Molecular determinants of voltage-dependent gating and binding of pore-blocking drugs in transmembrane segment IIIS6 of the Na(+) channel alpha subunit.
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Structural determinants of drugs acting on the Nav1.8 channelRegulation of sodium channel function by bilayer elasticity: the importance of hydrophobic coupling. Effects of Micelle-forming amphiphiles and cholesterolMolecular basis of ranolazine block of LQT-3 mutant sodium channels: evidence for site of actionMolecular targets for antiepileptic drug developmentThe hitchhiker's guide to the voltage-gated sodium channel galaxyNa+ channel function, regulation, structure, trafficking and sequestrationCrystal structure of a voltage-gated sodium channel in two potentially inactivated statesProkaryotic NavMs channel as a structural and functional model for eukaryotic sodium channel antagonismStructural Basis for Pharmacology of Voltage-Gated Sodium and Calcium ChannelsThe neurobiology of antiepileptic drugsResidue-specific effects on slow inactivation at V787 in D2-S6 of Na(v)1.4 sodium channels.Inactivation determinants in segment IIIS6 of Ca(v)3.1Increased rigidity of the chiral centre of tocainide favours stereoselectivity and use-dependent block of skeletal muscle Na(+) channels enhancing the antimyotonic activity in vivoFast- or slow-inactivated state preference of Na+ channel inhibitors: a simulation and experimental studyStructure and function of voltage-gated sodium channels at atomic resolution.Synthesis and biological evaluation of a fluorescent analog of phenytoin as a potential inhibitor of neuropathic pain and imaging agent.Asymmetric synthesis and evaluation of a hydroxyphenylamide voltage-gated sodium channel blocker in human prostate cancer xenograftsSynthesis and evaluation of hermitamides A and B as human voltage-gated sodium channel blockersAnticonvulsant activity of 2,4(1H)-diarylimidazoles in mice and rats acute seizure models.Ligand-based design and synthesis of novel sodium channel blockers from a combined phenytoin-lidocaine pharmacophoreA pharmacophore derived phenytoin analogue with increased affinity for slow inactivated sodium channels exhibits a desired anticonvulsant profileStructural model of the open-closed-inactivated cycle of prokaryotic voltage-gated sodium channels.Probing the non-covalent binding interaction of the Na+ channel inactivation gate peptide in a linker between domain III and IV with 5,5-diphenyhydantoin in electrospray ion trap tandem mass spectrometry.Analysis of FeII-mediated decomposition of a linoleic acid-derived lipid hydroperoxide by liquid chromatography/mass spectrometry.Molecular determinants of coupling between the domain III voltage sensor and pore of a sodium channelMechanism of inactivation gating of human T-type (low-voltage activated) calcium channels.Tryptophan scanning of D1S6 and D4S6 C-termini in voltage-gated sodium channelsTryptophan substitution of a putative D4S6 gating hinge alters slow inactivation in cardiac sodium channels.Molecular mechanism of allosteric modification of voltage-dependent sodium channels by local anestheticsVoltage-gated sodium channels at 60: structure, function and pathophysiology.Molecular model of anticonvulsant drug binding to the voltage-gated sodium channel inner pore.HIV-1 protease inhibitor induces growth arrest and apoptosis of human prostate cancer LNCaP cells in vitro and in vivo in conjunction with blockade of androgen receptor STAT3 and AKT signaling.Pharmacology and Toxicology of Nav1.5-Class 1 anti-arrhythmic drugs.Analysis of the action of lidocaine on insect sodium channels.Molecular determinants of state-dependent block of voltage-gated sodium channels by pilsicainide.Molecular basis of differential sensitivity of insect sodium channels to DCJW, a bioactive metabolite of the oxadiazine insecticide indoxacarb.Bacterial voltage-gated sodium channels (BacNa(V)s) from the soil, sea, and salt lakes enlighten molecular mechanisms of electrical signaling and pharmacology in the brain and heart.Two-pore channels provide insight into the evolution of voltage-gated Ca2+ and Na+ channels.Inhibition of neuronal voltage-gated sodium channels by brilliant blue GEvaluation of the pharmacological activity of the major mexiletine metabolites on skeletal muscle sodium currents.
P2860
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P2860
Molecular determinants of voltage-dependent gating and binding of pore-blocking drugs in transmembrane segment IIIS6 of the Na(+) channel alpha subunit.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
2001年學術文章
@zh-hant
name
Molecular determinants of volt ...... mbrane segment IIIS6 of the Na
@nl
Molecular determinants of volt ...... e Na(+) channel alpha subunit.
@en
type
label
Molecular determinants of volt ...... mbrane segment IIIS6 of the Na
@nl
Molecular determinants of volt ...... e Na(+) channel alpha subunit.
@en
prefLabel
Molecular determinants of volt ...... mbrane segment IIIS6 of the Na
@nl
Molecular determinants of volt ...... e Na(+) channel alpha subunit.
@en
P2093
P2860
P356
P1476
Molecular determinants of volt ...... he Na(+) channel alpha subunit
@en
P2093
P2860
P356
10.1074/JBC.M006992200
P407
P577
2001-01-01T00:00:00Z