Evolution of enzyme function and the development of catalytic efficiency.
about
Human triose-phosphate isomerase deficiency: a single amino acid substitution results in a thermolabile enzymeCloning, expression, and purification of human cyclophilin in Escherichia coli and assessment of the catalytic role of cysteines by site-directed mutagenesisMolecular analysis of a series of alleles in humans with reduced activity at the triosephosphate isomerase locusMechanism of poly(A) polymerase: structure of the enzyme-MgATP-RNA ternary complex and kinetic analysisCrystal structure of the secretory form of membrane-associated human carbonic anhydrase IV at 2.8-A resolutionExperimental approaches to evaluate the contributions of candidate protein-coding mutations to phenotypic evolutionCrystal structure of triosephosphate isomerase from Trypanosoma cruzi in hexaneReaction mechanism of chalcone isomerase. pH dependence, diffusion control, and product binding differencesStructure of a serine protease poised to resynthesize a peptide bondStructural basis of human triosephosphate isomerase deficiency: mutation E104D is related to alterations of a conserved water network at the dimer interfaceRevisiting the mechanism of the triosephosphate isomerase reaction: the role of the fully conserved glutamic acid 97 residueGround state destabilization by anionic nucleophiles contributes to the activity of phosphoryl transfer enzymesEvolution of the chalcone-isomerase fold from fatty-acid binding to stereospecific catalysisPrecision is essential for efficient catalysis in an evolved Kemp eliminaseProbing the role of highly conserved residues in triosephosphate isomerase--analysis of site specific mutants at positions 64 and 75 in the Plasmodial enzymeConnecting Active-Site Loop Conformations and Catalysis in Triosephosphate Isomerase: Insights from a Rare Variation at Residue 96 in the Plasmodial EnzymeDirected evolution of a pyruvate aldolase to recognize a long chain acyl substratePurification and mechanistic properties of an extracellular alpha-L-arabinofuranosidase from Monilinia fructigenaInfluence of the position of the double bond in steroid substrates on the efficiency of the proton-transfer reaction by Pseudomonas testosteroni 3-oxo-steroid delta 4-delta 5-isomeraseThe stability and formation of native proteins from unfolded monomers is increased through interactions with unrelated proteinsRapid bursts and slow declines: on the possible evolutionary trajectories of enzymesStructural effects of protein aging: terminal marking by deamidation in human triosephosphate isomerase.Functional role of a distal (3'-phosphate) group of CoA in the recombinant human liver medium-chain acyl-CoA dehydrogenase-catalysed reaction.Biological evolution of replicator systems: towards a quantitative approach.Enzyme Efficiency but Not Thermostability Drives Cefotaxime Resistance Evolution in TEM-1 β-Lactamase.New insights into enzyme catalysis. Ground state tunnelling driven by protein dynamics.How the Same Core Catalytic Machinery Catalyzes 17 Different Reactions: the Serine-Histidine-Aspartate Catalytic Triad of α/β-Hydrolase Fold Enzymes.Class C beta-lactamases operate at the diffusion limit for turnover of their preferred cephalosporin substrates.An enzymatic platform for the synthesis of isoprenoid precursors.Directed evolution to re-adapt a co-evolved network within an enzyme.Kinetics of a multistate enzyme in a large oscillating field.Improving upon nature: active site remodeling produces highly efficient aldolase activity toward hydrophobic electrophilic substrates.Irreversibility in unbranched pathways: preferred positions based on regulatory considerations.The catalytic consequences of experimental evolution. Studies on the subunit structure of the second (ebg) beta-galactosidase of Escherichia coli, and on catalysis by ebgab, an experimental evolvant containing two amino acid substitutions.The 3' substrate determinants for the catalytic efficiency of the Bacillus subtilis RNase P holoenzyme suggest autolytic processing of the RNase P RNA in vivo.Stereoelectronic control in peptide bond formation. Ab initio calculations and speculations on the mechanism of action of serine proteases.Localization of nine glycolytic enzymes in a microbody-like organelle in Trypanosoma brucei: the glycosome.Quantum mechanics/molecular mechanics investigation of the mechanism of phosphate transfer in human uridine-cytidine kinase 2.Molecular kinetics. Ras activation by SOS: allosteric regulation by altered fluctuation dynamics.Common enzymological experiments allow free energy profile determination.
P2860
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P2860
Evolution of enzyme function and the development of catalytic efficiency.
description
1976 nî lūn-bûn
@nan
1976年の論文
@ja
1976年学术文章
@wuu
1976年学术文章
@zh
1976年学术文章
@zh-cn
1976年学术文章
@zh-hans
1976年学术文章
@zh-my
1976年学术文章
@zh-sg
1976年學術文章
@yue
1976年學術文章
@zh-hant
name
Evolution of enzyme function and the development of catalytic efficiency.
@en
Evolution of enzyme function and the development of catalytic efficiency.
@nl
type
label
Evolution of enzyme function and the development of catalytic efficiency.
@en
Evolution of enzyme function and the development of catalytic efficiency.
@nl
prefLabel
Evolution of enzyme function and the development of catalytic efficiency.
@en
Evolution of enzyme function and the development of catalytic efficiency.
@nl
P356
P1433
P1476
Evolution of enzyme function and the development of catalytic efficiency.
@en
P2093
P304
P356
10.1021/BI00670A032
P407
P577
1976-12-01T00:00:00Z