Selection of drug-resistant bone marrow cells in vivo after retroviral transfer of human MDR1.
about
Towards in vivo amplification: Overcoming hurdles in the use of hematopoietic stem cells in transplantation and gene therapyAn efficient vector system to modify cells geneticallyImproved post-transcriptional processing of an MDR1 retrovirus elevates expression of multidrug resistance in primary human hematopoietic cells.Cloning and functional analysis of the rhesus macaque ABCG2 gene. Forced expression confers an SP phenotype among hematopoietic stem cell progeny in vivo.Increasing DNA repair methyltransferase levels via bone marrow stem cell transduction rescues mice from the toxic effects of 1,3-bis(2-chloroethyl)-1-nitrosourea, a chemotherapeutic alkylating agentSelection of transduced CD34+ progenitors and enzymatic correction of cells from Gaucher patients, with bicistronic vectorsProgress in cancer gene therapy.Stem cell therapy and gene transfer for regeneration.Forced evolution of glutathione S-transferase to create a more efficient drug detoxication enzyme.Drug selection with paclitaxel restores expression of linked IL-2 receptor gamma -chain and multidrug resistance (MDR1) transgenes in canine bone marrow.In vivo enrichment of genetically manipulated platelets corrects the murine hemophilic phenotype and induces immune tolerance even using a low multiplicity of infectionBone marrow extracellular matrix molecules improve gene transfer into human hematopoietic cells via retroviral vectors.Topical colchicine selection of keratinocytes transduced with the multidrug resistance gene (MDR1) can sustain and enhance transgene expression in vivo.Oncogene-specific formation of chemoresistant murine hepatic cancer stem cells.Gene therapy: here to stay.Knockdown of HPRT for selection of genetically modified human hematopoietic progenitor cellsPreselective gene therapy for Fabry disease.Gene therapy to protect haematopoietic cells from cytotoxic cancer drugs.Molecular imaging of gene expression and protein function in vivo with PET and SPECT.Combined preconditioning and in vivo chemoselection with 6-thioguanine alone achieves highly efficient reconstitution of normal hematopoiesis with HPRT-deficient bone marrowProgress and limitations in cancer gene therapy.Drug-selected coexpression of human glucocerebrosidase and P-glycoprotein using a bicistronic vector.Ablation of Iqgap2 protects from diet-induced hepatic steatosis due to impaired fatty acid uptakeNovel retroviral vectors for efficient expression of the multidrug resistance (mdr-1) gene in early hematopoietic cells.Electroporation enhances c-myc antisense oligodeoxynucleotide efficacyRetroviral transduction of a mutant methylguanine DNA methyltransferase gene into human CD34 cells confers resistance to O6-benzylguanine plus 1,3-bis(2-chloroethyl)-1-nitrosourea.A proliferation switch for genetically modified cells.Genetic induction of immune tolerance to human clotting factor VIII in a mouse model for hemophilia ACotransduction with MGMT and Ubiquitous or Erythroid-Specific GFP Lentiviruses Allows Enrichment of Dual-Positive Hematopoietic Progenitor Cells In Vivo.Targeted expansion of genetically modified bone marrow cells.Hematopoietic stem cell gene therapy with drug resistance genes: an update.Gene therapy with drug resistance genes.Survival of the fittest: in vivo selection and stem cell gene therapyThe molecular basis of multidrug resistance in cancer: the early years of P-glycoprotein research.Improved engraftment of human hematopoietic cells in severe combined immunodeficient (SCID) mice carrying human cytokine transgenes.Interfering RNA-mediated purine analog resistance for in vitro and in vivo cell selection.Long-term polyclonal and multilineage engraftment of methylguanine methyltransferase P140K gene-modified dog hematopoietic cells in primary and secondary recipientsIn vivo selection of hematopoietic progenitor cells and temozolomide dose intensification in rhesus macaques through lentiviral transduction with a drug resistance gene.Improved retroviral gene transfer into murine and Rhesus peripheral blood or bone marrow repopulating cells primed in vivo with stem cell factor and granulocyte colony-stimulating factor.The level of mRNA encoding the amphotropic retrovirus receptor in mouse and human hematopoietic stem cells is low and correlates with the efficiency of retrovirus transduction.
P2860
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P2860
Selection of drug-resistant bone marrow cells in vivo after retroviral transfer of human MDR1.
description
1992 nî lūn-bûn
@nan
1992年の論文
@ja
1992年学术文章
@wuu
1992年学术文章
@zh
1992年学术文章
@zh-cn
1992年学术文章
@zh-hans
1992年学术文章
@zh-my
1992年学术文章
@zh-sg
1992年學術文章
@yue
1992年學術文章
@zh-hant
name
Selection of drug-resistant bo ...... oviral transfer of human MDR1.
@en
Selection of drug-resistant bo ...... oviral transfer of human MDR1.
@nl
type
label
Selection of drug-resistant bo ...... oviral transfer of human MDR1.
@en
Selection of drug-resistant bo ...... oviral transfer of human MDR1.
@nl
prefLabel
Selection of drug-resistant bo ...... oviral transfer of human MDR1.
@en
Selection of drug-resistant bo ...... oviral transfer of human MDR1.
@nl
P2093
P356
P1433
P1476
Selection of drug-resistant bo ...... oviral transfer of human MDR1.
@en
P2093
Gottesman M
Nienhuis AW
Sorrentino BP
P304
P356
10.1126/SCIENCE.1352414
P407
P577
1992-07-01T00:00:00Z