A Mek1-Mek2 heterodimer determines the strength and duration of the Erk signal.
about
Nek10 mediates G2/M cell cycle arrest and MEK autoactivation in response to UV irradiationTunable-combinatorial mechanisms of acquired resistance limit the efficacy of BRAF/MEK cotargeting but result in melanoma drug addiction.Raf family kinases: old dogs have learned new tricksNegative feedback regulation of the ERK1/2 MAPK pathwayRaf kinases in cancer-roles and therapeutic opportunitiesModeling of tumor progression in NSCLC and intrinsic resistance to TKI in loss of PTEN expressionRegulation of the mitogen-activated protein kinase kinase (MEK)-1 by NAD(+)-dependent deacetylasesGenome scale modeling in systems biology: algorithms and resources.Ras Dimer Formation as a New Signaling Mechanism and Potential Cancer Therapeutic Target.From basic research to clinical development of MEK1/2 inhibitors for cancer therapy.Targeting signal transduction pathways to eliminate chemotherapeutic drug resistance and cancer stem cells.Phylogenomic analysis of MKKs and MAPKs from 16 legumes and detection of interacting pairs in chickpea divulge MAPK signalling modules.MAPK signaling to the early secretory pathway revealed by kinase/phosphatase functional screeningExtracellular signal-regulated kinases 1 and 2 regulate the balance between eccentric and concentric cardiac growthOptical control of cell signaling by single-chain photoswitchable kinasesStress-induced enzyme activation primes murine embryonic stem cells to differentiate toward the first extraembryonic lineageERK2 is essential for the growth of human epithelioid malignant mesotheliomas.Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging.Dentate Gyrus Development Requires ERK Activity to Maintain Progenitor Population and MAPK Pathway Feedback Regulation.Regulation of ERK Kinase by MEK1 Kinase Inhibition in the BrainA novel role for copper in Ras/mitogen-activated protein kinase signaling.MEK guards proteome stability and inhibits tumor-suppressive amyloidogenesis via HSF1.MEK genomics in development and diseaseAberrant REDD1-mTORC1 responses to insulin in skeletal muscle from Type 2 diabeticsIntrinsically active variants of Erk oncogenically transform cells and disclose unexpected autophosphorylation capability that is independent of TEY phosphorylationMEK1 is required for PTEN membrane recruitment, AKT regulation, and the maintenance of peripheral toleranceMutations and deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascades which alter therapy response.Exploiting conformational ensembles in modeling protein-protein interactions on the proteome scale.Enhancing therapeutic efficacy by targeting non-oncogene addicted cells with combinations of signal transduction inhibitors and chemotherapySynergistic antitumor effects of combination PI3K/mTOR and MEK inhibition (SAR245409 and pimasertib) in mucinous ovarian carcinoma cells by fluorescence resonance energy transfer imaging.Rapamycin induces mitogen-activated protein (MAP) kinase phosphatase-1 (MKP-1) expression through activation of protein kinase B and mitogen-activated protein kinase kinase pathways.Emerging Raf inhibitors.The genetic landscape of clinical resistance to RAF inhibition in metastatic melanoma.Direct binding of MEK1 and MEK2 to AKT induces Foxo1 phosphorylation, cellular migration and metastasis.MEK1 is required for the development of NRAS-driven leukemia.Towards a molecular understanding of the differential signals regulating alphabeta/gammadelta T lineage choice.Novel mitogen-activated protein kinase kinase inhibitors.Roles of the Ras/Raf/MEK/ERK pathway in leukemia therapy.The ERK Cascade: Distinct Functions within Various Subcellular Organelles.Mitogen-Activated Protein (MAP) Kinase Scaffolding Proteins: A Recount.
P2860
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P2860
A Mek1-Mek2 heterodimer determines the strength and duration of the Erk signal.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
2009年學術文章
@zh-hant
name
A Mek1-Mek2 heterodimer determines the strength and duration of the Erk signal.
@en
A Mek1-Mek2 heterodimer determines the strength and duration of the Erk signal.
@nl
type
label
A Mek1-Mek2 heterodimer determines the strength and duration of the Erk signal.
@en
A Mek1-Mek2 heterodimer determines the strength and duration of the Erk signal.
@nl
prefLabel
A Mek1-Mek2 heterodimer determines the strength and duration of the Erk signal.
@en
A Mek1-Mek2 heterodimer determines the strength and duration of the Erk signal.
@nl
P2093
P356
P1476
A Mek1-Mek2 heterodimer determines the strength and duration of the Erk signal.
@en
P2093
Federica Catalanotti
Gergana Galabova-Kovacs
Gloria Reyes
Oliviero Carugo
Ricardo de Matos Simoes
Veronika Jesenberger
P2860
P2888
P304
P356
10.1038/NSMB.1564
P577
2009-02-15T00:00:00Z