CEP-1347/KT-7515, an inhibitor of SAPK/JNK pathway activation, promotes survival and blocks multiple events associated with Abeta-induced cortical neuron apoptosis.
about
Oxidative Stress Signaling in Alzheimers DiseaseAmyloid-beta neurotoxicity is mediated by FISH adapter protein and ADAM12 metalloprotease activityDown-regulation of DENN/MADD, a TNF receptor binding protein, correlates with neuronal cell death in Alzheimer's disease brain and hippocampal neuronsc-Jun N-terminal Kinase (JNK) Signaling as a Therapeutic Target for Alzheimer's DiseaseEvaluation of traditional medicines for neurodegenerative diseases using Drosophila modelsNeuropsychiatric Disturbances in Alzheimer's Disease: What Have We Learned from Neuropathological Studies?Endophilin I expression is increased in the brains of Alzheimer disease patientsdp5/HRK is a c-Jun target gene and required for apoptosis induced by potassium deprivation in cerebellar granule neuronsTetrahydrocannabinol-induced neurotoxicity depends on CB1 receptor-mediated c-Jun N-terminal kinase activation in cultured cortical neuronsA role for c-Jun N-terminal kinase 1 (JNK1), but not JNK2, in the beta-amyloid-mediated stabilization of protein p53 and induction of the apoptotic cascade in cultured cortical neuronsSmall molecule, non-peptide p75 ligands inhibit Abeta-induced neurodegeneration and synaptic impairment.Neuroprotective activities of CEP-1347 in models of neuroAIDS.TNF ligands and receptors--a matter of life and death.The JNK/c-Jun cascade and Alzheimer's disease.Ras-MAP kinase signaling pathways and control of cell proliferation: relevance to cancer therapy.Death and survival of neuronal cells exposed to Alzheimer's insults.MAPKs: new targets for neurodegeneration.Functional links between Aβ toxicity, endocytic trafficking, and Alzheimer's disease risk factors in yeast.Neuronal death in Alzheimer's disease and therapeutic opportunities.Indomethacin-loaded lipid-core nanocapsules reduce the damage triggered by Aβ1-42 in Alzheimer's disease models.Genistein protects against Aβ25-35 induced apoptosis of PC12 cells through JNK signaling and modulation of Bcl-2 family messengers.Agents targeting c-Jun N-terminal kinase pathway as potential neuroprotectants.Mitochondrial dysfunction and cell death in neurodegenerative diseases through nitroxidative stressThe calcineurin inhibitor Sarah (Nebula) exacerbates Aβ42 phenotypes in a Drosophila model of Alzheimer's disease.Pharmacokinetic interactions of CEP-1347 and atazanavir in HIV-infected patients.Expression of inflammatory genes induced by beta-amyloid peptides in human brain endothelial cells and in Alzheimer's brain is mediated by the JNK-AP1 signaling pathway.Calpain5 expression is decreased in endometriosis and regulated by HOXA10 in human endometrial cells.Microglial derived tumor necrosis factor-α drives Alzheimer's disease-related neuronal cell cycle eventsMediators of tau phosphorylation in the pathogenesis of Alzheimer's disease.Glycogen synthase kinase-3beta induces neuronal cell death via direct phosphorylation of mixed lineage kinase 3.Dissecting Complex and Multifactorial Nature of Alzheimer's Disease Pathogenesis: a Clinical, Genomic, and Systems Biology Perspective.miR-98-5p Acts as a Target for Alzheimer's Disease by Regulating Aβ Production Through Modulating SNX6 Expression.Neuropharmacologic Approaches to Restore the Brain's Microenvironment.Neuronal cell death in Alzheimer's disease and a neuroprotective factor, humanin.Regulation of apoptotic c-Jun N-terminal kinase signaling by a stabilization-based feed-forward loop.Lipoarabinomannan-induced cell signaling involves ceramide and mitogen-activated protein kinase.K252a and CEP1347 are neuroprotective compounds that inhibit mixed-lineage kinase-3 and induce activation of Akt and ERK.The proapoptotic dp5 gene is a direct target of the MLK-JNK-c-Jun pathway in sympathetic neurons.Wnt5a Promotes Cortical Neuron Survival by Inhibiting Cell-Cycle ActivationThe p75 neurotrophin receptor promotes amyloid-beta(1-42)-induced neuritic dystrophy in vitro and in vivo.
P2860
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P2860
CEP-1347/KT-7515, an inhibitor of SAPK/JNK pathway activation, promotes survival and blocks multiple events associated with Abeta-induced cortical neuron apoptosis.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
2001年學術文章
@zh
2001年學術文章
@zh-hant
name
CEP-1347/KT-7515, an inhibitor ...... ced cortical neuron apoptosis.
@en
CEP-1347/KT-7515, an inhibitor ...... ced cortical neuron apoptosis.
@nl
type
label
CEP-1347/KT-7515, an inhibitor ...... ced cortical neuron apoptosis.
@en
CEP-1347/KT-7515, an inhibitor ...... ced cortical neuron apoptosis.
@nl
prefLabel
CEP-1347/KT-7515, an inhibitor ...... ced cortical neuron apoptosis.
@en
CEP-1347/KT-7515, an inhibitor ...... ced cortical neuron apoptosis.
@nl
P2093
P2860
P1476
CEP-1347/KT-7515, an inhibitor ...... ced cortical neuron apoptosis.
@en
P2093
Bozyczko-Coyne D
Dobrzanski P
P2860
P304
P356
10.1046/J.1471-4159.2001.00294.X
P407
P577
2001-05-01T00:00:00Z