Intracellular distribution and late endosomal effects of the ocular albinism type 1 gene product: consequences of disease-causing mutations and implications for melanosome biogenesis.
about
L-DOPA is an endogenous ligand for OA1The melanosomal/lysosomal protein OA1 has properties of a G protein-coupled receptorAn unconventional dileucine-based motif and a novel cytosolic motif are required for the lysosomal and melanosomal targeting of OA1Mutational analysis of the OA1 gene in ocular albinismNew insights into ocular albinism type 1 (OA1): Mutations and polymorphisms of the OA1 geneTriazine-based tyrosinase inhibitors identified by chemical genetic screening.Identification of quinolines that inhibit melanogenesis by altering tyrosinase family trafficking.Identification of Novel G Protein-Coupled Receptor 143 Ligands as Pharmacologic Tools for Investigating X-Linked Ocular AlbinismSignaling pathways in melanosome biogenesis and pathologyDoes levodopa improve vision in albinism? Results of a randomized, controlled clinical trial.Location-dependent signaling of the group 1 metabotropic glutamate receptor mGlu5.Dual loss of ER export and endocytic signals with altered melanosome morphology in the silver mutation of Pmel17Abnormal crossing of the optic fibres shown by evoked magnetic fields in patients with ocular albinism with a novel mutation in the OA1 gene.Melanoregulin, product of the dsu locus, links the BLOC-pathway and OA1 in organelle biogenesis.The ocular albinism type 1 gene product, OA1, spans intracellular membranes 7 timesMechanisms Associated with Activation of Intracellular Metabotropic Glutamate Receptor, mGluR5.Melanosome-autonomous regulation of size and number: the OA1 receptor sustains PMEL expression.Pink-eyed dilution protein controls the processing of tyrosinase.25-hydroxycholesterol acts in the Golgi compartment to induce degradation of tyrosinase.Accumulation of tyrosinase in the endolysosomal compartment is induced by U18666A.Expression of OA1 limits the fusion of a subset of MVBs with lysosomes - a mechanism potentially involved in the initial biogenesis of melanosomes.Regulation of tyrosinase processing and trafficking by organellar pH and by proteasome activity.
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P2860
Intracellular distribution and late endosomal effects of the ocular albinism type 1 gene product: consequences of disease-causing mutations and implications for melanosome biogenesis.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
2001年學術文章
@zh-hant
name
Intracellular distribution and ...... ons for melanosome biogenesis.
@en
Intracellular distribution and ...... ons for melanosome biogenesis.
@nl
type
label
Intracellular distribution and ...... ons for melanosome biogenesis.
@en
Intracellular distribution and ...... ons for melanosome biogenesis.
@nl
prefLabel
Intracellular distribution and ...... ons for melanosome biogenesis.
@en
Intracellular distribution and ...... ons for melanosome biogenesis.
@nl
P2860
P1433
P1476
Intracellular distribution and ...... ons for melanosome biogenesis.
@en
P2093
P2860
P304
P356
10.1034/J.1600-0854.2001.020306.X
P50
P577
2001-03-01T00:00:00Z