and Antifungal Agents.Chemically related 4,5-linked aminoglycoside antibiotics drive subunit rotation in opposite directionsIdentification and characterization of inhibitors of the aminoglycoside resistance acetyltransferase Eis from Mycobacterium tuberculosisAminoglycoside multiacetylating activity of the enhanced intracellular survival protein from Mycobacterium smegmatis and its inhibition.Synthesis and Biological Activity of Mono- and Di-N-acylated Aminoglycosides.Cosubstrate tolerance of the aminoglycoside resistance enzyme Eis from Mycobacterium tuberculosisBiochemical and structural analysis of aminoglycoside acetyltransferase Eis from Anabaena variabilisArginine-linked neomycin B dimers: synthesis, rRNA binding, and resistance enzyme activity.Mechanisms of Resistance to Aminoglycoside Antibiotics: Overview and PerspectivesA review of patents (2011-2015) towards combating resistance to and toxicity of aminoglycosidesDomain dissection and characterization of the aminoglycoside resistance enzyme ANT(3″)-Ii/AAC(6')-IId from Serratia marcescens.Rise and dissemination of aminoglycoside resistance: the aac(6')-Ib paradigm.Synthesis and evaluation of hetero- and homodimers of ribosome-targeting antibiotics: antimicrobial activity, in vitro inhibition of translation, and drug resistance.Comparative Study of Eis-like Enzymes from Pathogenic and Nonpathogenic Bacteria.Synthesis and Bioactivities of Kanamycin B-Derived Cationic Amphiphiles.Inhaled antibiotics for gram-negative respiratory infections.2-Deoxystreptamine-containing aminoglycoside antibiotics: recent advances in the characterization and manipulation of their biosynthetic pathways.N6', N6''', and O4' Modifications to Neomycin Affect Ribosomal Selectivity without Compromising Antibacterial Activity.Discovery and Optimization of Two Eis Inhibitor Families as Kanamycin Adjuvants against Drug-Resistant M. tuberculosis.Sulfonamide-Based Inhibitors of Aminoglycoside Acetyltransferase Eis Abolish Resistance to Kanamycin in Mycobacterium tuberculosis.Expanding Aminoglycoside Resistance Enzyme Regiospecificity by Mutation and Truncation.Effects of altering aminoglycoside structures on bacterial resistance enzyme activities.Tobramycin Variants with Enhanced Ribosome-Targeting ActivityHighly selective acylation of polyamines and aminoglycosides by 5-acyl-5-phenyl-1,5-dihydro-4H-pyrazol-4-ones.Comprehensive review of chemical strategies for the preparation of new aminoglycosides and their biological activities.Antimicrobial Activity, AME Resistance, and A-Site Binding Studies of Anthraquinone-Neomycin Conjugates.Assessment of 6'- and 6'''-N-acylation of aminoglycosides as a strategy to overcome bacterial resistance.Flipping the Switch "On" for Aminoglycoside-Resistance Enzymes: The Mechanism Is Finally Revealed!Antifungal amphiphilic kanamycins: new life for an old drugNucleoside triphosphate cosubstrates control the substrate profile and efficiency of aminoglycoside 3'--phosphotransferase type IIa
P2860
Q26859978-EB120042-1C25-4013-865B-6E50EBD51AF3Q27668103-2B42168D-FD2C-4F85-9306-97A58232EE1FQ27680200-50B65E8A-580F-404F-A154-0ED4F482136FQ27704295-040264CC-3DC1-4309-96DE-5853689787DCQ34354185-0D34C223-B9B3-4943-A56A-0480895131C8Q34470492-A8E41778-4CC3-4A7B-B1AD-F931FC071388Q35016718-64EA8DDB-BCD1-4DC9-A3ED-AB134C1F578EQ35565745-8EDAB8F9-E7BA-4036-97EE-36E8AB13ED9FQ35746019-CA9BD263-C086-4327-9E98-6CF604BEB4C2Q35746230-7DA67397-B0E8-42AE-8670-3778B31B8398Q35859918-FEFB395D-7558-4192-B042-8CB9896DA123Q35909870-720E11A6-8D1E-4495-9EB6-B78BFE1D8884Q36107474-5526CF4B-9354-4D39-8695-A8625837744CQ36185972-D91A2334-2ADB-48A3-B35F-8CC8AE170A87Q36281015-A317422D-35ED-4EB6-AD7C-BCD3034932DFQ36364084-53ED007C-594E-40E4-8E08-450A1259822FQ36395315-478C40CA-2743-4BE0-B36D-1830A6E6F7D1Q36490493-B82E7FF5-5612-4AD8-ACE0-6673E7760209Q36575916-BB4136FF-2F42-4807-AE14-6E976C97289DQ36726249-0339F8DD-F123-49DF-963B-830E9088C9DDQ36823942-95666A83-D2B2-4B96-A3A4-FF856EF98ADBQ36850490-D5C32E70-6CCB-4CD7-A1B6-0A0F9BC90CE3Q37296998-5B64B88A-2C43-41D6-9501-36B1F9796FDAQ37499353-7B43B099-CF54-45B2-9497-AC25DC42867CQ37499358-4F5763F2-9DA8-44D3-9C32-7DA30B838CC7Q37937558-2FD76668-C80F-449D-9678-28B7494D3B61Q38062339-8FA81A74-4208-4421-9903-58408C31338BQ40278411-139B971E-EB5E-4E78-BD1E-BC41D67CE702Q40416937-AABB704D-1884-414F-8DD2-51E87401C72DQ40433292-4676FF32-7DB4-47A2-B699-528C926DAB27Q40543501-3D8BE7D0-8BFD-4450-82FB-49E9BF493234Q41838457-9A39BAF3-A425-4F41-84C2-28D849895039Q42138277-BB5771CD-AA6E-429F-87DE-3DCFEFCD2165Q42705845-A6459083-3CE9-4B39-8CC6-836BAA83785CQ48317932-64AFD774-9D75-40DA-8F87-71B8BFA80BFFQ48334900-48C035E0-7081-4A10-BAE8-3B3A1F9365F5Q50525805-B66963C6-AE17-4889-B07A-E74167FCD5A1Q53005540-0FE96BC2-0D5F-4ED7-9630-32E8BF435C74Q57103893-B2FA5E71-134B-4754-9B78-41A4FBA84156Q57814963-F6E39DF0-1ECD-41CE-9CA9-8D96F1E32527
P2860
Exploring the substrate promiscuity of drug-modifying enzymes for the chemoenzymatic generation of N-acylated aminoglycosides.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年学术文章
@wuu
2010年学术文章
@zh
2010年学术文章
@zh-cn
2010年学术文章
@zh-hans
2010年学术文章
@zh-my
2010年学术文章
@zh-sg
2010年學術文章
@yue
2010年學術文章
@zh-hant
name
Exploring the substrate promis ...... of N-acylated aminoglycosides.
@en
Exploring the substrate promis ...... of N-acylated aminoglycosides.
@nl
type
label
Exploring the substrate promis ...... of N-acylated aminoglycosides.
@en
Exploring the substrate promis ...... of N-acylated aminoglycosides.
@nl
prefLabel
Exploring the substrate promis ...... of N-acylated aminoglycosides.
@en
Exploring the substrate promis ...... of N-acylated aminoglycosides.
@nl
P2093
P356
P1433
P1476
Exploring the substrate promis ...... of N-acylated aminoglycosides.
@en
P2093
Jacob L Houghton
Keith D Green
Micha Fridman
Wenjing Chen
P2860
P304
P356
10.1002/CBIC.200900584
P577
2010-01-01T00:00:00Z