Co-translational interactions of apoprotein B with the ribosome and translocon during lipoprotein assembly or targeting to the proteasome.
about
The delicate balance between secreted protein folding and endoplasmic reticulum-associated degradation in human physiologySec61p is part of the endoplasmic reticulum-associated degradation machineryOverexpression of the tumor autocrine motility factor receptor Gp78, a ubiquitin protein ligase, results in increased ubiquitinylation and decreased secretion of apolipoprotein B100 in HepG2 cellsNascent lipidated apolipoprotein B is transported to the Golgi as an incompletely folded intermediate as probed by its association with network of endoplasmic reticulum molecular chaperones, GRP94, ERp72, BiP, calreticulin, and cyclophilin BApolipoprotein B: a clinically important apolipoprotein which assembles atherogenic lipoproteins and promotes the development of atherosclerosisEpigallocatechin gallate increases the formation of cytosolic lipid droplets and decreases the secretion of apoB-100 VLDLMicrosomal triglyceride transfer protein and its role in apoB-lipoprotein assemblyApolipoprotein B100 quality control and the regulation of hepatic very low density lipoprotein secretion.Complexity in the secretory pathway: the assembly and secretion of apolipoprotein B-containing lipoproteins.Structure, function, and regulation of free and membrane-bound ribosomes: the view from their substrates and products.Growth-based determination and biochemical confirmation of genetic requirements for protein degradation in Saccharomyces cerevisiaeProduction of Cloned Miniature Pigs Expressing High Levels of Human Apolipoprotein(a) in Plasma.Protein disulfide isomerases contribute differentially to the endoplasmic reticulum-associated degradation of apolipoprotein B and other substratesAberrant substrate engagement of the ER translocon triggers degradation by the Hrd1 ubiquitin ligase.Dislocation and degradation from the ER are regulated by cytosolic stress.Monogenic hypocholesterolaemic lipid disorders and apolipoprotein B metabolism.Apolipoproteins A-I and B: biosynthesis, role in the development of atherosclerosis and targets for intervention against cardiovascular disease.Role of the gut in lipid homeostasisCadmium and Secondary Structure-dependent Function of a Degron in the Pca1p Cadmium Exporter.Cycloheximide Chase Analysis of Protein Degradation in Saccharomyces cerevisiaeThe Hsp110 molecular chaperone stabilizes apolipoprotein B from endoplasmic reticulum-associated degradation (ERAD)The many intersecting pathways underlying apolipoprotein B secretion and degradationDocosahexaenoic acid impairs the maturation of very low density lipoproteins in rat hepatic cells.Apolipoprotein B100 biogenesis: a complex array of intracellular mechanisms regulating folding, stability, and lipoprotein assembly.Insights from human congenital disorders of intestinal lipid metabolism.Acetylation of N-terminus and two internal amino acids is dispensable for degradation of a protein that aberrantly engages the endoplasmic reticulum translocon.The AAA-ATPase p97 facilitates degradation of apolipoprotein B by the ubiquitin-proteasome pathway.Cytoplasmic lipid droplets are sites of convergence of proteasomal and autophagic degradation of apolipoprotein B.Apple procyanidins decrease cholesterol esterification and lipoprotein secretion in Caco-2/TC7 enterocytes.Relation of the size and intracellular sorting of apoB to the formation of VLDL 1 and VLDL 2.Amino acid sequences within the beta1 domain of human apolipoprotein B can mediate rapid intracellular degradation.Apolipoprotein B is synthesized in selected human non-hepatic cell lines but not processed into mature lipoprotein.Influence of peroxisome proliferator-activated receptor alpha agonists on the intracellular turnover and secretion of apolipoprotein (Apo) B-100 and ApoB-48.The late addition of core lipids to nascent apolipoprotein B100, resulting in the assembly and secretion of triglyceride-rich lipoproteins, is independent of both microsomal triglyceride transfer protein activity and new triglyceride synthesis.A proteomic approach identifies proteins in hepatocytes that bind nascent apolipoprotein B.Protein unfolding is not a prerequisite for endoplasmic reticulum-to-cytosol dislocation.Blocking microsomal triglyceride transfer protein interferes with apoB secretion without causing retention or stress in the ER.Ferritins can regulate the secretion of apolipoprotein B.The conversion of apoB100 low density lipoprotein/high density lipoprotein particles to apoB100 very low density lipoproteins in response to oleic acid occurs in the endoplasmic reticulum and not in the Golgi in McA RH7777 cells.Translocation efficiency of apolipoprotein B is determined by the presence of beta-sheet domains, not pause transfer sequences.
P2860
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P2860
Co-translational interactions of apoprotein B with the ribosome and translocon during lipoprotein assembly or targeting to the proteasome.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
2001年學術文章
@zh-hant
name
Co-translational interactions ...... r targeting to the proteasome.
@en
Co-translational interactions ...... r targeting to the proteasome.
@nl
type
label
Co-translational interactions ...... r targeting to the proteasome.
@en
Co-translational interactions ...... r targeting to the proteasome.
@nl
prefLabel
Co-translational interactions ...... r targeting to the proteasome.
@en
Co-translational interactions ...... r targeting to the proteasome.
@nl
P2093
P2860
P356
P1476
Co-translational interactions ...... r targeting to the proteasome.
@en
P2093
A E Johnson
H N Ginsberg
J D Aitchison
R Pariyarath
P2860
P304
P356
10.1074/JBC.M007944200
P407
P577
2001-01-01T00:00:00Z